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Redox Biocatalysis. Fundamentals and Applications
Description:
Paves the way for new industrial applications using redox biocatalysis
Increasingly, researchers rely on the use of enzymes to perform redox processes as they search for novel
industrial synthetic routes. In order to support and advance their investigations, this book provides a
comprehensive and current overview of the use of redox enzymes and enzyme–mediated oxidative
processes, with an emphasis on the role of redox enzymes in chemical transformations. The authors
examine the full range of topics in the field, from basic principles to new and emerging research and
applications. Moreover, they explore everything from laboratory–scale procedures to industrial
manufacturing.
Redox Biocatalysis begins with a discussion of the biochemical features of redox enzymes as well as
cofactors and cofactor regeneration methods. Next, the authors present a variety of topics and materials to
the research and development of full–scale industrial applications, including:
- Biocatalytic applications of redox enzymes such as dehydrogenases, oxygenases, oxidases, and
peroxidases
- Enzyme–mediated oxidative processes based on biocatalytic promiscuity
- All the steps from enzyme discovery to robust industrial processes, including directed evolution,
high–throughput screening, and medium engineering
- Case studies tracing the development of industrial applications using biocatalytic redox reactions
Each chapter ends with concluding remarks, underscoring the key scientific principles and processes.
Extensive references serve as a gateway to the growing body of research in the field.
Researchers in both academia and industry will find this book an indispensable reference for redox
biotransformations, guiding them from underlying core principles to new discoveries and emerging
industrial applications.
Contents:
PREFACE ix
1. Enzymes Involved in Redox Reactions: Natural Sources and Mechanistic Overview 1
1.1 Motivation: Green Chemistry and Biocatalysis 1
1.2 Sources of Biocatalysts 2
1.2.1 Plants and Animals as Sources of Redox Biocatalysts 3
1.2.2 Wild–Type Microorganisms 7
1.2.2.1 Yeasts 7
1.2.2.2 Fungi 8
1.2.2.3 Bacteria 8
1.2.3 Metagenomic Assessments 9
1.3 Overview of Redox Enzymes 10
1.3.1 Dehydrogenases 13
1.3.1.1 Zn–Dependent Dehydrogenases 14
1.3.1.2 Flavin–Dependent Dehydrogenases 15
1.3.1.3 Pterin–Dependent Dehydrogenases 16
1.3.1.4 Quinoprotein Dehydrogenases 17
1.3.1.5 Dehydrogenases without Prosthetic Group 18
1.3.2 Oxygenases 19
1.3.2.1 Monooxygenases 20
1.3.2.2 Dioxygenases 38
1.3.3 Oxidases 50
1.3.3.1 Iron–Containing Oxidases 50
1.3.3.2 Copper–Containing Oxidases 51
1.3.3.3 Flavin–Dependent Oxidases 56
1.3.4 Peroxidases 61
1.4 Concluding Remarks 64
References 64
2. Natural Cofactors and Their Regeneration Strategies 86
2.1 Types of Natural Cofactors Mechanisms 86
2.2 Cofactor Regeneration 88
2.2.1 Enzymatic Regeneration of Reduced Cofactors 88
2.2.1.1 Substrate–Assisted Method 88
2.2.1.2 Enzyme–Assisted Method 89
2.2.2 Enzymatic Regeneration of Oxidized Cofactors 92
2.2.3 Chemical Regeneration of Cofactors 94
2.2.4 Electrochemical Regeneration of Cofactors 95
2.2.5 Photochemical Regeneration of Cofactors 96
2.3 Concluding Remarks 97
References 98
3. Reactions Involving Dehydrogenases 101
3.1 General Considerations 101
3.2 Reduction of Carbonyl Groups 105
3.2.1 Reduction of Aliphatic and Aromatic Ketones 106
3.2.2 Reduction of – and –keto Esters and Derivatives 119
3.2.3 Reduction of Diketones 126
