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Anatomy & Physiology of Larynx Dr. Vishal Sharma Larynx (anterior) Larynx (posterior) Larynx (posterior) Larynx (lateral) Larynx (superior) Larynx (superior) Larynx (sagittal section) Larynx (sagittal section) Larynx (coronal section) Vocal fold Vocal fold Laryngeal Cartilages 3 single & 3 paired Single Paired Epiglottis Arytenoid Thyroid Corniculate (Santorini) Cricoid Cuneiform (Wrisberg) Cartilages (anterior) Laryngeal Cartilages Cartilages (posterior) Cartilages (posterior) Cartilage Histology Elastic: Epiglottis, corniculate, cuneiform & apex of arytenoid. Little or no calcification. Hyaline: Thyroid, cricoid & remaining arytenoid. Calcify as age advances. Ossification begins by 25-30 yr & is completed by 60 yr. Indirect Laryngoscopy Flexible Laryngoscopy LEFT RIGHT Laryngeal cavity 1. Laryngeal inlet 2. Laryngeal Vestibule 3. Laryngeal Ventricle 4. Rima glottis 5. Subglottis Pediatric Larynx • Conical in shape & subglottis is narrowest part • Positioned high (C3-C4) • Moves higher during swallowing allowing simultaneous breathing & feeding • Loose sub-mucosal tissues (swell up easily) • Soft cartilages that collapse easily Membranes & Ligaments • Extrinsic: connect thyroid cartilage & epiglottis with hyoid bone; cricoid cartilage with trachea. • Intrinsic: connect cartilages of larynx to each other. Extrinsic • Thyrohyoid membrane • Hyoepiglottic ligament • Cricotracheal ligament Intrinsic Intrinsic Intrinsic 1. Quadrangular membrane Ary-epiglottic ligament Vestibular ligament 2. Crico-vocal membrane Vocal ligament Cricothyroid membrane 3. Thyro-epiglottic ligament Oncological Divisions A. Supraglottis: laryngeal inlet to apex of ventricle B. Glottis: apex of ventricle to 10 mm below C. Subglottis: lower glottic border to lower cricoid border Subsites A. Supraglottis: 1. Epiglottis 2. Aryepiglottic folds 3. Ventricular bands 4. Laryngeal Ventricle B. Glottis: 1. True vocal cords 2. Anterior commissure C. Subglottis 3. Posterior commissure Intrinsic Muscles A. Acting on vocal cords Abduction Posterior crico-arytenoideus Adduction Lateral crico-arytenoideus Transverse inter-arytenoideus Thyro-arytenoideus externa Tension + lengthening Cricothyroid Relaxation + shortening Vocalis Intrinsic Muscles B. Acting on laryngeal inlet Opener Thyro-epiglottic Closer Oblique inter-arytenoideus Ary-epiglottic Extrinsic Muscles Primary Elevators Secondary Elevators Stylopharyngeus Mylohyoid Salpingopharyngeus Stylohyoid Palatopharyngeus Geniohyoid Thyrohyoid Digastric Depressors Sternohyoid Sternothyroid Omohyoid Posterior cricoarytenoid Lateral cricoarytenoid Transverse Inter-arytenoid Cricothyroid Thyroarytenoid externa + Vocalis Oblique Inter-arytenoid Spaces of Larynx Reinke’s space Pre-epiglottic space Para-glottic space Communications Shape of Glottis Shape of Glottis Quiet Respiration Forced Inspiration Inspiration Shape of Glottis Normal voice Whisper Normal phonation Whisper Mucous Membrane • Stratified squamous epithelium: Epiglottis (anterior surface + upper half of posterior surface), upper part of aryepiglottic folds & vocal cords • Pseudo-stratified ciliated columnar (respiratory) epithelium: Rest of laryngeal mucous membrane Nerve Supply Superior Laryngeal Nerve: • Internal: sensation to supraglottis & glottis • External: motor to cricothyroid muscle Recurrent Laryngeal Nerve: • sensation to subglottis • motor to all intrinsic muscles but cricothyroid Blood Supply Arterial supply: • Laryngeal br. of superior & inferior thyroid Venous drainage: • Superior thyroid vein internal jugular vein • Inferior thyroid vein