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Copyright © 2004, Mosby Inc. All rights reserved. Chapter 21 Poisoning and Overdoses Slide 1 Copyright © 2004, Mosby Inc. All rights reserved. Case History You are dispatched to a poisoning and find a 5-year-old girl who is suspected of having ingested a large quantity of acetaminophen (Tylenol) tablets. The mother shows you an empty bottle, but the child appears perfectly normal and has normal vital signs. The child is alert and oriented. Slide 2 Copyright © 2004, Mosby Inc. All rights reserved. Introduction • Poison A substance that usually kills, injures, or impairs an organism through its chemical action • Overdose Drugs, taken in excess or in combination with other agents, to the point where poisoning occurs Slide 3 Copyright © 2004, Mosby Inc. All rights reserved. Incidence • More than 5 million poisonings occur each year in U.S. Most occur in children <5 years of age. • Poisonings cause more than 10,000 deaths. • Other causes Drug abuse Suicide Animal or insect bites Slide 4 Copyright © 2004, Mosby Inc. All rights reserved. Poison Control Centers • Provide access to experts in toxicology. • Staffed 24 hours a day. • Coordinate emergency response Provide advice to patients at home Refer people to area hospitals with poisoning care capabilities Advise EMTs, physicians, and nurses Slide 5 Copyright © 2004, Mosby Inc. All rights reserved. Types of Poisonings • Ingested • Injected • Inhaled • Absorbed Slide 6 Copyright © 2004, Mosby Inc. All rights reserved. Cardinal Rules • Treat the patient, not poison. • Protect self and bystanders. • Look for clues of trauma. • Maintain a high level of suspicion. Slide 7 Copyright © 2004, Mosby Inc. All rights reserved. Scene Size-up • Survey the scene to protect yourself and bystanders. • Dangers Toxic gases Absorbed toxins • Do not enter without adequate protection. Only trained hazmat rescuers should enter. Slide 8 Copyright © 2004, Mosby Inc. All rights reserved. Initial Assessment • What is your general impression? • Findings indicate any trauma? • Is the patient awake and responsive? • Airway, Breathing, Circulation Slide 9 Copyright © 2004, Mosby Inc. All rights reserved. Focused History • What is the poison? • How was it taken? Was it ingested, inhaled, absorbed, or injected? • When was it taken? • How much was taken? • Over what period of time? Slide 10 Copyright © 2004, Mosby Inc. All rights reserved. Focused History • Is there any other evidence at the scene (e.g., commercial products, pills)? • Were any other interventions attempted? Vomiting Dilution Activated charcoal Syrup of ipecac Antidote • How much does the patient weigh? Slide 11 Copyright © 2004, Mosby Inc. All rights reserved. Perform a Focused Physical Examination • • • Skin Pupils Breath sounds • • • Abdomen Mental status Vital signs Slide 12 Copyright © 2004, Mosby Inc. All rights reserved. Emergency Medical Care • Remove patient from poisonous environment. • Ensure patent airway and administer oxygen. • Be alert for vomiting. • Bring all poison agents to hospital. Containers Bottles Labels Slide 13 Copyright © 2004, Mosby Inc. All rights reserved. Ingested Poisons – Signs and Symptoms • • • • History of ingestion Nausea Vomiting Diarrhea Slide 14 Copyright © 2004, Mosby Inc. All rights reserved. Ingested Poisons – Signs and Symptoms • Altered mental status • Abdominal pain • Chemical burns around the mouth • Different breath odors Slide 15 Copyright © 2004, Mosby Inc. All rights reserved. Odors Smell Possible Poison Acetone (sweet, fruity) Ethanol, isopropyl alcohol, diabetic Alcohol Alcohol, isopropyl alcohol Disinfectants Creosol and phenol Rotten eggs Hydrogen sulfide Garlic Insecticides Stale tobacco Nicotine Wintergreen Methyl salicylate Slide 16 Copyright © 2004, Mosby Inc. All rights reserved. Emergency Medical Care • Remove poison from patient’s mouth using gloves. • Consult medical direction. Activated charcoal • Bring all containers (bottles, labels, etc.,) to hospital. Slide 17 