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Download Let`s move to the Adrenal Glands
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Let’s move to the Adrenal Glands In this space, please draw an adrenal gland…. Where does it live, what is its shape? Does it communicate with the kidney? Did you include the inner and outer part of the adrenal gland? What are the 2 parts of the Adrenal Gland??? Inner part is the _________ ________ What does the inner part secrete or release? _____________________ ______________________ What are the 2 parts of the Adrenal Gland??? Outer part is the _________ ________ What does the outer part secrete or release? _____________________ _____________________ ______________________ Sugar….Salt….and Sex Let’s go with the Adrenal Cortex first….. 3 Hormone types: Glucocorticoids (Cortisol) Mineralocorticoids (Aldosterone) Androgens (Testosterone) Or………..Sugar, Salt and Sex Disorder #1 Cushing’s Disease We are nurses taking care of a patient with Cushing’s Syndrome What is Cushing’s syndrome? Too much _______________ What is a synthetic form of cortisol that you have probably administered in clinical to your patients? Syndrome vs Disease……….. Too much Cortisol…. What do you remember about cortisol or side effects of glucocorticoids? Write down here what you remember….. Cushing’s Syndrome vs Cushing’s Disease Syndrome is iatrogenically induced, how? ________________________ Cushing’s disease could be caused by a tumor causing too much cortisol release. Where could the tumor be located? 1. ________________ 2._____________ 3. ___________________ Textbook Pic of Cushing’s Syndrome/Disease Can we live without glucocorticoids or cortisol? What does cortisol do in our body? CHO (carbohydrate) metabolism Fatty acid mobilization Protein catabolism Ding ding Function of Cortisol or Glucocorticoids: ***CHO Metabolism What happens when we break down carbohydrates? Increase in amount of glucose formed Increase in amount of glucose released Therefore a major complication is _______________________ Function of Cortisol: *****Fat metabolism What happens when we mobilize fatty acids somewhere unusual? Therefore we see some classic body image changes in our patient-name these here: ________________ ________________ ________________ Re Group for a POC Activity Develop a plan of care for a patient with Cushing’s Disease What are the priorities? What can the nurse expect to see in this patient? Function of Cortisol: ****Protein breakdown or catabolism What happens in Cushing’s syndrome with protein breakdown, how does this look in our patients? ____________________________ ____________________________ Re Group for a POC Activity Develop a plan of care for a patient with Cushing’s Disease What kind of things can the nurse call the physician about in preventing complications in this patient? SBAR ideas? Clinical reasoning…. If glucocorticoids have a mineralocorticoid like effect, what would we see in our patients? Too much Aldosterone or Hyperaldosteronism Excessive retention of Na and H2O Excessive excreting of K+ So what would we see in clinical in our patients? _______________________ _______________________ Still in the Adrenal Cortex…now 2nd major group of hormones Mineralocorticoids or Aldosterone You know this…what does aldosterone do? What stimulates its’ release? Still in the Adrenal Cortex…now 3rd major group of hormones Androgens or Testosterone What happens if females have too much testosterone? _____________ _____________ _____________ What diagnostic tests could help diagnose Cushing’s Disease? Serum cortisol levels Serum ACTH levels CT scan of abdomen or adrenals MRI of brain to detect if pituitary adenoma 24 hour urine for cortisol Normal Cortisol Levels What would we expect to see in Cushing’s, what would the graph look like? Try to draw here So in summary, what effects the release of cortisol? ________________________ What would the serum levels of cortisol be at 8am vs 8pm? ________________________ Collaborative Management of Cushing’s Disease Need to know what first????? _____________________________ Open adrenalectomy or laparoscopic adrenalectomy if tumor or cancer of adrenal gland What if it is an ectopic tumor releasing too much ACTH? How would this be managed or treated? __________________________ What other surgery could be necessary? ______________________________________ Medications-Cushing’s Disease Mitotane (Lysodren) which suppresses cortisol production if surgery not an option Ketoconazole (Nizoral) inhibits cortisol synthesis Activity: Look up doses and routes of these medications and list as would be on the MAR Medications-Cushing’s Disease Mitotane (Lysodren) Ketoconazole (Nizoral) Why would these be called a “medical adrenalectomy” Write a detail nurse’s note on the appearance of the client’s skin or “Prednisone skin” Prednisone skin documentation Skin is fragile, thin and has decreased elasticity. Multiple areas on all 4 extremities of dark purple bruises. What assessment findings would you document? Cushing’s Disease-During Cushing’s Disease-After Treatment Now the innermost part of Adrenal Gland What is it called? _________________________ What does it release? 