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Pediatric Pharmacology Overview Elizabeth Allen NR, MSN Learning Objectives Nursing Considerations for Safe Preparation and Administration of Pediatric Medications Locate reconstitution and dilution instructions in mobile drug reference guide (Skyscape or drug book) Verify correct drug, appropriateness for clinical situation, lab values needing review and monitoring parameters Complete the necessary calculations to ensure safe dosage Pounds to kilograms, safe dosage range in milligrams per dose (may need to convert mg/kg/day to mg per dose) Reconstitute antibiotic medication according to manufacturers guidelines Dilute medication for administration according to manufacturers guidelines and as appropriate for the weight of the child Determine how the medication will be delivered and administer medication in the laboratory setting via IV push, piggy back or syringe pump (if syringe pump available) Assessing effectiveness of medication Pediatric Pharmacology Pediatric patients are not “little adults” Body surface area Absorption Immature organ systems Pediatric Pharmacology Medications given based on weight in kg Know exact weight for pediatric patient and each medication is calculated for dose Look up: Pediatric dosing May depend on condition Mg/kg/day in divided doses, maximum dose Adverse Effects Mechanism of Action Administration & Reconstitution Monitoring Pediatric Pharmacology Medication Order Medication Dose Route Time Parameters (ex. Severe pain, >7) Safety checks at: time of order, in pharmacy (verifying the order and preparing the medication) and by nurse prior to giving a medication Pediatric Pharmacology ATI Resources Med Math D(Desired dose) X V (Vehicle-tab or Liquid)=Amount to Give H (dose on hand) Example: Order-Dilantin 50mg p.o. TID Drug available-Dilantin 125 mg/5ml Pediatric Pharmacology Provider order: Look up pediatric dosage range Calculate dose to ensure it is safe Critically Think: Is this an appropriate drug given the clinical situation? Are there any assessments or labs to be done or checked prior to giving this dose? How can drug be administered (correct route?) How to reconstitute drug How quickly or slowly to give medication What potential side effects to assess for