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THE INTEGUMENTARY SYSTEM Skin and its Derivatives TYPES OF MEMBRANES Epithelial + Connective Tissue Serous Cutaneous Mucous Connective Tissue Synovial Serous Membranes Line body cavities that have no openings to outside. Secrete watery fluid. Simple squamous epith + loose CT Mucous Membranes • Line cavities that lead to outside. • Secrete mucus for protection. • Epithelium + Loose CT Serous, Mucous Membranes Synovial Membrane Lines joint cavities at articulations. Loose CT + elastic fibers + adipose tissue Cutaneous Membrane Stratified squamous epithelium + CT + muscle + nervous tissue Functions of Skin • Protects from injuries • Acts as barrier and regulates what enters/leaves body. • Regulates body temperature. • Synthesizes, stores vitamins. • Sensory functions EPIDERMIS Stratum corneum Stratum lucidum** Stratum granulosum Stratum spinosum Stratum basale (germinativum) **Thick skin only Stratum Basale • • • • • Lowest epidermal layer, near dermis Good nutrient supply Reproduces by mitosis Cuboidal, columnar in shape Moves to upper epidermis in 27 days. Stratum Basale Stratum Spinosum • • • • Living cells Dividing 8-10 cells thick Polygonal in appearance Stratum Spinosum Stratus Granulosum, • • • • • Poor nutrient supply. Flatten layer of cells. 3-5 cells thick. No cell division. Keratin accumulates. Lucidum • Found only in very thick skin. • Translucent. • Highly keratinized. • Dead cells Stratum Corneum • • • • • 25-30 cells thick. Cells are filled with keratin and hardened. Sloughed off. Outer most layer of epidermis. Keratinocytes Layer Stratum Basale Stratum Spinosum Stratum Granulosum Stratum Lucidum Stratum Corneum Superficial or Deep Layer? Characteristics Are cells Seen in keratinized THIN in this skin layer? too? DERMIS Irregular Dense Connective Tissue Collagenous fibers Dermis Sweat gland Sebaceous gland Arrector pili muscle Blood vessels Hair Follicle Sebaceous Gland Hair Follicles Sweat Gland Types of Sweat Glands (Sudoriferous Glands) • Merocrine glands: release fluid by exocytosis • Eccrine – Most common – Secretion is mostly water with solutes – Cools body down • Apocrine – Develops scent as bacteria metabolize secretion – Stimulated when frightened, during pain, during emotional upset Hypodermis (Subcutaneous) Recognized by adipose tissue. Sensory Structures of Dermis • Deep touch/pressure: Pacinian corpuscles • Light touch/pressure: Meisner’s corpuscles • Warm temperature: Free nerve endings • Cold temperature: Free nerve endings • Pain: Free nerve endings Melanocyte Melanocyte • Produces melanin for protection from UV radiation. • Responsible for skin color. • Melanoma. Melanoma Basal Cell Carcinoma Untreated….. Actinic Keratosis Caused by sun damage. Can lead to squamous cell carcinoma. PSORIASIS MAP SHOWING SKIN COLOR DISTRIBUTION Qui ck Ti me™ and a Graphi cs decompress or are needed to s ee this pi cture. EVOLUTION OF SKIN COLOR • Balance between – Need for protection against UV radiation which Causes skin cancer Destroys folate (vitamin B) – Need for UV to produce vitamin D for calcium absorption