Download tuberculosis epidemiological situation in ukraine

Lecture 1
Stomat
Determination of tuberculosis
as a scientific and practical
problem.
History of development of
phthisiology. Epidemiology
of tuberculosis.
Description of exciter.
Pathogenic of tuberculosis.
Organization of fight against
tuberculosis in Ukraine.
Prof. L.A. Hryshchuk
2013

The World Health Organization (WHO)
proclaimed tuberculosis to be the global danger.
According to its forecasts there will be 90 million new
tuberulosis cases in the world during the decade. Of
those who will fall ill approximately 30 million people
may die in the current decade unless the reaction to
this global problem radically improves.
Nowadays the world scientists distinguish threeunion
tuberculosis epidemic: the first is the epidemic of
typical tuberculosis that is treated well; the second is
the epidemic of chemioresistant tuberculosis and the
third one is the epidemic of tuberculosis and the AIDS.
Europe,1990-2010
Rate per 100.000 population/year
Rate per 100.000 population/year
Incidence
Rate per 100.000 population/year
TB/HIV incidence,
TB/HIV incidence
Prevalence
MDG target for prevalence
Mortality
MDG target for mortality
Source: Global TB control report, 2011
3
The incidence of TB has slowly declined
during the past years, reaching 48
(confidence intervals 44-50) per 100
000 population in 2009.
 However there is a big discrepancy
between east and west.
 The TB prevalence decreased from 96
(confidence intervals 70-130) to 63
(confidence intervals 49-81) per 100
000 population between 1990 and 2009
against a target of below the prevalence
of 48 set out in the target for 2015.
 Mortality from TB must further decline,
from 6.9 (confidence intervals 5.7-8.3)
per 100 000 persons in 2009 to 6 by
2015.