3.2.4 Reduction of Aldehydes 128
3.3 Racemization and Deracemization Reactions 130
3.4 Preparation of Amines 135
3.5 Reduction of C C Double Bonds 142
3.6 Oxidation Reactions 152
3.7 Dehydrogenase–Catalyzed Redox Reactions in Natural Products 159
3.8 Concluding Remarks 164
References 165
4. Reactions Involving Oxygenases 180
4.1 Monooxygenase–Catalyzed Reactions 180
4.1.1 Hydroxylation of Aliphatic Compounds 181
4.1.2 Hydroxylation of Aromatic Compounds 187
4.1.3 Baeyer Villiger Reactions 189
4.1.3.1 Classification and Metabolic Role of BVMOs 192
4.1.3.2 Isolated Enzymes versus Whole–Cell Systems (Wild–Type and Recombinant Microorganisms) 194
4.1.3.3 Substrate Profile of Available Baeyer Villiger Monooxygenases 195
4.1.3.4 Synthetic Applications of BVMOs 201
4.1.4 Epoxidation of Alkenes 240
4.2 Dioxygenase–Catalyzed Reactions 251
4.2.1 Aromatic Dioxygenases 251
4.2.1.1 Dihydroxylation of Aromatic Compounds 251
4.2.1.2 Other Oxidation Reactions Performed by Aromatic Dioxygenases 274
4.2.2 Miscellaneous Dioxygenases 279
4.2.2.1 Lipoxygenase 279
4.3 Concluding Remarks 285
References 286
5. Reactions Involving Oxidases and Peroxidases 303
5.1 Oxidase–Catalyzed Reactions 304
5.1.1 Oxidases Acting on C O Bonds 304
5.1.1.1 Galactose Oxidase 304
5.1.1.2 Pyranose Oxidase 308
5.1.1.3 Alcohol Oxidase 311
5.1.1.4 Glucose Oxidase 313
5.1.1.5 Glycolate Oxidase 313
5.1.2 Laccases and Tyrosinases (Phenol Oxidases) 315
5.1.2.1 Laccase 315
5.1.2.2 Tyrosinase and Other Polyphenol Oxidases 352
5.1.3 Oxidases Acting on C N Bonds 361
5.1.3.1 d–Amino Acid Oxidase 361
5.1.3.2 l–Amino Acid Oxidase 368
5.1.3.3 Monoamine Oxidase 368
5.1.3.4 Copper Amine Oxidases 371
5.1.4 Miscellaneous 371
5.1.4.1 Cholesterol Oxidase 372
5.1.4.2 Vanillyl Alcohol Oxidase 373
5.1.4.3 Alditol Oxidase 373
5.2 Peroxidase–Catalyzed Reactions 375
5.2.1 Peroxidase Mediated Transformations 379
5.2.1.1 Oxidative Dehydrogenation (2 RH + H2O2
5.2.1.2 Oxidative Halogenation (RH + H2O2 +X
5.2.1.3 Oxygen–Transfer Reactions (RH + H2O2
2R
+ 2 H2O R–R) 379
+ H+ RX + 2 H2O) 385
ROH + H2O) 390
5.3 Concluding Remarks 403
References 404
6. Hydrolase–Mediated Oxidations 433
6.1 Hydrolase Promiscuity and in situ Peracid Formation. Perhydrolases vs. Hydrolases. Other Promiscuous
Hydrolase–Mediated Oxidations 433
6.2 Hydrolase–Mediated Bulk Oxidations in Aqueous Media (e.g., Bleaching, Disinfection, etc.) 436
6.3 Lipase–Mediated Oxidations: Prileshajev Epoxidations and Baeyer Villiger Reactions 439
6.4 Hydrolase–Mediated Oxidation and Processing of Lignocellulosic Materials 445
6.5 Concluding Remarks 448
References 448
7. Bridging Gaps: From Enzyme Discovery to Bioprocesses 453
7.1 Context 453
7.2 Enzyme Directed Evolution and High–Throughput–Screening of Biocatalysts 454
7.3 Successful Case: Baker s Yeast Redox Enzymes, Their Cloning, and Separate Overexpression 467
7.4 Whole–Cells vs. Isolated Enzymes: Medium Engineering 473
7.5 Beyond: Multistep Domino Biocatalytic Processes 477
7.6 Concluding Remarks 482
References 483
8. Industrial Applications of Biocatalytic Redox Reactions: From Academic Curiosities to Robust Processes
487
8.1 Motivation: Drivers for Industrial Biocatalytic Processes 487
8.2 Key Aspects in Industrial Biocatalytic Processes 488
8.3 Industrial Biocatalytic Redox Processes: Free Enzymes 492
8.4 Industrial Biocatalytic Redox Processes Whole–Cells: The
(Metabolic Engineering) 500
Designer Bug
8.5 Concluding Remarks and Future Perspectives 511
References 516
INDEX 521
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