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LESSON 5:
Protein Structure and Function: A Molecular Murder Mystery
PowerPoint slides to accompany
Using Bioinformatics:
Genetic Research
Chowning, J., Kovarik, D., Porter, S., Grisworld, J., Spitze, J., Farris, C., K. Petersen, and T.
Caraballo. Using Bioinformatics: Genetic Research. Published Online October 2012. figshare.
http://dx.doi.org/10.6084/m9.figshare.936568
Molecular Diagnostics Researcher
James Ferrenberg
Place of Employment:
University of Washington
Molecular Diagnostics Lab
Virology Division
Type of Work:
Develop tests to diagnose
different types of viral infections
Discovery is really exciting and there is nothing cooler
(in my job) than designing an assay and finding it works
great and generates important data.
Mitochondria:
The Powerhouse of the Cell
• Present in almost
all cells.
• Inner membrane
contains the
electron transport
chain.
– Metabolizes sugar
and fats into ATP.
• Mitochondrial
DNA (mtDNA).
Source: Wikimedia Commons.
Food (Sugar and Fats) Go In
ATP Comes Out
Source: Roxxychan, Wikimedia Commons.
3D Structure of the Cytochrome c
Oxidase Complex
Intermembrane Space
Inner
Mitochondrial
Membrane
Matrix
Source: Tsukihara et al. 1996. Science 272:1136.
Molecular Diagnostics Researcher
James Ferrenberg
Place of Employment:
University of Washington
Molecular Diagnostics Lab
Virology Division
Type of Work:
Develop tests to diagnose
different types of viral infections
Discovery is really exciting and there is nothing cooler
(in my job) than designing an assay and finding it works
great and generates important data.
CAREERS IN SPOTLIGHT:
Molecular Diagnostics Researcher
What do they do?
Develop tests and methods to identify a disease or the predisposition
to a disease by analyzing the DNA or RNA of an infectious organism
(virus, bacteria, or parasite).
What kind of training is involved?
Associate’s degree and/or Bachelor’s degree
What is a typical salary for a Molecular Diagnostics Researcher?
Starting: $35,000-$45,000/year ($17.50-$22.00/hour)
Up to: $55,000-$65,000/year ($26.00-$31.00/hour)
Source: Genome Technology Salary Survey 2010