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CHEMICAL ENGINEERING – Customized Delivery of Photodynamic Therapy to Tumor Sites Photodynamic therapy (PDT) is a disease treatment modality which uses optical radiation to generate highly reactive singlet oxygen atoms to kill malignant cells by exciting a photosensitizer drug applied to the lesions. To achieve a good PDT treatment outcome, a precise and effective optical delivery system with customizable optical output beam profile is important. In this project, we plan to use nanoparticles embedded in a photocurable polymer to create an optical scattering layer around the core of an optical fiber. This scattering layer allows optical radiation to emit to the side of the fiber through Rayleigh scattering. Since the output intensity is a function of the scattering cross-section, and the concentration of the nanoparticles embedded in the layer can be controlled during the application process, the goal is to provide an output beam profile that can be individually tailored based on the size and density of a patient’s tumor.