TB incidence
TB/HIV incidence, 2010
6
We will start with the
patient since they are
typically the source of
infection. This slide
shows a violent sneeze
caught on film by high
speed photography
showing large liquid
droplets.
Most of these large,
visible droplets will fall
to the ground. However,
the small droplet nuclei
that can reach the deep
lung are not visible and
are 1:5 micro meters in
size.
According to the WHO criteria from 1995
tuberculosis epidemic has been registered in Ukraine in
so far as tuberculosis patients comprise over 1 % of the
total number of the population.
The statistics of sickness in all the forms of
tuberculosis in 2009 was 72,7 persons per 100 thousand
of the population.
Alarming is the fact that tuberculosis “has turned
younger”, its number among children, able-bodied and
reproductive ages increases.
HISTORICAL REVIEW
Tuberculosis, as an illness, is known since ancient times.
The principal clinical manifestations of tuberculosis are described
still by Hippocrate, Gallen, Avizenna.
The fact that tuberculosis is infectious was confirmed by
Fracastoro in the 16th century.
It was Morton who published the first monograph
“Phthisiology or a treatise on the phthisis”
( R. Morton, 1689) and named a science of
tuberculosis “phthisiology” (from the Greek word
“phthisis” – which means exhaustio. In the 17th
century the French anatomist Sylviy, describing
the hurt lungs of patients who had died of phthisis,
used the word “hump” (tuberculum).
However, it was only in the 19th century in France that pathologists
and therapeutists G. Bayle, and then R. Laennec proved the hump
and caseous necrosis to be specific morphological substratum of
tuberculosis. In 1865 the French physician B. Villemin
experimentally proved the infectious nature of tuberculosis, though
he could not reveal the pathogene.
In 1882 the German bacteriologist Robert Koch (fig. 1) discovered the
pathogene of tuberculosis, which was named bacillus of Koch (BK). He was also
the first who obtained tuberculin with the hope to successful treatment of
tuberculosis patients. These expectations of the scientist did not come true,
nevertheless for the purpose of diagnostics tuberculine has been used for over 100
years.
Fig. 1. R.Koch (1843-1910)
M.I. Pyrohov studied clinico-morphological properties of
tuberculosis of various localization and for the first time described
typhoid form of miliar tuberculosis, histologic structure of
tuberculous granuloma. Further study of pathomorphological
alterations at lungs tuberculosis was proceeded by A.I. Abrykosov
and A.I. Strukov.
In 1887 R. Philip in Edinburgh (Scotland)
founded the world first antituberculosis
dispansery. This new institution offered the
patients not only medical but also social help,
which later on laid the foundation of the
organization of antituberculosis service also in
this country.
In 1882 in Rome C. Forlanini offered artificial
pneumothorax for treating lung tuberculosis
patients.
In 1895 Wilhelm Kondrat Roentgen discovered X-rays, which have
been widely used in medicine up to today. Actually, it’s known well
enough that X-rays were discovered by Ukrainian scientist Ivan
Pulyuy (1845-1918) from Halichina 17 years earlier. However, he
made his announcement about the discovery 7 days after Mr.
Roentgen had made his one, thus the preference was given to Mr.
Roentgen who received Nobel Prize.
An important achievement of the start of the 20th century was the
creation by the French scientists Calmette and Guerin (1919) of the
antituberculosis vaccine BCG (Bacilles Calmette, Guerin). Since
1935 mass vaccination began. At the same time in 1924 Abre in
Brazile introduced the method of fluorographic observation of the
population for active revealing lung tuberculosis patients.
THE WORLD TUBERCULOSIS
EPIDEMIOLOGICAL SITUATION
More than 6 billion people live on our planet now. More
than 2 billion of them suffer from various diseases. Every
fifth earthman lives in extreme need and poverty, which has
become the main death reason in the world. Today
tuberculosis is the most widely spread infectious disease
which ranks first as to the deathrate among the people from
infectious pathology. Moreover, new misfortunes are added.
In 2007 A.D. there are 30-40 million carriers of the human
immunodeficite virus in the world and 10 million AIDS
patients, who increase the number of tuberculosis patients
considerably.
According to the data of the World Health
Organization half of the globe population is
infected with tuberculosis mycobacteria. In
some countries infectiousness of the
population with tuberculosis reaches 80-90 %.
This is also true about Ukraine. Every year
each tuberculosis patient can infect 10-15 and
more persons of which 5-10 % will catch the
disease.
Every year 7-10 million people fall ill with
tuberculosis all over the world, including 4-4,5 mln.
– with bacterial secretion and about 3 mln. adults
die of it (of these 97 % – in the developing
countries) and approximately 300 thousand
children. The total number of tuberculosis patients
reaches 50-60 mln.
Nowadays tuberculosis is the most menacing illness
for the whole mankind. It kills more patients
worldwide than all the infectious and parasitic
illnesses taken together. Present tuberculosis
epidemic has acquired the global scales. In many
parts of the world tuberculosis epidemic is beyond
the control.
The highest tuberculosis statistics of sickness is
noted in African and Asian regions, in the countries
of the Pacific Ocean coast. Tuberculosis epidemic
situation got worse in the countries of Europe too,
especially in the countries of the former Socialist
community.
In 2007 the lowest tuberculosis index was
registered in the highly developed countries, such
as Malta (4,2), Sweden (5), Norway (5,5), Iceland
(6,2), Italy (8,4 per 100000 of the population), the
highest – in Romania (114,6), in the former Soviet
Union, as in Kirgistan (127,8), Kazakhstan (126,4),
Georgia (124,4), Turkmenistan (86,1 per 100.000 of
the population) (fig.3).
TUBERCULOSIS EPIDEMIOLOGICAL
SITUATION IN UKRAINE
If one looks into the past, he will see that from 1965 to
1990 the morbidity of all clinical forms of tuberculosis
decreased 3,6-fold or from 115,4 per 100 thousand
population to 32,0 per 100 thousand population; the deathrate for these years decreased 3,3-fold or from 27,1 per 100
thousand population to 8,1 per 100 thousand population.
However, starting from 1990 a crucial moment occurred in
tuberculosis epidemiological situation, it started to grow,
which is vividly reflected in epidemiological indices.
Morbility on tuberculosis and HIV in Ukraine
The statistics of morbidity in all forms of tuberculosis in
Ukraine from 1990 to 2011 increased from 32 to 68,4 per
100 thousand population/
100
80
60
40
20
0
1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2011
ВІЛ
Туберкульоз
The pathogenesis of
tuberculosisInfection with
Mycobacterium tuberculosis,
the causative agent, follows
a relatively well-defined
sequence of events. The
infectious bacilli are inhaled
as droplets from the
atmosphere. In the lung, the
bacteria are phagocytosed by
alveolar macrophages and
induce a localized
proinflammatory response
that leads to recruitment of
mononuclear cells from
neighbouring blood vessels.
These cells are the building
blocks for the granuloma, or
tubercle, that defines the

The granuloma consists of a kernel of infected
macrophages, surrounded by FOAMY GIANT CELLS and
macrophages with a mantle of LYMPHOCYTES
delineating the periphery of the structure.

