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ALCOHOL Chapter 8 PRODUCTION OF ALCOHOL Anaerobic condition Glucose Pyruvate Fermentation of yeast CO2 Acetaldehyde PRODUCTION OF ALCOHOL Acetaldehyde NADH NAD+ Ethanol ENERGY CONTENT OF COMMON ALCOHOLIC BEVERAGES Alcohol Metabolism DIGESTION AND ABSORPTION OF ALCOHOL No digestion required Absorbed by simple diffusion and moves directly into blood stream No specific mechanism required to enter body cells Alcohol damages cell membrane proteins as it enters body cells. ALCOHOL METABOLISM ALCOHOL METABOLISM ALCOHOL METABOLISM Catalase Found in the liver Minor pathway for alcohol metabolism Catalase H2O2 Ethanol H2 O Acetaldehyde What to do with Acetaldehyde? Acetaldehyde dehydrogenase Acetyl CoA is non-toxic to body cells Fate of Acetyl-CoA Acetyl-CoA CO2 + H2O Fatty Acid Glucose Moderate Alcohol Consumption Versus Alcohol Abuse Benefits and Problems Problems Associated with Alcohol Abuse Increases 5 of the top 10 causes of death in the U.S. Cirrhosis of the liver Inflammation of stomach and pancreas Hypertension and hemorrhagic stroke Problems Associated with Alcohol Abuse Brain damage and neurotransmitter imbalances Myocardial depression and Arrhythmias Cardiomyopathy Fetal Alcohol Syndrome
