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The Cardiovascular System •Your Heart and Stuff The Cardiovascular System includes the heart, blood vessels, and blood. Cardiology- the study of the heart and the diseases associated with it. Functions 1. 2. 3. to supply cells & tissues with oxygen to circulate substances & nutrients to remove wastes (CO2 & urea) from cells and tissues. Heart Coverings Pericardium – covers the heart, has 3 layers Fibrous pericardium - outermost Parietal pericardium - middle (Pericardial cavity) Visceral pericardium (continuous with epicardium) – innermost Pericardial sac surrounds the heart is made up of fibrous and parietal pericardium The Heart Wall (3 layers): epicardium (visceral pericardium) – reduces friction 2. myocardium - cardiac muscle tissue (bulk of heart) 3. endocardium – smooth inner lining of heart chambers and valves. 1. Heart Chambers The upper chambers – atria (atrium) blood flows here 1st. Pumps to ventricles The lower chambers – ventricles, pump blood out to body or lungs. The right side of your heart receives blood (deoxy) from the body and pumps it to the lungs. The left side of the heart receives blood (oxy) from the lungs and pumps it out to the body A solid wall-like septum separates the atrium and ventricle on the right from those on the left – so blood on one side never mixes with blood on the other side Why is this the right side? And this the left? Heart Valves Tricuspid Valve –btwn RA and RV Pulmonary Valve –allows blood to leave RV – Pulmonary means lungs. Bicuspid (mitral) Valve – btwn LA and LV Aortic Valve – allows blood to leave LV What color is blood? Blood when oxygenated is red However, deoxygenated is not blue as believed. It is actually a redish purple. It appears blue because the color is diffused looking through the skin This is also why veins typically appears almost green in African-Americans. Blood Flow Blood low on O2 (deoxygenated) enters Right Atrium through the superior and inferior venae cavae and coronary sinus Right Atrium wall contracts, and blood passes thru tricuspid valve into Right Ventricle (only adds 30% of vol. to RV) Right Ventricle contracts, and blood is forced thru pulmonary valve into pulmonary trunk divides into pulmonary arteries(left & right)to lungs Blood Flow cont. pulmonary arteries take blood to lungs; gas exchange occurs between blood and air in alveoli Carbon Dioxide is released. Oxygen is taken in. Blood goes from deoxygenated to oxygenated Freshly oxygenated blood returns to heart thru the pulmonary veins that lead to Left Atrium Blood Flow cont. Left Atrium wall contracts, and blood moves thru bicuspid valve into Left Ventricle Left Ventricle contracts, blood moves thru aortic valve and into the aortaaorta carries oxygenated blood to tissues Oxygen to tissues, Carbon Dioxide made in tissues released into blood Deoxygenated blood is sent back to heart thru superior and inferior vena cava Heart Sounds Heart sounds are produced by vibrations in the tissue associated with the closing of the valves. The first part of the heart sound (lubb) is heard during ventricular contraction when the valves between the Atrium & Ventricles closes. The closing causes the blood to stop flowing or back up causing a sound almost like waves crashing on a beach. They do not make a sound until they crash. Blood does not make a sound when flowing; only when it is stopped and crashes into heart valve. Heart Sounds cont’d The second part of the heart sound (dubb) happens during ventricular relaxation when the pulmonary and aortic valves snap shut Heart sounds give doctors an indication of how well the valves are functioning (ex: murmurs) Mitral Valve prolapse is usually identified by lubb-dubb-squish. The squish is the valve closing improperly and some blood still is leaking through. Cardiac Muscle fibers Cardiac fibers are highly branched, so when any part of the network is stimulated, the whole unit contracts This means the atria contract together and the ventricles contract together. Conduction of a cardiac impulse: Starts at the sinoatrial (S-A) node located in the RA The S-A node is self-exciting (no outside stimulation needed) and is rhythmic (initiates 70-80 impulses/min. in an adult) Called the “pacemaker” Conduction of a cardiac impulse: impulse generated by the S-A node causes the atria to contract impulse then travels to the atrioventricular (A-V) node located in the septum that