Download : BIOGRAPHICAL SKETCH

Program Director/Principal Investigator (Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Thomas J. Belbin
eRA COMMONS USER NAME (credential, e.g., agency login)
Associate Professor
tbelbin
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Memorial University of Newfoundland, Canada
Memorial University of Newfoundland, Canada
B.Sc.
Ph.D.
1990
1999
Biochemistry
Molecular Biology
NOTE: The Biographical Sketch may not exceed four pages. Follow the formats and instructions on the
attached sample.
A. Personal Statement
I have a broad background in molecular biology and I am an Active Member of the Albert Einstein Cancer
Center (AECC) with expertise in all aspects of microarray technology. I will supervise all of the studies related
to the use of the Illumina methylation platform. I have previously completed a study of tumor classification in
head and neck squamous cell carcinoma that has been published in Cancer Research. I have also finished a
study of gene expression changes during tumor progression in head and neck tumors using cDNA arrays
containing 18,000 genes. That manuscript has been published in the Archives of Otolaryngology – Head and
Neck Surgery. Another recent publication describes the MSRE methylation microarray procedure for DNA
methylation profiling and its application to head and neck cancer DNA samples (Cytogenetics and Genome
Research (2006)). I have interacted extensively with our computational biologists working on new tools for
data analysis. My computer expertise has allowed me to create algorithms for rapid manipulation of data sets
and our relational databases. Overall, I have been a part of the tumor-profiling group and its collaborations
here at AECOM since its inception. I am also the PI on a parallel project to study prognostic CpG methylation
events in oropharyngeal cancer.
B. Positions and Honors
Positions and Employment
1999-2001
Postdoctoral Research Associate in Pathology, Albert Einstein College of Medicine.
2001-2002
Instructor in Pathology, Albert Einstein College of Medicine.
2002-2008
Assistant Professor, Department of Pathology, Albert Einstein College of Medicine
2008Associate Professor, Department of Pathology, Albert Einstein College of Medicine.
Honors
2003
2004
2nd Place, Outstanding Young Investigator at Albert Einstein College of Medicine
Winner, Henry L. Moses Prize for Research in Clinical Medicine
Other Experience and Memberships
2002Member, Albert Einstein College of Medicine Cancer Center
2003Member, American Association of Cancer Research (AACR)
2004Member, Advisory Committee for Albert Einstein College of Medicine Microarray Facility
2004Member, Albert Einstein College of Medicine Committee on Patents
2005Member, Senate of the Albert Einstein College of Medicine
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Program Director/Principal Investigator (Last, First, Middle):
C. Selected Peer-reviewed Publications
Belbin, T.J., Singh, B., Barber, I., Socci, N.D., Wenig, B., Smith, R., Prystowsky, M.B. and Childs, G. (2002).
Molecular classification of head and neck squamous cell carcinoma using cDNA microarrays. Cancer
Research 62: 1184-1190. PMID: 11861402.
Sanchez-Carbayo, M., Socci, N.D., Lozano, J.J., Li, W., Charytonowicz, E., Belbin, T.J., Prystowsky, M.B.,
Ortiz, A.R., Childs, G. and Cordon-Cardo, C. (2003). Gene discovery in bladder cancer progression using
cDNA microarrays. American Journal of Pathology 163: 505-516. PMID: 12875971.
Wreesman, V.B., Sieczka, E., Socci, N.D., Hezel, M., Belbin, T.J., Childs, G., Patel, S.G., Patel, K.N., Tallini,
G., Prystowsky, M.B., Shaha, A.R., Kraus, D., Shah, J.P., Rao, P.H., Ghossein, R. and Singh, B. (2004).
Genome-wide profiling of papillary thyroid cancer identifies MUC1 as an independent prognostic marker.
Cancer Research 64: 3780-3789. PMID: 15172984.
Belbin, T.J., Singh, B., Wreesmann, V., Socci, N.D., Sanchez-Carbayo, M., Masterson, J., Smith, R., Patel, S.,
Cordon-Cardo, C., Childs, G. and Prystowsky, M.B. (2005). Molecular profiling of tumor progression in head
and neck cancer. Archives of Otolaryngology – Head and Neck Surgery 131: 10-18. PMID: 15655179.
Adrien, L.R., Schlecht, N.F., Kawachi, N., Smith, R.V., Brandwein-Gensler, M., Massimi, A., Chen, S.,
Prystowsky, M.B., Childs, G. and Belbin, T.J. (2006). Classification of DNA methylation patterns in tumor cell
genomes using a CpG island microarray. Cytogenetics and Genome Research 114: 16-23. PMID: 16717445.
Basu, I., Cordovano, G., Das, I., Belbin, T.J., Guha, C. and Schramm, V.L. (2007). A transition state analogue
of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. Journal of Biological
Chemistry 282: 21477-21486. PMID: 17548352.
Belbin, T.J., Bergman, A., Brandwein-Gensler, M., Chen, Q., Childs, G., Garg, M., Haigentz, M., HogueAngeletti, R., Moadel, R., Negassa, A., Owen, R., Prystowsky, M.B., Schiff, B., Schlecht, N.F., Shifteh, K.,
Smith, R.V., Zheng, X. (2007). Head and neck cancer: reduce and integrate for optimal outcome.
Cytogenetics and Genome Research 118: 92-109. PMID: 18000360.
Schlecht, N.F., Burk, R.D., Adrien, L., Dunne, A., Kawachi, N., Sarta, C., Chen, Q., Brandwein-Gensler, M.,
Prystowsky, M.B., Childs, G., Smith, R.V. and Belbin, T.J. (2007). Gene expression profiles in HPV infected
head and neck cancer. Journal of Pathology 213: 283-293. PMID: 17893858.
