Download Advanced Cardiovascular Stent Incorporated with a Nitric Oxide Delivery System Investigators:

Advanced Cardiovascular Stent Incorporated with a Nitric Oxide Delivery System
Investigators:
Hai-Lung Tsai ([email protected], 573-341-4945), Adam Hamdorf, Cheng-Hsiang Lin, Patrick
Margavio, Chi H Lee (UMKC), Richard Hopkins (UMKC), Yugyung Lee (UMKC)
Funding Source:
Missouri Life Science Research Board
Project Description:
Cardiovascular stents are metal scaffolds placed in a narrowed atherosclerotic artery to keep the
vessel open by providing structural support and prevent it from re-occluding, a condition called
restenosis in which endothelial cell growth proliferates around the device as part of the body’s
natural wound-healing response and impedes blood flow. Most bare metal stents are reported to
cause restenosis after a few months of surgery and thus newly developed stents are covered with
inhibitory agents to prevent restenosis. Even though the drug-releasing coatings for stents are an
exciting protective device that can provide an enormous clinical benefit, the drug coating may
peel and delaminate from the metallic surface of the stent due to poor adhesion between the
coating and the stent surface. The coating delamination can potentially lead to embolism, acute
thrombosis, inflammation and non-uniform delivery of drugs. In this proposal, we will attempt to
reduce restenosis and improve the biocompatibility of a metal scaffold (MS) with two
nanotechnology approaches: i) pattern modification by the nano/micromachining technique with
a femtosecond laser (FSL) and ii) the development of microparticles (MP) containing Nitric
Oxide (NO) using the double emulsion method. The key to this proposed study is the partnership
of interdisciplinary scientists in pharmaceutics, engineering, cardiology, advanced proteomics,
pharmacological and computer sciences, which seems to be an ideal approach for biomedical
research. This proposal is highly innovative in that we will develop the MS with different
patterns of the groove in its outer surface which can firmly retain NO loaded MP and exert a
controlled release rate of NO according to the loading conditions.
Publications:
•
C.H. Lin, Z. Rao, L. Jiang, W.J. Tsai, P.H. Wu, C.W. Chien, S.J. Chen, and H.L. Tsai,
“Investigations of Femtosecond–Nanosecond Dual–Beam Laser Ablation of
Dielectrics,” Optics Letters, vol. 35, pp. 2490–2492, 2010.
•
C.H. Lin, L. Jiang, Y.H. Chai, H. Xiao, S.J. Chen, and H.L. Tsai, “A Method to
Fabricate 2D Nanoparticle Arrays,” Applied Physics A, vol. 98, pp. 855–860, 2010.