Download Introduction to Genetics (Dorn)

BIO 340/343 INTRODUCTION TO GENETICS
LECTURER: Dr. Lisa Dorn
Fall 2006
OFFICE: HS 45; PHONE: 424-3064; E-MAIL: [email protected]
OFFICE HRS: Mons & Fris, 10:20am to 12:20pm
LECTURE HOURS: 1:50 – 2:50 pm in Halsey Science Building; Rm. 260
TEXT: Brooker, Genetics: Analysis & Principles (2nd edition) McGraw Hill.
OBJECTIVES: Genetics and its experimental methods is one of the broadest and most
rapidly evolving fields of science. I cannot possibly cover it all, so my goal is to teach
you how to think like a geneticist, while learning genetics concepts so that you can judge
for yourself the value of emerging genetic technologies and discoveries. This course
covers Mendelian genetics and its complications, the molecular basis of genes and their
affect on phenotypes, the methods of identifying and characterizing the genetic basis of
diseases and other phenotypes as well as population and evolutionary genetics.
The prerequisites for this course are Bio105 and 323, which by extension means you have
taken Chem 105 and 106 as well as Bio111. Part of this course will expand on what you
have learned in Molecular and Cell Biology (Bio 323). I will assume you have mastered
the Bio323 material and will not waste much time reviewing this material. You will note
that one lecture is schedule to cover 4 Ch.s! Those 4 Ch.s contain the material that is
review of 323 with some embellishments not covered in 323. You may wish to review if
you feel your retention of the material in Bio 323 is weak.
ASSESSMENT: How are you going to earn your grade?
EXAMS: 4 exams each worth 100 points. They will be mostly problems similar
to those in the back of each Ch. (400 total points).
PROBLEM SOLVING: Worth 8 points each ( total = 96 points). There will
be 12 D2L problem-solving sessions where you will be required to solve problems that
will be available on D2L. These problems are presented as quizzes. The problems will
be available 1 week before they are due. During those days you are allowed to discuss
potential solutions with your peers and me but once you submit your answer you cannot
change it. You can only see the answers after you
LABORATORY: Is worth 100 points. The lab syllabus is available separately.
Total Possible points = 596.
92 – 100% = A, 89-91% = AB, 82-88% = B, 79-81% = BC, 72 – 78% = C, 68 – 71% =
CD, 67 – 60% = D, below 60 = F.
The schedule of lectures, exams and due dates for problems. There may be minor
changes to this schedule without notice. I will announce such changes in class.
Lecture
number
1
2
Day
Wed
Fri
Date
6-Sep
8-Sep
Mendels Laws; Monohybrid
Dihybrid Crosses & Pedigrees
Book
Ch. 2
Ch. 2
3
Mon
11-Sep
Pedigree Analysis; Probability Rules chi square Test
Ch. 2
2
4
Wed
13-Sep
Chromosomes; Meiosis & Mendel's rules
Ch. 3:
2
5
Fri
15-Sep
Sex chromosomes; Sex-Linked Traits
Ch. 3:
2
6
Mon
18-Sep
Sex determination; recessive Lethals
Ch. 3/4
3
7
Wed
20-Sep
Pleiotropy; Incomplete Dominance;
Ch. 4
3
8
Fri
22-Sep
co-dominance, gene dosage
Ch. 4
3
9
Mon
25-Sep
Overdominance, Penetrance, Expressivity
Ch. 4
4
10
Wed
27-Sep
Gene interactions, complementation
Ch. 4
4
11
Fri
29-Sep
Finish epistasis if necessary and/or review
Ch. 4
4
Mon
2-Oct
EXAM 1 (covers up to lecture 11)
2, 3 & 4
5
12
Wed
4-Oct
Linkage and Recombination;
Ch. 5
5
13
Fri
6-Oct
Mapping genes: dihybrid crosses
Ch. 5
5
14
Mon
9-Oct
Trihybrid crosses, Interference (no haploid ):
Ch. 5
6
15
Wed
11-Oct
Ch. 6
6
16
Fri
13-Oct
Complementation tests and deletion mapping
Ch. 6
6
17
Mon
16-Oct
Complementation tests and deletion mapping;
Ch. 6
7
18
Wed
18-Oct
DNA review: Ch.s 9, 10 and 11, 13 (genetic code)
19
Fri
20-Oct
Gene Transcription
20
Mon
23-Oct
Gene Transcription
Wed
25-Oct
'EXAM 2 (covering lectures 11 to 20)
21
Fri
27-Oct
Post-Transcriptional Processing
Ch. 12
8
22
Mon
30-Oct
Post-Transcriptional Processing
Ch. 12
9
23
Wed
1-Nov
Transcriptional Regulation in Eukaryotes
Ch. 15
9
24
Fri
3-Nov
Transcriptional Regulation in Eukaryotes
Ch. 15
9
25
Mon
6-Nov
Transcriptional Regulation in Eukaryotes
Ch. 15
10
26
Wed
8-Nov
Chromosomes: Change in Number ;
Ch. 8
10
27
Fri
10-Nov
Chromosomes: Structure; Nat'l Variation & Mutations Problems due
Ch. 8
10
28
Mon
13-Nov
Chromosomes
Ch. 8
11
29
Wed
15-Nov
Gene Mutation and DNA repair
Ch. 16
11
30
Fri
17-Nov
Gene Mutation and DNA repair
Ch. 16
11
Mon
20-Nov
'EXAM 3 ( Lectures 21 to 30)
12
Tues
21-Nov
Thanksgiving Recess
12
Wed
22-Nov
Thanksgiving Recess
12
Topics
Problems due
Problems due
Problems due
Problems due
Intragenic Mapping, bacteriophage
Problems due
Week
1
1
7
Problems due
Ch. 12
7
Ch. 12
8
8
Problems due
Problems due
Fri
24-Nov
Thanksgiving Recess
12
31
Mon
27-Nov
Non-Mendelian Inheritance: Epigenetics
Ch. 7
13
32
Wed
29-Nov
Non-Mendelian Inheritance: maternal effects
Ch. 7
13
33
Fri
1-Dec
Quantitative Genetics
ch 24
13
34
Mon
4-Dec
Quantitative Genetics
Ch 24
14
35
Wed
6-Dec
Quantitative Genetics
Ch 24
14
36
Fri
8-Dec
Population Genetics
Ch 25
14
37
Mon
11-Dec
Population Genetics
Ch 25
15
38
Wed
13-Dec
Population Genetics
Ch 25
15
39
Fri
15-Dec
EXAM 4
Problems due
Problems due
Problems due
Students With Disabilities are welcome in this class! If you need special
accommodations please contact me during office hours in the first week of class. This
includes students with diagnosed learning disabilities. If you feel you should be
evaluated for a learning disability please contact the Project Success office at 920 4241033 or go to their website at http://www.uwosh.edu/organizations/success.
Classroom Etiquette: please silence all pagers and cell phones; do not talk or whisper
unless called upon in turn (but feel free to raise your hand for a question or comment at
ANY time!).
Incomplete Grades may be given in extreme circumstances, such as when a student
becomes too ill to complete the semester's work. Please talk to me if you think your
situation warrants an "I" grade and be prepared to provide documentation.
Late Assignment Submissions may be penalized up to one grade point (e.g. from a B to
a C) at the Instructor's discretion.
Make up exams. If you cannot make one exam several alternatives may be available to
you depending on the rest of my teaching obligations at that time. I will do what I can,
given your circumstance. If you know ahead of time that you must miss an exam (for
instance if your job requires that you work that day) please let me know ahead of time.
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