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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034 M.Sc. DEGREE EXAMINATION - BIOMED.INSTRUMENTATION SC. THIRD SEMESTER – November 2008 IB 06 BI 3806 - TECHNICAL PATHOLOGY Date : 05-11-08 Time : 9:00 - 12:00 Dept. No. Max. : 100 Marks SECTION-A Answer ALL the questions (10 x 2=20 Marks) 1. Comment on the importance of clearing agents. 2. What is Lentigo Maligna? 3. What is Tattooing? 4. Enumerate the factors that increase the risk of folliculities 5. What are the different staining methods? 6. Name a few proteins involved in amyloid process. 7. State the significance of icing? How is icing helpful” 8. What is a wear and tear pigment? 9. Differentiate atrophy from hypertrophy. 10. What is cytomegalo virus? SECTION –B Answer any FOUR the questions (4 x 10= 40 Marks) 11. Explain the molecular mechanism of apoptosis 12. How will you estimate the amount of amino acids present in a biological sample? 13. Can melanoma be treated? If so what types of treatment are used? And add note on the methods of treatment. 14. List down the different types of necrosis and explain it briefly 15. Describe the histochemical localization of carbohydrate by PAS Reaction. 16. Explain the sequence of events leading to irreversible cell injury. SECTION-C Answer any TWO the questions (2 x 20= 40 Marks) 17. Describe the metabolic steps and the pathological changes involved in steatosis 18. How will you diagnose eczema? And give the treatment, precaution and remedies for the treatment of eczema. 19. Which type of microtome is commonly used in histopathological techniques? Write the procedure involved in histopathological process in the laboratory. 20. Comment on: a) Scanning electron microscope b)Cryostat c) Flow cytometry d) Ultra microtome. ************** 1