Aleman, A., Adrien, L., Lopez-Serra, L., Cordon-Cardo, C., Esteller, M., Belbin, T.J. and Sanchez-Carbayo, M.
(2008). Identification of DNA hypermethylation of SOX9 in association with bladder cancer progression using
CpG microarrays. British Journal of Cancer 98(2): 466-473. PMID: 18087279.
Belbin, T.J., Schlecht, N.F., Smith, R.V., Adrien, L.R., Kawachi, N., Brandwein-Gensler, M., Bergman, A.,
Chen Q, Childs G, Prystowsky MB. Site-specific molecular signatures predict aggressive disease in HNSCC.
(2008). Head and Neck Pathology 2(4): 243-256.
Childs, G., Fazarri, M., Kung, G., Kawachi, N., Brandwein-Gensler, M., McLemore, M., Chen, Q., Burk, R.D.,
Smith, R.V., Prystowsky, M.B., Belbin, T.J. and Schlecht, N.F. (2009). Low level expression of microRNA’s
let7-d and miR-205 are prognostic markers of head and neck squamous cell carcinoma. American Journal of
Pathology 174(3): 736-745. PMID: 19179615.
Prystowsky, M.B., Adomako, A., Smith, R.V., Kawachi, N., McKimpson, W., Atadja, P., Chen, Q., Schlecht,
N.F., Parish, J.L., Childs, G. and Belbin, T.J. (2009). The histone deacetylase inhibitor LBH589 inhibits
expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma
cell lines. Journal of Pathology 218(4): 467-477. PMID: 19402126.
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Program Director/Principal Investigator (Last, First, Middle):
Ostrower, S.T., Fischer, T.C., Smith, R.V., Belbin, T.J., Bent, J.P. and Parikh, S.R. (2010). Gene expression in
the oropharynx of children exposed to secondhand smoke. Laryngoscope 120(12): 2467-2472. PMID:
21082746.
Basu, I., Locker, J., Cassera, M.B., Belbin, T.J., Merino, E.F., Dong, X., Hemeon, I., Evans, G.B., Guha, C.
and Schramm, V.L. (2011). Growth and metastases of human lung cancer are inhibited in mouse xenografts by
a transition state analogue of 5'-methylthioadenosine phosphorylase. Journal of Biological Chemistry 286(6):
4902-4911. PMID: 21135097.
Lleras, R.A., Adrien, L.R., Smith, R.V., Brown, B., Jivraj, N., Keller, C., Sarta, C., Schlecht, N.F., Harris, T.M.,
Childs, G., Prystowsky, M.B. and Belbin, T.J. (2011). Hypermethylation of a cluster of krüppel-type zinc finger
protein genes on chromosome 19q13 in oropharyngeal squamous cell carcinoma. American Journal of
Pathology 178(5): 1965-1874. PMID: 21514414.
D. Research Support
Ongoing:
NIH/NCI R33
CA103547-03
PI: Prystowsky
09/14/2004 – 08/31/2010
Proteomics analysis of head & neck squamous cell cancer
Role: Co-Investigator
The goal is to identify protein/peptide signals that will predict invasiveness or chemosensitivity of head and
neck squamous carcinoma.
ACS
RSG
CCE-114372
PI: Einstein
1/1/2008-12/31/2011
Epigenetic predictors of cancer in high-risk low grade cervical neoplasia
Role: Co-Investigator
A prospective evaluation of 100 CIN-1 patients to detect the epigenetic pattern that predicts progression, and
to see whether CIN-2/3 is associated with epigenetic patterns that were not present in the CIN-1 stage.
NIH/NCI R21
CA131648-01
PI: Belbin
7/15/2009-6/14/2011
Identification and Classification of Epigenetic Changes in Head and Neck Cancer
The goal of the proposed study is the global analysis of CpG island hypermethylation events in the DNA of
oropharyngeal squamous cell carcinoma (OPSCC), one subtype of HNSCC. These “epigenetic signatures” will
be used to identify CpG sequences frequently hypermethylated in cancer, and to characterize previously
indistinguishable molecular subtypes of OPSCC.
Completed:
NIH
R21
CA110342-01
PI: Haigentz
4/1/2005-3/31/2007
Depsipeptide for the treatment of head and neck cancer
Role: Co-investigator
A clinical trial of depsipeptide in patients with head and neck squamous cell carcinoma to assess the
anticancer activity of this drug by its novel mechanism of action of inducing re-expression of silenced genes.
The goal is to fully evaluate this novel therapy and to introduce the concept of transepithelial oral mucosa
brushings as a correlate of mucosal exposure in clinical trials for patients with this disease.
NIH
R21
CA104402-01
PI: Belbin
Array-based outcome prediction in head and neck cancer
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Program Director/Principal Investigator (Last, First, Middle):
The overall goal of our project is to use genomic technologies to identify patterns of gene expression in head
and neck squamous cell carcinoma that can be translated into new diagnostics to enhance clinical care and
identify potential new therapeutic targets to expand treatment options.
NIH
R03
CA115243
PI: Schlecht
4/1/2005-3/31/2007
Role: Co-investigator
HPV induced pathogenesis of head and neck cancer
This is an application to identify HPV-related gene expression events that predict clinical outcome and survival
in head and neck cancer (HNSCC) patients.
THANC Foundation
PI: Belbin
1/1/2008-12/31/2009
Molecular signatures predictive of high risk score in upper aerodigestive tract squamous cell carcinoma
(UADT-SCC)
The overall goal of this project is to apply supervised clustering analysis coupled with statistical modeling to
identify a panel of genes whose expression signature stratifies these tumors according to their histological “risk
assessment” categories (low, intermediate, and high-risk).
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