This tissue response typifies the 'containment' phase of
the infection, during which there are no overt signs of
disease and the host does not transmit the infection to
others. Containment fails after a change in the immune
status of the host, which is usually a consequence of old
age, malnutrition, or HIV-co-infection.

Under such circumstances, the centre of the granuloma
undergoes caseation and spills viable, infectious bacilli
into the airways. This leads to development of a
productive cough that facilitates aerosol spread of
infectious bacilli.
Pathogenesis of
Tuberculosis

Infection with Mycobacterium tuberculosis, the
causative agent, follows a relatively well-defined
sequence of events. The infectious bacilli are inhaled
as droplets from the atmosphere. In the lung, the
bacteria are phagocytosed by alveolar macrophages
and induce a localized proinflammatory response that
leads to recruitment of mononuclear cells from
neighbouring blood vessels. These cells are the
building blocks for the granuloma, or tubercle, that
defines the disease. The granuloma consists of a
kernel of infected macrophages, surrounded by
FOAMY GIANT CELLS and macrophages with a
mantle of LYMPHOCYTES delineating the periphery of
the structure


This tissue response typifies the
'containment' phase of the
infection, during which there are
no overt signs of disease and the
host does not transmit the
infection to others. Containment
fails after a change in the immune
status of the host, which is usually
a consequence of old age,
malnutrition, or HIV-co-infection.
Under such circumstances, the
centre of the granuloma undergoes
caseation and spills viable,
infectious bacilli into the airways.
This leads to development of a
productive cough that facilitates
aerosol spread of infectious bacilli.
Thin section transmission electron micrograph of Mycobacterium
tuberculosis
ORGANIZATION OF ANTITUBERCULOUS
ACTIVITY IN THE PERIOD OF
TUBERCULOSIS EPIDEMY
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Tuberculosis is a social disease and is a mirror of socialeconomic prosperity of the state and the well-being of its
people, therefore antituberculous measures under present
conditions must be taken on the national level by the
government of the country.
At present time, the principal task in fighting tuberculosis in
Ukraine is to take the epidemy of the illness under control (I
stage), to stabilize the epidemiological indices (infestation,
morbidity, sickliness and death rate) of tuberculosis (2
stage), and then their gradual decrease (3 stage).
For the successful organization of antituberculous measures
close cooperation of the medical system, sanitaryepidemiological service and the organs of the state power is
necessary. The general organization and methodological
guidance of antituberculosis activity in this country is
realized by the Ministry of Health Protection of Ukraine and
Acad. F.G.Yanovsky Ukrainian phthisiology and
pulmonology research institute (scheme 1).
STRUCTURE OF ANTITUBERCULOSIS SERVICE
IN UKRAINIAN
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The Ministry of Health Protection
Acad. F.G.Yanovsky Ukrainian phthisiology and
pulmonology research institute
Regional of antituberculous dispensary
Distric(town) of antituberculous dispensaries
Tubcabinet
At child’s policlinic
At policlinic
At medical parts
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Antituberculous dispensary (Engl. dispensation –
distribution) is a specialized medicative-prophylactic
institution, which work is aimed at lowering
morbidity, sikliness, infestation with tuberculosis and
death rate caused by it as well as at conducting a
complex of organizational and methodical,
prophylactic antituberculous measures among the
district population.
The main tasks of an antituberculous dispensary are:
1) prophylaxis;
2) early revealing;
3) treatment of tuberculosis patients;
4) registration of groups of tuberculosis patients and
contingents of persons
DISPENSARY CATEGORY

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
Contingents of antitubercular dispensaries are
divided into categories, which enables to
examine them differentially, define the
treatment tactics, perform prophylactic and
rehabilitation actions.
Contingents of adult persons, children and
teenagers due to being observed at an
antitubercular dispensary, are divided into 5
dispensary categories: 1, 2, 3, 4 and 5.
To 5 categories (Cat 5) are referred
dispensary contingents of risk to disease to a
tuberculosis and its relapse.
CLINICAL CLASSIFICATION OF
TUBERCULOSIS