separates the atria impulse is delayed as it passes thru the A-V node, allowing time for the atria to empty and the ventricles to fill with blood Conduction of a cardiac impulse: impulse then travels thru a bundle of fibers called the bundle of His located in the interventricular septum. The bundle of His gives rise to Purkinje fibers The Purkinje fibers extend down into the apex of the heart and curve upward thru the walls of the ventricles Conduction of a cardiac impulse: As impulse passes thru Purkinje fibers it stimulates the ventricular to contract Ventricles squeeze up from the bottom of the heart to squeeze blood out of heart. What would happen if there were no Purkinje fibers? No AV node? Blood vessels Arteries – carry blood away from heart; strong, thick; carry blood under high pressure; composed of mainly smooth muscle tissue – Not always oxygenated blood. Pulmonary artery takes deoxygenated blood to lungs away from heart. – Are typically deeper than veins Arteries subdivide into smaller tubes called arterioles. Blood vessels cont’d Capillaries – are the smallest blood vessels. They connect the arterioles with the venules. – Capillary walls are thin enough to allow substances to pass through such as O2 & CO2 – Capillaries are microscopic and are only big enough for one red blood cell to go through at a time. If you can see it; it is not a capillary. – 10-40 billion capillaries in your body – No cell is 1/100 of cm from a capillary Blood vessels cont’d Veins – Venules are small vessels that merge to form veins; parallel to arterioles – these vessels carry blood back to heart and are not always deoxygenated. – Venules and veins have thinner walls than arteries because the blood pressure is less. The Cardiac Cycle The series of events that constitute a heartbeat – The atrial walls contract; the ventricle walls are relaxed – The ventricle walls contract; the atrial walls relax – Both the atria and the ventricles relax – Ventricle contractions control blood pressure – Contracting ventricles– systole – Relaxation ventricles - diastole Blood Pressure The force blood exerts against the inner walls of blood vessels Usually refers to the pressure in the arteries supplied by the aorta When the ventricles contract blood moves into the aorta and pulmonary trunk, increasing pressure maximum pressure during ventricular contraction is called the systolic pressure Blood Pressure When ventricles relax, arterial pressure drops The lowest pressure before the next ventricular contraction is called the diastolic pressure If there’s a drop in blood pressure, walls of veins constrict, helping to maintain blood pressure by returning more blood to heart. (Less blood in veins if veins are smaller) This ensures a nearly normal blood flow even when as much as 25% of blood volume is lost. Taking Blood Pressure Normal Blood Pressure 120/80. Increase blood pressure until can not hear any flow because artery closed. Cuff pressure is greater than systole & diastole so blood vessels closed all the time. (Contraction & Relaxation) Taking Blood Pressure Let blood pressure come down until under 120. During Systole (contraction), pressure in arteries is greater than cuff, so artery open only during systole But during diastole (relaxation) pressure of cuff is greater than pressure in blood vessels so blood vessels are closed. Taking Blood Pressure The walls of the blood vessels go in and out causing turbulent flow of blood. Can hear turbulent flow because walls of arteries going in and out do to change in pressure. Under 80 silent because cuff pressure less diastole pressure so arteries stay open. Blood pressure always recorded as systolic = 120 diastolic 80 Pulse Rate The pulse rate is equal to the rate at which the ventricles contract or equal to heart rate. The pulse is the alternate expanding and recoiling of the artery walls. Pulse Blood vessel disorders Arteriosclerosis- degenerative disease in which the arteries lose elasticity; the vessels become brittle and can rupture easily; associated with fatty diet, genetics, lack of exercise, cigarette smoking, etc. Go to Heart Attack Then Blocking the Artery to watch video Arteriosclerosis Blood vessel disorders Aneurysm- a bulge in a blood vessel; this area of the blood vessel then weakens and may burst; can result from trauma, high blood pressure, infections, or genetic defects Aneurysm Blood vessel disorders cont’d Varicose veinsirregular dilations