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UNIVERSITY OF JORDAN COLLEGE OF SCIENCE DEPARTMENT OF BIOLOGICAL SCIENCES COURSE OUTLINE Classification: Biology Compliant Catalogue: Course Code: Course title: Credit Hours: 0334231 Cell Biology 2 ( Theory ) Class Schedule: Laboratory Schedule: Tutorial Schedule: Duration : Sixty (60 ) minutes, Two sessions per week Course Coordinator: Prepared By: Date of Outline Preparation: Date of Last Revision: Cheched by: Approved by HoD: Prof. Dr. Ziad Shraideh Prof. Dr. Ziad Shraideh September 3, 2007 September 3, 2007 Sixteen (16 ) weeks 2 University of Jordan Faculty of science Dept. Biol. Sciences Course Outline I. Course Description 0334231 CELL BIOLOGY This course deals with the cell as a unit of structure of all living organisms. It includes: Cell theory. Principles and technology of microscopy, biological membranes: Ultrastructure and function and their role in controlling cellular responses to cell matrix. Intracellular compartments: Endoplasmic reticulum, golgi complex, lysosomes and pearoxiyoms ultrastructure and functioum. Energy transformers: Mitochondria and chloroplasts. The course concentrates also on the nuclear ultrastructure. Chromatin and DNA packaging. Nucleolus and ribosome’s biosynthesis. Cell cycle and mechanism of cell division. Also studies cellular junctions. Adhesions and extracellular structures. Cell-to-substratum interactions. Transient differentiations associated with surface activity. Motile cell processes. Plant cell wall and plasmodesmata and bacterial cell wall. The course investigates also the structural elements of cytoskeleton, microtubules, microfilaments and intermediate filaments ultrastructure and functions. Cellular movement: motility and contractility and cell-to cell signaling. The course deals also with cellular aspects of cancer, aging and death. II. Require Background or Experience Prerequisite by course: 0304102 General Biology 2 III. Course objectives ( Cell Biology 0334231 ) A. Knowledge and Understanding: Students will have an understanding of the biology of cells, especially eukaryotic cells . B. Cognetive / Intellectual Analysis: Students will be able to critically assess primary and applied research relating to The biology of cells. C. Subject-specific and practical skills: Students will be able to discuss topics relating to cell biology with others in a meaningful way. D. General transferable skills: Students will understand the principles underlying the application of several Laboratory techniques in cell biology research. IV.Textbook(s) and Readings: Textbook : Becker et al (2006). The World of the Cell. 6th Edition. Benjamin and Cummings Company, California. 3 Additional References: 1. Cell & Molecular Biology : Concepts & Experiments-3 rd Ed. By:Gerald Karp, John Wily & Sons, 2002. 2.Lodish et al (2000). Molecular Cell Biology. 4th ed. Scientific American Books. 3.Lodish et al (1995). Molecular Cell Biology. 3rd ed. Scientific American Books. 4.Karp (1999). Cell and Molecular Biology. 2nd ed. John and Wiley Sons. 5.Alberts et al (1991). Molecular Biology of the Cell. 2nd ed. Garland Publishing, New York. V. Student Materials: 1. Textbook and references 2. Lecture notes 3. CD and internet resources. VI. College Facilities: - Classroom with whiteboard and projection facilities - College library -Internet resourses VII. Course Outline: The following topics will be covered in this course: Lecture Number Topic page 1-2: Chapter 1: A Preview of the Cell 1-9 Cell Theory Emergence of Modern Cell Biology 3-5: Appendix : Principles & Techniques of Microscopy A1-A26 The light Microscopes Transmission Electron Microscopy Scanning Electron Microscopy 6-7: Chapter 7: Membranes:Their Structure , Function & Chemistry 154-186 Models of Membrane Structure Membrane Lipids : The Fluid Part of the Model Membrane Proteins: The Mosaic Part of the Model 8-9: Chapter 8: Transport Across Membranes: Overcoming the Permeability Parier 191Cells& Transport Processes 212 Simple Diffusion: Unassisted Movement Down the Gradient Facilitated Difusion: Protein-Mediated Movement Down the Gradient Active Transport: Protein-Mediated Movement Up the Gradient Examples of Active Transport 10 : Chapter 10: Chemotrophic Energy Metabolism: Aerobic Respiration 250-255 The mitochondrion: Where the Action Takes Place 11 : Chapter 11: Phototrophic Energy Metabolism: Photosynthesis 290-291 The Cloroplst: A Photosynthetic Organelle 12: First Hour Exam 13-18: Chapter 12: Intracellular Compartments: The Endoplasmic Reticulum, 318-358 Golgi Complex, Endosomes, Lesosomes, and Peroxisomes The Endoplasmic Reticulum. The golgi Complex. Roles of ER& Golgi Complex in Protein Glycosylation& Trafficking. 4 Exocytosis and Endocytosis: Transporting Material Across the Plasma Membrane. Coated vesicles in Cellular Transport Processes. Lysosomes and Cellular Digestion. The Plant Vacuole: A Multifunctional Organelle. Peroxisomes. 19-20: Chapter 14: Signal Transduction Mechanisms: Messengers and Receptors Chemical Signals and Cellular Receptors. G Protein-Linked Receptors Protei Kinase-Associated Receptors. Groth Factors as Messengers 392414 21-22: Chapter 15 : Cytoskeletal System 425-450 The Major Structural Elements of the Cytoskeleton Techniques for Studying the Cytoskeleton. Microtubules. Microfilaments Intermediate filaments 23-24: Chapter 16: Cellular Movement: Motility and Contractility 453-477 Motile Systems. Micdotubule-Based Motility Actin-Based Movement: The Myosins. Filament- Based Movement In Muscle. Actin-Based Motility in Nonmuscle Cells 25: Midterm Exam 26-27: Chapter 17:Beyond the Cell: Extacellular Structures, Cell Adhesion, 482-505 and Cell Junctions The Extracellular Matrix of Animal Cells. Cell-Cell Recognition Cell Junctions. The Plant Cell Surface 28-29: Chapter 18: The Structural Basis of Cellular Information: DNA, 533-550 Chromosomes, and the Nucleus DNA Packaging. The Nucleus 30 : Chapter 19 : The Cell Cycle, and Mitosis An Overwiew of the The Cell Cycle Regulation of the Cell Cycle VIII.Instructional Methods: 1. Lecture / Discussion sessions 2. Homeworks and Readings VIII. Evaluation of Outcomes: Evaluation will be based on the following: 1. First Hour Exam : 20% 2. Midterm Exam : 30% 5. Final Exam : 50% Major Exam Dates : First Hour Exam: At week # 6 Midterm Exam: At week # 12 Final Exam: At week # 16 IX. Lecturer: Prof. Dr. Ziad Shraideh Office: Room 311 (Biology Department ) Email: [email protected] Office Hours: Sun.,Tue. : 11-11:30 am. 554, 586-594 5