Download Thilo HAGEN

Thilo HAGEN
M.D. (Berlin)
Associate Professor,
Yong Loo Lin School of Medicine
Department of Biochemistry
MD6-14,
Phone: 6516 3686
E-mail : [email protected]
MAJOR RESEARCH INTERESTS
Our laboratory is currently interested in a number of aspects related to cancer
biology and human metabolism. These include understanding basic
mechanisms that underlie cellular signaling and energy metabolism. Another
emphasis in our lab is to identify new therapeutic strategies targeting the
cellular stress response. Finally, we are trying to develop novel agents and
tools for drug discovery for the treatment of obesity and cancer.
Current projects include:
1. Deregulation of cellular metabolism in cancer
2. The cellular response to stress signals
3. Development of novel therapeutic strategies and tools for drug discovery
for the treatment of obesity and cancer
4. Isolation of endophytes from non-flowering, tropical plants and use in
different bioassays
RECENT PUBLICATIONS
1. CY Tan, T Hagen. Post-translational regulation of mTOR complex 1 in
hypoxia and reoxygenation. Cell Signal 25:1235-44 (2013).
2. RW Wong, T Hagen. Mechanistic target of rapamycin (mTOR) dependent
regulation of thioredoxin interacting protein (TXNIP) transcription in
hypoxia. Biochem Biophys Res Commun 433:40-6 (2013).
3. CY Tan, T Hagen. Destabilization of CDC6 upon DNA damage is
dependent on neddylation but independent of Cullin E3 ligases. Int J
Biochem Cell Biol. 45:1489-1498 (2013).
4. SY Hong, T Hagen. Multiple myeloma Leu167Ile (c.499C>A) mutation
prevents XBP1 mRNA splicing. Br J Haematol 161:898-901 (2013).
5. CY Tan, T Hagen. mTORC1 Dependent Regulation of REDD1 Protein
Stability. PLoS One 8:e63970 (2013).
6. L Cordero-Espinoza, T Hagen. Regulation of Cullin-RING Ubiquitin Ligase
1 by Spliceosome-associated protein 130 (SAP130). Biol Open In
press (2013).