Copyright © 2004, Mosby Inc. All rights reserved. Types of Ingestions • Sedative-hypnotics • Antianxiety agents • Opioids • Psychiatric medications • Stimulants Slide 18 Copyright © 2004, Mosby Inc. All rights reserved. Types of Ingestions – Sedative-Hypnotics • Barbiturates Secobarbital (Seconal) Pentobarbital (Nembutal) • Benzodiazepines Diazepam (Valium) Chlordiazepoxide (Librium) Chlorazepate (Tranxene) Slide 19 Copyright © 2004, Mosby Inc. All rights reserved. Types of Ingestions – Sedative-Hypnotics • Others Methaqualone (Quaalude) Ethchlorvynol (Placidyl) Chloral hydrate (Noctec) Mebrobamate (Miltown) Slide 20 Copyright © 2004, Mosby Inc. All rights reserved. Toxic Effects – Sedative-Hypnotics • Altered mental status • Respiratory depression and arrest • Most toxic when combined with alcohol • Support of ABCs is critical. Slide 21 Copyright © 2004, Mosby Inc. All rights reserved. Types of Ingestions Opioids (Narcotics) • Central nervous system depressant Examples » Heroin » Morphine » Percocet » Percodan Slide 22 Copyright © 2004, Mosby Inc. All rights reserved. Toxic Effects/Management – Opioids (Narcotics) • Toxic effects and signs and symptoms • Altered (depressed) mental status Respiratory depression Pinpoint pupils Track marks Management Support ABCs Administration of naloxone (Narcan) by ALS providers or hospital Slide 23 Copyright © 2004, Mosby Inc. All rights reserved. Ingested Substances • Stimulants Cause increased excitability (e.g., amphetamines) • Alcohol • Heart and lung drugs • Analgesics Slide 24 Copyright © 2004, Mosby Inc. All rights reserved. Inhaled Poisons – Signs and Symptoms • History of inhalation of toxic substance • Dizziness • Headache • Confusion • Difficulty breathing • Chest pain • Cough • Seizures • Hoarseness • Altered mental status Slide 25 Copyright © 2004, Mosby Inc. All rights reserved. Poisonous Gases • Simple asphyxiants • Carbon dioxide • Small hydrocarbon molecules • Chemical asphyxiants • Irritant gases • Organophosphates Slide 26 Copyright © 2004, Mosby Inc. All rights reserved. Toxic Injection – Signs and Symptoms • Weakness • Dizziness • Chills • Fever • Nausea • Vomiting Slide 27 Copyright © 2004, Mosby Inc. All rights reserved. Absorbed Poisons – Signs and Symptoms • History of exposure • Liquid or powder on patient’s skin • Burns • Itching • Irritation • Redness Slide 28 Copyright © 2004, Mosby Inc. All rights reserved. Emergency Medical Care • Skin Remove contaminated clothing. Protect self from contamination. • Powder Brush powder off patient. Irrigate for at least 20 minutes. Continue en route to facility, if possible . • Liquid Irrigate for at least 20 minutes. Continue en route to facility, if possible. Slide 29 Copyright © 2004, Mosby Inc. All rights reserved. Medication Name • Generic Activated charcoal • Trade SuperChar™ InstaChar™ Actidose™ LiquiChar™ Slide 30 Copyright © 2004, Mosby Inc. All rights reserved. Activated Charcoal • Indications Poisoning by mouth • Contraindications Altered mental status Ingestion of acids or alkalis Inability to swallow Slide 31 Copyright © 2004, Mosby Inc. All rights reserved. Medication Form • Medication is pre-mixed in water. Plastic bottle containing 125 grams activated charcoal • Powder should be avoided in field. Slide 32 Copyright © 2004, Mosby Inc. All rights reserved. Dosage • Adults and children 1 gram activated charcoal/kg of body weight • Usual adult dose 25 - 50 grams • Usual infant/child dose 12.5 - 25 grams Slide 33 Copyright © 2004, Mosby Inc. All rights reserved. Actions • Charcoal binds to certain poisons. • Binding action prevents absorption. • Not all brands are the same. Some bind much more poison Consult medical direction about the brand to use. Slide 34 Copyright © 2004, Mosby Inc. All rights reserved. Side Effects • Black stool • Some patients may vomit. If the patient vomits, repeat dose one time. • Reassessment strategies Prepare for vomiting and deterioration of patient’s condition. Slide 35 Copyright © 2004, Mosby Inc. All rights reserved.