* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Lentivirus - The Evergreen State College
Survey
Document related concepts
Plasmodium falciparum wikipedia , lookup
Ebola virus disease wikipedia , lookup
Marburg virus disease wikipedia , lookup
Hepatitis C wikipedia , lookup
Microbicides for sexually transmitted diseases wikipedia , lookup
Sarcocystis wikipedia , lookup
Orthohantavirus wikipedia , lookup
Neisseria meningitidis wikipedia , lookup
Human cytomegalovirus wikipedia , lookup
Diagnosis of HIV/AIDS wikipedia , lookup
Herpes simplex virus wikipedia , lookup
West Nile fever wikipedia , lookup
Hepatitis B wikipedia , lookup
Henipavirus wikipedia , lookup
Transcript
Equine Infectious Anemia Andrea Jensen & Emily French Discovery History Horsey AIDS?… NOT EIAV FIV HIV Species Infects Horses Macrophages Cats T Cells Humans T Cells Primary Symptom Anemia Immunosuppression Immunosuppression Lentiviruses Retrovirus Family Single Strand (+) RNA virus Contains 2 copies Can infect non-dividing cells Contains regulatory proteins Latent or active viral states Spread by blood and other bodily fluids Long lived virus leading to reservoir for persistent infection Virus type present in many vertebrate species The next 30 minutes of your life… Transmission Pathology Testing and Control Vaccine research, EIAV/FIV What does it mean to Me? Transmission Vicki 15 min of fame Viral Life Cycle Primary Pathology Mature RBC’s destroyed by immune system Maturation of RBC precursor cells prevented Other EIAV Symptoms Depression Fever Enlarged Lymph Nodes Weakness Weight Loss Anorexia Edema Nasal Discharge DEATH How EIAV Stacks Up HIV “generally” fatal FIV is “Kitty AIDS” EIAV has 30% mortality So now you know….. What EIAV is and what it means for the horse. But what are we doing about it? Mandatory Testing Federally Mandated Control Measures Vaccine Research Current Testing • Agar gel immunodiffusion test (AGID or Coggin’s) • Competitive enzyme-linked immunosorbant assay (cELISA) AGID / Coggin’s cELISA Control Measures Life-long quarantine Slaughter Research Euthanasia What this means is… 70% of horses that contract EIAV would effectively manage the infection…. But….. 100% of horses who have a positive Coggin’s Test will die as a result of the test. Vaccines No. Yes. Well, Maybe… Why do we even care? Vaccine Research Therapeutic Vectors Immune System The End