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Respiratory System Respiratory System  Main functions:     Provide oxygen to cells Eliminate carbon dioxide Works closely with cardiovascular system to accomplish gas exchange Gas exchange occurs in lungs Upper Respiratory Passageways    Air enters through nose, past sinus cavities Air then passes through pharynx Pharynx divided into three regions:    Nasopharynx (upper) Oropharynx (middle) Laryngeal (lower) Lower Respiratory Passageways and Lungs     Pharynx conducts air into trachea, through larynx and glottis Epiglottis prevents food from entering respiratory tract Larynx contains vocal cords (allows speech) Trachea divides into bronchus   Smallest tubes = bronchioles Alveoli = microscopic air sacs where gas exchange occurs Breathing  Ventilation made up of:  Inspiration  Phrenic nerve stimulates diaphragm to contract and flatten  Chest cavity enlarges  Change in pressure causes air to be pulled in  Expiration  Breathing muscles relax  Lungs return to original size  Air forced out Pulmonary Ventilation Gas Transport  Oxygen in blood    Attached to hemoglobin in red blood cells Released to cells as needed Carbon dioxide mostly as carbonic acid  Amount formed regulates blood pH Clinical Aspects of Respiration  Pulmonary function affected by conditions that:    Cause resistance to air flow Limit proper expansion of chest Conditions directly affecting respiratory system:      Infection Injury Allergy Aspiration Cancer Changes in Ventilation  Changes in ventilation affect pH of blood   Alkalosis = too much carbon dioxide exhaled by hyperventilation (blood too alkaline) Acidosis = too little carbon dioxide exhaled by hypoventilation (blood too acidic) Infections  Pneumonia    Caused by several different microorganisms Leading cause of death in debilitated patients Tuberculosis   Caused by Mycobacterium tuberculosis Symptoms:       Fever Weight loss Weakness Cough Hemoptysis (sputum with blood) Influenza  Viral disease of respiratory tract Emphysema   Overexpansion and destruction of alveoli Causes:    Exposure to cigarette smoke or pollution Chronic infection Classified under chronic obstructive pulmonary disease (COPD) heading Asthma    Narrowing of bronchial tubes Main factor may be irritation caused by allergy Symptom of wheezing indicated by:     Constriction of bronchial tubes Edema of bronchial linings Accumulation of mucus Extreme “attacks” may result in:   Dyspnea Cyanosis Disorders of Pleura  Pleurisy = inflammation of pleura, usually with infection   Accumulation of substances between layers of pleura lead to other conditions:      Main symptom is pain which causes rapid, shallow breathing Pneumothorax Empyema Hemothorax Hydrothorax Fluids removed by thoracentesis Lung Cancer  Leading cause of cancer-related deaths    Major risk factors:    Usually cannot be detected early Metastasizes rapidly Cigarette smoking Other forms of cancer Diagnosed by:     Radiographic studies CT scans Sputum examination Bronchoscope Respiratory Distress Syndrome    Occurs in premature infants Results from lack of surfactant in lungs Acute respiratory distress syndrome   May result from:  Trauma  Allergic reactions  Infection  Other causes Involves edema that can cause respiratory failure Diagnosis  Methods for diagnosing respiratory disorders:       Radiographs CT scans MRI scans Lung scans Bronchoscopy Tests of pleural fluid removed with thoracentesis Methods for diagnosing respiratory disorders  Examination of arterial blood gases Evaluating gas exchange, it measures: Carbon dioxide Oxygen Bicarbonate Blood pH  Pulse oximetry: Measure oxygen saturation of arterial blood  Pulmonary function tests: Spirometer measures volume of air moved with varying degrees of effort