1.___________________ 2.___________________ What “response” does it trigger? ____________________________ Ok let’s summarize, how to collaboratively intervene in patient with Cushing’s disease/syndrome? Disorder #2 Hyperaldosteronism Too much aldosterone secretion What does aldosterone do? _________________ _________________ _________________ Usually caused by a tumor on Adrenal cortex Clinical Manifestations: Hyperaldosteronism Headache due to Na and H2O retention HTN due to Na and H2O retention K+ excretion which leads to ________ muscle weakness, fatigue cardiac dysrhythmias usually no edema Diagnostic Tests: Hyperaldosteronism urinary K+ plasma aldosterone levels with low plasma renin levels---WHY? CT scan will reveal adenoma of adrenal gland EKG changes Collaborative Management of Hyperaldosteronism Low sodium diet K+ sparing diuretic such as aldactone… How will this help perfectly??? ___________________________ Calcium channel blockers to treat the elevated blood pressure Adrenalectomy Disorder #3 Addison’s Disease Which famous President had Addison’s Disease? What is Addison’s Disease Too little of Sugar, Salt, and Sex glucocorticoids mineralocorticoids androgens Not enough Cortisol? POC priorities ________________________ ________________________ ________________________ ________________________ Not enough Aldosterone…..POC priorities ______________________ ______________________ ______________________ Salt craving—why? Not enough Androgens…what could be a priority? ______________________ Diagnostic Studies-Addison’s Disease Serum cortisol levels or Urine cortisol high or low Hypo or hyper kalemic? Serum glucose levels or Serum aldosterone levels high or low? EKG peaked T waves due to hyperkalemia In summary… Low bp F & E imbalances Hypoglycemic Hyponatremia Hyperkalemia Nausea and Vomiting Dehydration Anxiety, irritable Addisonian Crisis or Acute Adrenal Crisis Severe hypotension Tachycardia Severe nausea and vomiting Hypovolemic shock Hypoglycemia Hyponatremia Hyperkalemia Emergency TreatmentAddisonian Crisis or Adrenal Crisis Rapid infusion of IV fluids (D5NS) Frequent VS and I & O May need to administer vasopressors to bring up blood pressure Solucortef IVP until enough glucocorticoid on board Collaborative Management Addison’s Disease Oral glucocorticoids 2/3 dose in am 1/3 dose in pm DOC is Cortate po Oral mineralocorticoid Florinef 0.1mg po Lifelong hormone replacement Stress management Patient Teaching-Addison’s –ding ding Salt additives for excess heat or humidity Daily glucocorticoid replacement Daily mineralocorticoid replacement List of all meds Medical identification device in wallet, or in the form of a bracelet or necklace Conditions requiring larger dose of hormones (surgery, trauma, happy stress) IM glucocorticoid administration by patient (100mg hydrocortisone kit) Disorder #4 Pheochromocytoma-in the Adrenal Medulla Rare, benign tumor of the adrenal medulla Oh no, what are we going to see a hyper secretion of??? ___________________ ___________________ Clinical Manifestations Hallmark is hypertension-200/150 or > NE and Epinepherine released sporadically Deep breathing Profound sweating due to peripheral vasoconstriction Pounding HR Headache Visual disturbances “Spells” or paroxysmal attacks ◦ Triggers can be from bladder distension, exposure to cold, emotional distress PheochromocytomaDiagnostic Studies Increase serum NE and Epinepherine levels Increase in urine metabolites of NE and Epinepherine CT scan of adrenal gland(s) MRI of adrenal gland(s) Collaborative ManagementPheochromocytoma Adrenergic Blocker 1. Minipress to decrease bp Beta blocker 1. Inderal to decrease HR and bp and force of contraction also helps reduce anxiety Monitor vs Adrenalectomy-usually laporoscopic If having episode, elevate HOB and complete bedrest During surgery….and post op Potent vasodilator Regitine or Nipride administered due to manipulation of tumor in the medulla and surge of NE and Epi BP may be elevated initially, but can bottom out post operatively, why? If not a surgical candidate, then drug Demser (drug which inhibits catecholamine synthesis) is given Actual Case at UMCB: 25 yo male from Bastrop Hx of Insulin dependent DM and hypothyroidism Admitted via ED and transferred to IMC then to tele unit On admission: Na=118 K+=8.4 TSH=46.1 Low testosterone levels 16 lb weight loss past 6 weeks What should be included in POC? What other data do you need? What are this patient’s priorities?