I. TYPE OF TUBERCULOUS PROCESS
1. First diagnosed tuberculosis – FDTB
(date of its ascertainment)
 2. Tuberculosis relapse – TBR (date of its
ascertainment)
 3. Chronic tuberculosis – CTB (date of its
ascertainment)

II. CLINICAL FORMS OF
TUBERCULOSIS

A 15.-A 16. – Lung tuberculosis (LTB) (from a facultative
designation of the form of injury)
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A 15.-16.Primary tuberculous complex
A 19.- part
Disseminated lung tuberculosis
A 15-16.Nidus lung tuberculosis
A 15-16.Infiltrative lung tuberculosis
A 15-16.Caseous pneumonia
A 15-16.Lung tuberculoma
A 15-16.Lung fibrous-cavernous tuberculosis
A 15-16.Lung cirrhotic tuberculosis
A 15-16./J65
Tuberculosis of respiratory organs
combined with dust professional lung diseases
(coniotuberculosis)
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III. CHARACTERISTIC OF
TUBERCULOUS PROCESS
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1. Localization of defect
Localization of defect in lungs according to the
numbers (names) of segments, names of lung
sections, and in other organs and systems –
according to anatomical names of localization of
a failure.
2. Presence of destruction
(Destr +) destruction is present
(Destr -) destruction is not present
facultatively it is necessary to specify a phase of
tubercular process:
infiltration, decay (Destr +), sowing;
suction, condensation, scarring, calcination.
3. Etiologic confirmation of tuberculosis
diagnosis
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(MBT +) it is confirmed by the results of bacteriological analysis (code A 15), in this
case to specify:
(M +)
positive result of sputum analysis on acid-resisting bacteria (ARB);
(C 0)
cultural analysis was not done;
(C -)
negative result of cultural analyses;
(C +)
positive result of cultural analyses, in that case to specify:
(Resist 0) MBT resistance to preparations of I line was not analysed;
(Resist -) resistance to preparations of I line has not been established;
(Resist +) ( abbreviation of antitubercular preparations of I line) resistance МBТ to
preparations of I line has been established (in brackets to list all the preparations of I
line to which resistance has been determined).
(Resist II0) MBT resistance to preparations of II line was not analysed;
(Resist II-) resistance to preparations of II line has not been established;
(Resist II+) ( abbreviation of antitubercular preparations of II line) resistance МBТ to
preparations of I line has been established (in brackets to list all the preparations of I
line to which resistance has been determined).
( МBТ-) is not confirmed by the results of bacteriological analysis (the code A16), in
this case to specify:
(S 0) sputum was not investigated;
(S -) negative result of sputum analysis on acid-resisting bacteria (ARB);
(C 0) cultural analysis was not done;
(C- ) negative result of cultural analysis;
(Hist 0) histologic analysis was not carried out;
(Hist -) is not confirmed by the results of histologic analysis (the code A 16);
(Hist +) it is confirmed by the results of histologic analysis (the code A 15).
IV. COMPLICATIONS OF
TUBERCULOSIS

Complications of lung tuberculosis (LTB):
haemoptysis, lung haemorrhage, spontaneous
pneumothorax, lung insufficiency, chronic lung
heart, atelectasis, amyloid disease etc.

Complications of extrapulmonary
tuberculosis (EpTB): bronchus stenosis,
pleura empiema, fistulae (bronchial, thoracic),
renal (adrenal) insufficiency, sterility,
commissure, ankylosis, amyloid disease etc.
V. CLINICAL AND DISPENSARY
CATEGORY OF THE REGISTRATION
PATIENT
Category 1 (Cat 1) First diagnosed
tuberculosis with bacterial excretion (FDTB МBТ
+), and also other grave and wide-spread forms
of the disease without bacterial excretion (FDTB
МBТ-)

