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Wildtype versus Mutant Ms. Alvarez [email protected] Arora Lab University of California Irvine Developmental and Cell Biology Department UC Irvine Dr. Kavita Arora Associate Professor J. Cho PhD Student QuickTime™ and a decompressor are needed to see this picture. QuickTime™ and a decompressor are needed to see this picture. M. Alvarez PhD Student What is the difference between these individuals? • Wolverine is a mutant and Ms. Alvarez is wild-type • Wild-type is the typical form • Mutants are organisms who’s DNA has been altered. These organisms display new characteristics or traits not found in wild-type. Mutations are permanent changes in the DNA sequence of a gene Why do scientist make mutant organisms? • The image “http://nfs.unipv.it/nfs/minf/dispense/immunol ogy/nunu_mouse2.jpg” cannot be displayed, because it contains errors. • To study the function/ role of the gene that has been mutated. Drosophila Melanogaster, a popular genetic model organism • ~ 50% of fly genes have vertebrate homologs • Small and easy to grow in lab • Short generation time • Produce high amounts of offspring QuickTime™ and a decompressor are needed to see this picture. Drosophila Melanogaster is used to study the biological processes underlying: • Embryonic development • Neurodegenerative disorders • Diabetes • Aging • Drug abuse • Cancer QuickTime™ and a decompressor are needed to see this picture. Myostatin Mutants Project goal: Identify the function of Myostatin in Drosophila Myostatin fly mutants die at pupa stage Acknowledgments • • • • • • • • Dr. Kavita Arora Jane Cho Tiffany Leung Nicole El-Ali Arora Lab Warrior Lab MSP Program NSF-GK-12 grant DGE-0638751