Download FAQs - Life Engineered Antibody Products

Life
Engineered
Antibody
Products, LLC
FAQs about the molecular analyzer and fabrication devices
Q1: What will the analyzer and fabricators do?
The analyzer will be able to determine the shape of both organic (mostly biologic) and
inorganic molecules down to the atomic, fraction of a nanometer, level. This is important
because molecules interact with each other based on their shape as well as electromagnetic
forces.
The biologic entity on which the concept is based is the antibody. Antibodies attach by
essentially a flexible shape-matching “lock and key “ mechanism to a target biological surface,
typically a bacteria, virus, or cancer cell. They are a major part of the disease fighting
mechanism. Currently, relatively small numbers of antibodies are being created in the lab by
cell culture, a biologic and laborious method. The analyzer will allow rapid, atomic level
determination of the shape of a target area. The fabricator will use that template to create a
molecular mate, and the desired number of multiples of that mate, to be able to attach to
targets wherever they occur. These synthetic antibodies are created entirely by rapid, physical
(atomic electromagnetic) methods, as detailed in the technical description of the inventions.
The desired functional “tag” can then be added (e.g. fluorescent marker, radiation source, or
toxin). Aberrant cells or viruses can be simply marked or also killed with currently used tags.
In the inorganic world, our analyzer-fabricator will be able to detect tiny amounts of any
toxin in liquid or gas, a possible Defense Department use.
Q2: What are the advantages of the analyzer-fabricator devices over existing types of
microscopes and scanners, DNA sequencers, and existing biologically created antibodies?
The first advantage is in surface resolution capability. One millimeter is a little bigger than
the dot on the “i” on this page. The resolution limit of X-rays, CT scans, mammograms, and
MRIs is about that. In decimal terms, a millimeter is 1/1000 of a meter. A micrometer is 1/1000
of a millimeter, and a nanometer is 1/1000 of a micrometer. A light microscope is limited to
about 1000 nanometer resolution. The scanning tunneling electron microscope, which yields
surface data, will get to about 10 nanometers. A pure transmission electron microscope which
does not give 3D surface structure, resolves at the same level as our analyzer. Our analyzer,
giving surface structure, will be able to resolve to atomic level, 0.2 nanometer, a 50 times
improvement over the scanning electron microscope. For comparison, a single wavelength of
visible light is about 500 nanometers.
The second advantage is in speed of analysis. Cell culture takes days to weeks. Even automated
DNA sequencing requires repetitive enzyme cleavage, mass spectrometry and chemical
detectors. Our analyzer will be able to take as many one million measures per second, to
determine the atomic composition of the molecule passing through its sensor hole. A
mathematical algorithm similar to those used in the MRI organizes the information with the aid
of a computer, and will present a visual shape image. The researcher can use this information
to look at various surfaces of the target molecule.
A third advantage is in limiting distortions of cell surfaces caused by drying and re-liquefying
cells and their components. Our analyzer will utilize standardized physiologic solutions.
A final advantage is in the sheer volume of information that can be gathered and evaluated.
Currently, some cancers have known differences in surface receptors or proteins produced
compared to normal cells. The variations take time to explore and then exploit. Our analyzer
would allow rapid comparison of multiple areas of cellular surface of normal and abnormal cells
within the same individual. It would also allow rapid characterization of multiple variations in
bacteria and viruses that could relate to resistance to antibiotics and antivirals.