Download Rosalind Franklin

Name _______________________________________
Period _______
Date ______________
Rosalind Franklin
Secret of Photo 51
1. In 1962, a Nobel Prize is awarded to _______________________,
_______________________ and Maurice Wilkins for their groundbreaking
work on DNA.
2. In Watson’s book The Double Helix, he portrays
_________________________ as the character called Rosy that is said to
be bad tempered and a data hoarder.
3. Rosalind Franklin died at the age of ________.
4. Rosalind Franklin was born in _______________ in _______, into a family
that achieved wealth through banking and publishing.
5. Rosalind wins a scholarship to study physics and chemistry at
____________________ ____________________________.
6. The technique of __________ __________________________ can reveal
the hidden atomic structure of matter in its crystalline form.
7. Franklin joined the war effort doing research on __________.
8. Her experiments led to a better _______ _____________, a valuable
contribution to England under attack.
9. Her research was not without its risks so lab workers were periodically
checked for overexposure to ______________.
10. When trying to decide if she should stay in France or return home to
England, Rosalind asked the advice of _________________
________________, a renowned crystallographer and one of only ten
women to win a Nobel Prize.
11. Upon her return to England, Franklin is offered a position at __________
_______________ in London, a highly prestigious research center.
TWHS 2005
Name _______________________________________
Period _______
Date ______________
12. Avery's experiments with bacteria showed that genetic characteristics of
one organism could be transferred to another, and that _________ was the
vehicle of that transformation.
13. At the time, DNA was thought to consist of _______________ and
___________________ in long chains of some unknown shape, and it also
appeared to have just four other chemical ingredients, called
____________.
14. While Rosalind was setting up her new lab at King's College London,
___________ _______________—much younger, 23 but with a Ph.D.—
had come to Europe because he wanted to study the gene, and he was
convinced that the __________ was the thing to study.
15. Watson doesn’t find a job at King’s College but is invited to the
___________________, a famous research lab at Cambridge University,
headed by Nobel Laureate, Sir Lawrence Bragg.
16. There Watson is assigned an office with another physicist turned
crystallographer named ______________ _________________.
17. Franklin discovered that there were _______ forms of DNA.
18. The X shape in the middle of the B form of DNA is the diffraction
signature of a _________________.
19. Crick and Watson used a different approach to solving the structure of
DNA: _________________________________________.
20. Another scientist, ___________ _______________ had pioneered the same
model-building technique adopted by Watson and Crick, and with little
experimental data come up with the structure for long stretches of proteins,
a single-stranded helix.
21. The race to solve the structure of DNA is now on between the duo of
________________ & ______________ and ________________.
22. The number of lines in photo 51 shows that each twist of the helix has
______ units, or molecular building blocks.
TWHS 2005
Name _______________________________________
Period _______
Date ______________
23. From Franklin’s Medical Research Council report, Crick is able to deduce
from her symmetry pattern that there were ____ chains running in
_______________ directions.
24. William _____________ theorized that the four bases—adenine,
___________, guanine, and cytosine—would be stacked like pennies.
25. At Columbia University, Erwin Chargaff discovered that DNA always
contains equal amounts of adenine and thymine, as well as equal amounts
of _____________________ and __________________.
26. Watson discovers that he can fit the bases into the helix measured by
Franklin if he pairs A with ____ and G with _____. Arranged this way, the
bases form the connecting rungs in a twisting ladder on the inside of a
double helix.
27. In 1956, Rosalind Franklin celebrated her 36th birthday by climbing Mt.
Whitney, one of the highest peaks in North America. But near the end of
her trip, Franklin was suffering from severe ____________________
________.
28. On her return to England she was diagnosed with ___________. There is
speculation that her work with X-rays may have triggered the disease.
29. Franklin died on __________ ____, 1958 never knowing how much of
Watson & Crick’s discovery was based on her work.
30. In _________, James Watson, Francis Crick and _________________
_______________ won the Nobel Prize for their discovery of the structure
of DNA. Franklin's name receives no mention, save a passing reference by
Wilkins. Her crucial contribution to their work becomes a footnote in
scientific history.
31. What happens in the end of the movie?
“For Rosalind Franklin, the joy of science was in
the work itself and its ultimate reward, the betterment
of humankind.”
TWHS 2005