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Ciencia Ergo Sum ISSN: 1405-0269 [email protected] Universidad Autónoma del Estado de México México Díaz Hernández, Verónica; Merchant Larios, Horacio Bases moleculares de la determinación sexual en mamíferos Ciencia Ergo Sum, vol. 15, núm. 3, noviembre-febrero, 2008, pp. 287-296 Universidad Autónoma del Estado de México Toluca, México Available in: http://www.redalyc.org/articulo.oa?id=10415306 Abstract Our aim is to correlate classical concepts of sexual differentiation with current molecular mechanisms of sex determination in mammals. Josts paradigm established that sex determination depends upon endocrine activity of fetal testis. The establishment of a complex network of alternative molecular pathways of gene expression determines the formation of either ovaries or testis from undifferentiated gonads. Taking the mouse as a model system, we described the finding of several genes that are regulated following the expression of Sry in males and the alternate pathways found in females. We concluded that it remains to be known whether the data from the mouse model could be extended to other mammals, including humans. Keywords sex differentiation, sex determination, gonad, ovary, testis. How to cite Complete issue More information about this article Journal's homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative