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Harnessing the Semantic Web to Answer Scientific Questions: A Health Care and Life Sciences Interest Group demo Scientific Domain Focus • Use case focuses on Alzheimer’s Disease • AD is a devastating illness that impacts 26.6 million people worldwide • Prevalence is predicted to quadruple to 106.8 million by 2050 • An active Web community exists for AD research • Many different types of evidence need to be integrated Which Biological Processes occur in Dendrites? • Alzheimer’s disease is characterized by neural degeneration. Among other things, there is damage to dendrites and axons. • What resources do we have available to learn more about biological processes in dendrites? Scientific Data Sets • Integration and analysis of heterogeneous data sets • Hypothesis, Genome, Pathways, Molecular Properties, Disease, etc. PDSPki Gene Ontology NeuronDB Reactome BAMS Antibodies NC Annotations Entrez Gene Allen Brain Atlas BrainPharm MESH Mammalian Phenotype SWAN AlzGene PubChem Homologene Publications Technological Approach • Careful modeling that reflect biology to enable integration of data sources • All bio-entities were assigned URIs • Data translated to RDF/OWL and managed in a triple store • Using a reasoner to infer triples to increase expressiveness of queries • Query data with SPARQL and visualization tools Acknowledgements HCLS Demo Contributors HCLS Demo Contributors • John Barkley (NIST) • Susie Stephens (Eli Lilly) • Olivier Bodenreider (NLM, NIH) • Mike Travers ( • Bill Bug (Drexel University College of Medicine) • Gwen Wong (SWAN) • Huajun Chen (Zhejiang University) • Elizabeth Wu (SWAN) • Paolo Ciccarese (SWAN) • Kei Cheung (SenseLab, Yale) Data Providers • Tim Clark (SWAN) • Judith Blake (MGD.) • Don Doherty (Brainstage Research Inc.) • Mikail Bota (BAMS) • Kerstin Forsberg (AstraZeneca) • David Hill (MGD) • Ray Hookaway (HP) • Oliver Hoffman (CL) • Vipul Kashyap (Partners Healthcare) • Minna Lehvaslaiho (CL) • June Kinoshita (AlzForum) • Colin Knep (Alzforum) • Joanne Luciano (Harvard Medical School) • Maryanne Martone (CCDB) • Scott Marshall (University of Amsterdam) • Susan McClatchy (MGD) • Chris Mungall (NCBO) • Simon Twigger (RGD) • Eric Neumann (Teranode) • Allen Brain Institute • Eric Prud’hommeaux (W3C) • Jonathan Rees (Science Commons) • Alan Ruttenberg (Science Commons) • Matthias Samwald (Medical University of Vienna) Vendor Support • OpenLink - Kingsley Idehen, Ivan Mikhailov, Orri Erling, Mitko Iliev, Patrick van Kleef • HP - Ray Hookaway, Jeannine Crockford