in superficial veins, especially of the legs; associated with prolonged increased back pressure, also with crossing legs. Blood vessel disorders cont’d Hypertension – high b.p.; caused by kidney disease, high Na+ intake, obesity, stress, arteriosclerosis; left ventricle works overtime so myocardium thickens, enlarging heartcoronary vessels can’t feed overgrowth so parts of heart die Disorders, cont. Anemia – condition in which the oxygen carrying capacity of the blood is reduced; symptoms: fatigue, intolerance to cold, and paleness. – Nutritional Anemia – inadequate diet, especially lacking in iron and vitamin B12 – Sickle-Cell Anemia – abnormal kind of hemoglobin results in cells shaped like a sickle (bent); they can rupture easily and often get stuck together; (genetic) Types of Anemia Pericarditis Inflammation of the pericardium and therefore an enlargement of the pericardial sac. This causes an increase in pressure on the outside of the heart and causes the heart to have to work harder Can cause heart attack Treatment – typically the fluid is drained with a needle into the pericardial sac. Pericarditis Blood 1. Connective tissue with liquid matrix. Carries oxygen, protects against infection, promotes clotting, and carries other vital substances Plasma 2. clear, straw-colored (yellowish) mixture of water (95%), amino acids, proteins, carbs, lipids, vitamins, hormones, electrolytes, and cellular wastes Red Blood Cells (Erythrocytes) contain hemoglobin (a protein that carries oxygen) made of Iron – loves oxygen – what causes blood to change colors. Red to purplish Also the chemical when changed which causes urine to be yellow and feces to be brown. formation of RBC (hematopoiesis) – in red marrow Blood continued 3. White Blood Cells (Leukocytes) Can squeeze through vessel walls and move through interstitial spaces via amoeboid movement Many kinds of white blood cells; all have different jobs. Protect against disease in 2 ways: – Phagocytize bacteria (eat up bacteria like pacaman) – Produce antibodies (proteins that destroy or disable foreign particles) 4. Platelets (Thrombocytes) Cell fragments that help close breaks in vessels and initiate formation of blood clots - (coagulation) Causes scabs and stops bleeding. 5 Types of White Blood Cells Red Blood Cells are erythrocytes ABO Blood Types Antigen- protein or carb on RBC surface –Presence or absence of antigens is an inherited trait 2 major antigens: Antigen A and Antigen B 4 possible antigen combinations: A only, B only, A and B, or neither A nor B ABO Blood Types Antibodies- proteins in the plasma that destroy foreign substances Antibodies develop about 2-8 months after birth – If antigen A is absent – a person develops anti-A antibody – If antigen B is absent – a person develops anti-B antibody ABO Blood Types, cont Blood Type Antigen Antibody A A Anti-B B B Anti-A AB A and B O Neither A nor B Neither Anti-A nor Anti-B Both Anti-A and Anti-B ABO Blood Types, cont. An antigen and an antibody of the same type react to clump RBC – so such combos must be avoided Type AB – universal recipients (lacks antibodies anti-A and anti-B) Type O – universal donors (lacks antigens A and B) However, the preferred donor is one with the matching blood type Rh Rh Blood Type is a separate antigen on Red blood cells – a person is either positive (they have the antigen) or negative (they do not have the antigen). It is inherited by a different set of genes that ABO blood type. It takes only 1 gene to be positive. A person with a + blood type can receive from both + and – people. A person with a – blood type can only receive from a – person. erythroblastosis fetalis erythroblastosis fetalis – When a mother is RH – and her baby is RH +. During their first pregnancy some blood is transferred from baby to mother. The mother then develops antibodies against RH+ blood. erythroblastosis fetalis Next pregnancy some of the blood from the mom gets in the baby and the antibodies cause the blood to agglutinate. Can cause fatality because of lack of oxygen (severe anemia) Treated by massive transfusions of Rh+ blood for the baby and removal of blood containing Rh+ antibodies. Need to include Hypotension Heart attack with causes or symptoms w statistics with coronary artery disease. Myocardial infarction Mitral valve prolapse leukemia Better explanation of erythroblastosis fetalis. Cordae tendanae & papillary muscles Review of cardiac muscle tissue.