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University of Virginia Health System Medical Laboratories “Quality You Expect, Service You Deserve” LABORATORY MEDICINE UPDATE June 7, 2011 Discontinuation of Total Kappa and Total Lambda Light Chain Assays Quantitative measurements of total kappa and lambda light chains are no longer recommended as part of the workup for plasma cell disorders. Accordingly, we are discontinuing these assays and recommend free kappa and free lambda assays (1), which are currently orderable, in addition to serum/urine protein electrophoresis and quantitative immunoglobulin determinations. When evidence of abnormal immunoglobulins is identified by protein electrophoresis, immunofixation will be performed to determine the monoclonal heavy and light chain components. 1. Dispenzieri A, Kyle R, Merlini G et al. International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia. 2009;23:215-24. New Link to Laboratory Test Handbook Due to recent Web changes, the direct link to the Clinical Pathology test listing is now: http://www.healthsystem.virginia.edu/alive/medlabs/LabTestSearch/LabTests_Search.cfm New Coagulation Tests in Core Laboratory The Coagulation Laboratory now offers testing to assess platelet inhibition due to Aspirin and P2Y12 inhibitors such as clopidogrel, prasugrel, and ticlopidine. A special Greiner citrated blue top is required for collection of blood for these assays. If you need to acquire a Greiner blue top tube for collection, please call Medical Laboratories Customer Service at 4-LABS (4-5227) for the special tubes and collection instructions. For questions regarding the assay, please call the Special Coagulation Laboratory at 4-8007. Page 1 of 1