innominate vein Lymphatic Drainage Supraglottis: via thyrohyoid membrane into upper deep cervical nodes & thyroid gland Subglottis: via cricothyroid membrane into pretracheal + lower deep cervical nodes Glottis: has no lymphatics Functions of Larynx 1. Protection of lower airway 2. Phonation (voice production) 3. Passage of air into lungs for respiration 4. Chest fixation by glottic closure Protection of lower airway a. 3-level below-upward closure of: vocal cords ventricular bands aryepiglottic folds b. Cessation of respiration: mediated by glossopharyngeal nv & deglutition centre. c. Cough reflex Voice Production 1. Voice activating air reservoir in lungs: affects voice intensity 2. Voice generation: affects voice pitch 3. Voice resonation: affects voice quality 4. Voice articulation: affects voice quality Voice Production Neuro-chronaxic theory (?) • Vibration of vocal fold muscles due to impulses generated from recurrent laryngeal nerves. Speed is regulated by acoustic center in brain. • Obsolete theory because: • muscle contraction not so fast to produce vibrations • even paralyzed vocal folds can produce phonation • passive phonation occurs in excised larynges Combined Aerodynamic & Myoelastic theory Proposed by Jan Willem van den Berg in 1958 Vocal cords kept approximated Subglottic blast of air opens vocal cords from below upwards & causes their passive vibration, producing sound Muscle tension + Bernoulli's effect closes vocal cords below upwards Cycle repeated Aerodynamic myoelastic theory (opening phase) Aerodynamic myoelastic theory (closing phase) Stroboscopic examination Voice generation High pitch = short, thin, tense, less elastic vocal cords Low pitch = long, bulky, relaxed, more elastic vocal cords Falsetto voice = tense vocal cords, only edge of vocal fold vibrates & body is relaxed, with small phonatory gap Falsetto voice Vocal cord cross-section Normal phonation Falsetto voice Glottis state in phonation • Voiceless (full air stream) • Breathy voice (murmur) • Slack voice • Modal voice: maximum vibration, sweet spot • Stiff voice • Creaky voice (restricted air stream) • Glottalized (blocked air stream) Glottis state in phonation Vocal Registers • Vocal fry register: lowest vocal register • Modal voice register: commonly used for speaking & singing • Falsetto register: one octave higher than modal voice register • Whistle register: highest voice register. Used by female singers Musical notes & octaves Guinness World records Georgia Brown (2006): • Highest vocal range from G2 to G10 • Highest vocal note (G10) Adam Lopez (2002): • Highest vocal note for male (C8) Tim Storms (2002): • lowest vocal note (8 Hz = two octaves below lowest B on a piano) Adam Lopez & Tim Storms Voice resonation • Oral & pharyngeal cavity S • Nasal cavity M, N, Ng In rhinolalia clausa: • M, N & Ng are uttered as B, D & G respectively In rhinolalia aperta: • B, D & G are uttered as M, N & Ng Organs of articulation Places of articulation Bilabial: both lips Labio-Dental: lips + teeth Dental: teeth + tip of tongue Alveolar: alveolus + tip of tongue Palatal: hard palate + tongue blade Retroflex: tongue tip + hard palate Velar: tongue base + soft palate Glottal: produced in glottis Places of articulation Sound production Bilabial P, B, M, W Labio-Dental F, V; Dental T, D Alveolar T, D, N, L, S, Z Palatal Ch, Chh, J, Jh, Y Retroflex R, T, Th, D, Dh Velar K, Kh, G, Gh Glottal H, ?, uh-oh Chest fixation Closure of glottis helps in raising intra-thoracic & intra-abdominal pressure required for: • Coughing Vomiting • Defecation Micturition • Climbing Weight-lifting • Labour Thank You