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Phases of Healing The Inflammatory Response • Always the same regardless of location and nature of injury – Physiologic changes – Anatomic Changes • Process begins immediately after the injury occurs • Lasts for 2 - 4 days • Initial inflammatory response is critical to the entire healing process The Inflammatory Response • Cellular injury results – altered metabolism – release of materials that initiate the inflammatory response • Acute Inflammation • Characteristics – Chemical changes – Redness – Metabolic changes – Swelling – Vascular changes – Tenderness and pain – Increased temperature – Loss of function The Inflammatory Response • Normal healing can’t take place if inflammatory response – does not accomplish what it is supposed to – does not subside • Use of anti inflammatory medications (NSAIDS) immediately after injury may prevent the inflammatory process from taking place thus delaying the healing process • In most athletic injuries • Torn vessels allow hemorrhage into the immediate area • Cells sustain structural damage • Enzymes from damaged cells cause inflammatory response • Cell death occurs • Cells degenerate releasing substances (histamines) • Histamines cause vascular changes in non disrupted vessels – Increased permeability of capillaries – Cells in the vessel wall pull away from each other leaving gaps – Fluid and blood escape through these gaps into spaces between cells • Edema or swelling result Vascular Reaction • Lasts 5 to 10 minutes – Decreased blood flow followed by – Transitory increase of blood flow – Followed by slowing of flow by stagnation • Initial effusion lasts 24 - 36 hours Post Injury Vascular Events • White blood cells – tumble along and then adhere to vessel wall – escape through the vessel wall into the tissue spaces – outside the vessel they migrate to the injury site – phagocytosis (process of ingesting or removing irritating materials) • Cellular debris • Red blood cells • Anything else that is in the way of healing Clot Formation • Blood platelets adhere to collagen fibers in vessel wall creating a sticky matrix • Additional blood products adhere forming a plug or clot • Plug obstructs further fluid loss • Begins approximately 12 hours after injury • Completed within 48 hours Rehabilitation during the Inflammatory Response • Prevent additional injury to the tissues • Control inflammation • The amount of exudate* is directly related to the total healing time • RICE and modalities – Healing can begin – Total healing time will be decreased *material passed through the walls of vessel into adjacent spaces or tissues during inflammation Chronic Inflammation • By product of enzyme release into surrounding inflammatory fluid • These enzymes attack joint tissues • Inflammatory response to disease in a joint cavity may be natures way of removing toxic or foreign materials like bacteria • In athletic injuries there is no bacteria • Prolonged continuation of this response may also cause damage to surrounding joint structures • Persistent inflammatory response – Can lead to irreversible tissue damage – Fibrosis can occur in synovial structures Phase 2: The Fibroblastic Repair Process • Begins within first few hours after injury • The period of scar formation is called fibroplasia • May last 4 - 6 weeks • Inflammatory debris has been destroyed or removed • Clean-up and repair occur simultaneously • Enough debris must be removed to permit in growth of new tissue Phase 2 The Repair Process • Proliferative and regenerative activity lead to – Scar formation – Repair of injured tissue • Growth of capillaries into the wound is stimulated by lack of oxygen • Promotes increased healing by increasing oxygen delivery • Essential for tissue regeneration • Formation of granulation tissue occurs (a delicate connective tissue) Phase 2 The Repair Process • Scar tissue formation progresses – Production of collagen fibers – Deposited in random fashion – Form a scar – Scar tissue formation is minimal in this phase – Day 6 or 7 • Collagen continues to proliferate • Tensile strength of wound increases proportional to rate of collagen synthesis Phase 2 The Repair Process • Signs and symptoms of inflammation begin to subside – Patient may still have • Tenderness • Pain with motions that stress the injured structure – Complaints of tenderness and pain disappear over time Rehabilitation during Phase 2 The Repair Process • Begins the process of repairing damaged tissues • Under controlled conditions – Restore Range of Motion – Increase Strength Rehabilitation during Phase 3 • Involves returning the athlete to activity – Sport – Work – ADL’s • Patient learns how to use injured body part to maximum potential • Prevention of reinjury