Category 2 (Cat 2) Relapses of
tuberculosis (RТB МBТ +) and (RТB МBТ-) and
first diagnosed tuberculosis inefficiently treated (
FDTB IT МBТ +) and (FDTB IT МBТ-)
 Category 3 (Cat 3) First diagnosed
tuberculosis with the limited process, without
bacterial excretion (FDTB МBТ-) and
tuberculosis of unstated localization in children
(tubintoxication)
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Category 4 (Cat 4) Chronic tuberculosis (CТ)
of various localizations МBТ + and МBТCategory 5 (Cat 5) Risk groups to tuberculosis
or its reactivation
Group 5.1 residual changes of cured tuberculosis,
Group 5.2 contact persons,
Group 5.3 adults, tuberculosis patients of
doubtful localization,
Group 5.4 children and teenagers with latent
tubinfection, persons from risk group, and also
children who were not vaccinated in the
neonative period and with postvaccinal
complications.
Group 5.5 children and teenagers whose etiology
of sensitivity to tuberculin it is necessary to
specify, or character of changes in the lungs with
VII. TUBERCULOSIS
CONSEQUENCES
Residual changes after healed lung
tuberculosis:
fibrous, fibrous-nidus, bullous-dystrophic,
calcinates in lungs and lymphatic nodes,
pleuropneumosclerosis, cirrhosis, consequences
of surgical intervention (with the indication of
the type and the date of an operation), etc.
 Residual changes after healed tuberculosis
of extrapulmonary localisation: cicatricial
changes in various organs and their
consequences, calcinosis, consequences of
surgical intervention (with the indication of the

ORGANIZATION OF ANTITUBERCULOUS
ACTIVITY IN THE PERIOD OF
TUBERCULOSIS EPIDEMY



Tuberculosis is a social disease and is a mirror of socialeconomic prosperity of the state and the well-being of its
people, therefore antituberculous measures under present
conditions must be taken on the national level by the
government of the country.
At present time, the principal task in fighting tuberculosis in
Ukraine is to take the epidemy of the illness under control (I
stage), to stabilize the epidemiological indices (infestation,
morbidity, sickliness and death rate) of tuberculosis (2
stage), and then their gradual decrease (3 stage).
For the successful organization of antituberculous measures
close cooperation of the medical system, sanitaryepidemiological service and the organs of the state power is
necessary. The general organization and methodological
guidance of antituberculosis activity in this country is
realized by the Ministry of Health Protection of Ukraine and
Acad. F.G.Yanovsky Ukrainian phthisiology and
pulmonology research institute (scheme 1).
STRUCTURE OF ANTITUBERCULOSIS SERVICE
IN UKRAINIAN








The Ministry of Health Protection
Acad. F.G.Yanovsky Ukrainian phthisiology and
pulmonology research institute
Regional of antituberculous dispensary
Distric(town) of antituberculous dispensaries
Tubcabinet
At child’s policlinic
At policlinic
At medical parts






Antituberculous dispensary (Engl. dispensation –
distribution) is a specialized medicative-prophylactic
institution, which work is aimed at lowering
morbidity, sikliness, infestation with tuberculosis and
death rate caused by it as well as at conducting a
complex of organizational and methodical,
prophylactic antituberculous measures among the
district population.
The main tasks of an antituberculous dispensary are:
1) prophylaxis;
2) early revealing;
3) treatment of tuberculosis patients;
4) registration of groups of tuberculosis patients and
contingents of persons

Other very important tasks of an antituberculous
dispensary are revealing, registration and treating
tuberculosis patients. The results of treating
tuberculosis patients to a considerable degree
depend on the disease being timely revealed. In this
connection, firsty diagnozed tuberculosis patients are
divided into three groups: timely, untimely and lately
revealed. For children and teenagers the fourth group
is separated – early revealing.

The main criteria of dividing patients into groups are
the character of a specific process, the presence or
absence of destruction (cavern) and bacterial
excretion, peculiarities of the prognosis at treatment,
the degree of a patient’s danger for healthy persons.
Children and teenagers, in whom the
following factors are diagnosed, compose
a group of early revealed:
 1) tuberculin test range;
 2) primary tubinfestation;
 3) hyperergic Mantoux test;
 4) tuberculous intoxication.

DISPENSARY CATEGORY



Contingents of antitubercular dispensaries are
divided into categories, which enables to
examine them differentially, define the
treatment tactics, perform prophylactic and
rehabilitation actions.
Contingents of adult persons, children and
teenagers due to being observed at an
antitubercular dispensary, are divided into 5
dispensary categories: 1, 2, 3, 4 and 5.
To 5 categories (Cat 5) are referred
dispensary contingents of risk to disease to a
tuberculosis and its relapse.