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CCNE Nano-Bio Seminar Series Presents Paul Yager, PhD Professor Department of Bioengineering University of Washington Seattle, WA Integration of Paper Microfluidic Methods for Detection of Infectious Diseases for Low Resource Settings Thursday, September 11, 2014 Seminar & Discussion: 5:30 pm – 6:30 pm Beckman Building, Munzer Auditorium http://cmgm.stanford.edu/munzer/location.html Reception: 6:30 pm – 6:50 pm Lobby of Munzer Auditorium Abstract Two-dimensional paper networks (2DPNs) are a new class of devices that allow complex chemical processing in a very low-cost format. We have, for the last 6 years, been learning how to translate what we have learned about point-of-care diagnostic technologies in conventional microfluidics into the language of porous media. The wicking of fluids in porous materials (like paper, nitrocellulose membranes, etc.) allows us to discard pumps, which permits great savings in complexity and cost, and the potential to perform complex tests without any permanent instruments. However, there are many physical and chemical differences between open ducts and porous media--we have put a good deal of effort into understanding the performance and design rules of simple paper systems. Currently, the two primary applications for this technology in our lab are for detection of pathogens that cause human infectious disease: 1) highly-sensitive multiplexed protein binding assays (of which immunoassays are a class) for detection of influenza, and 2) ultrasensitive rapid multiplexed isothermal nucleic acid amplification assays for detection of pathogens by DNA and RNA. All assays are designed to operated by untrained users in low resource settings (e.g. include the home), and employ visible optical readout that can be captured and quantified using camera-equipped cellular phones. Sponsored by: Center for Cancer Nanotechnology Excellence and Translation (CCNE-T) Program NIH/NCI U54 Hosted by: Dr. Sanjiv Sam Gambhir, Departments of Radiology & Bioengineering