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DRUGS By Tanya Ricketts A drug can be defined as a natural or synthetic substance that is used to produce physiological or psychological effects in humans or other higher order animals Why are drugs used? To sustain / prolong life Some misuse to escape from the pressures of life Others may use drugs to end life How many Americans drink alcohol regularly? 90 million 10 million are hopelessly addicted DOES IT CROSS SOCIAL/ETHNIC CLASSES OF SOCIETY? Yes TODAY 23 million people in the US are users of illicit drugs. Half – million heroin addicts and nearly 6 million users of cocaine FORENSICS LABS – More than 75% of evidence being evaluated in labs are drug related What’s the difference between PSYCHOLOGICAL DEPENDENCE and PHYSICAL DEPENDENCE Does drug use affect people’s needs : Example: HOW Social responsibilities Personal health Economic relationships Family obligations NARCOTIC DRUGS Narcotic – from Greek work narkotikos – Which implies lethargy or sluggishness Are analgesics They relieve pain by exerting a depressing action on the CNS What is the source of most analgesic narcotics? OPIUM Although Morphine is extracted from opium - most addicts prefer to use one of its derivatives – HEROIN Highly soluble in water What doest his matter? It’s easier to use by IV Provides high that lasts 3 – 4 hours – deep sense of well being, drowsiness Codeine is also present in opium Present in cough suppressants 1/6 as strong as morphine Not attractive street drug for addicts OxyContin – an analgesic narcotic that has effects similar to those of heroin – prescribed to a million patients for tx of chronic pain HALLUCINOGENS Are drugs that can cause marked alterations in normal thought processes, perceptions, and moods WHAT IS THE FIRST ONE THAT COMES TO MIND? Marijuana Most widely used illicit drug in the US More than 43 million Americans have tried First introduce into the US around 1920 Causes increased desire for sweets Long term use amotivational syndrome characterized by apathy, impairment of judgment, memory, and concentration Loss of interest in personal appearance And the pursuit of conventional goals WHAT TWO AREAS OF RESEARCH Involving marijuana Reduction of excessive eye pressure in glaucoma And lessening of nausea caused by powerful anticancer drugs OTHER HALLUCINOGENS LSD – lysergic acid diethylamide Vivid hallucinations up to 12 hours Changes in mood – laughing or crying Feeling of anxiety and tension Flashbacks and psychotic reactions even after DC use PCP Phencyclidine Cookbook methods May be mixed with other drugs Feelings of strength and invulnerability Dreamy sense of detachment Unresponsive, confused, and agitated Depression, irritability , feelings of isolation Audio/visual hallucinations Tendencies toward violence Suicide accompany long term daily use of the drug LSD lysergic acid dethylamide Visual hallucinations up to 12 hours Laughing to crying, mood changes DEPRESSANTS First one that comes to mind? ALCOHOL – ETHYL ALCOHOL Depressant action on the CNS Alcohol – to bloodstream – to brain – suppresses brain’s control of thought processes and muscle coordination WHAT DOES A DRUNK SOUND AND ACT LIKE? EXTREMELY HIGH DOSES – may cause and individual to lapse into unconsciousness or even into a comatose state that may be a prelude to a fatal depression of circulatory and respiratory functions BARBITURATES Downers They relax Feeling of well being, and produce sleep Slang – terms – barbs, yellow jackets, blue devils, reds Taken orally TRANQUILIZERS Relaxing tranquility without impairment of high thinking faculties or the inducement of sleep Major – reserpine and chlorpromazine – mental patients Mild – miltown, librium, valium, produce psychological and physical dependency GLUE SNIFFING Volatile solvents CNS depressants Toluene, naphtha, methyl ethyl ketone, gasoline, and trichloroethylene Feeling of exhilaration and euphoria combined with slurred speech, impaired judgment, and double vision, drowsiness, stupor May cause liver, heart, and brain damage High risk of death STIMULANTS Amphetamines Stimulate the CNS Uppers or speed Feeling of well being Increased alertness Followed by a decrease in fatigue and loss of appetite depression IV injection of amphetamine methamphetamine Flash or rush - followed by an intense feeling of pleasure constitutes the principal appeal of the in route speed freak Speed binge – may inject 500 - 1000 milligrams of amphetamines every 2 – 3 hours Users have euphoria that produces hyperactivity with a feeling of clarity of vision as well as hallucinations Then as it wears of - period of exhaustion and may sleep continuously for 1 – 2 days Then depression from days to weeks New smokable of meth – ice Effects for longer period of time Chronic users – exhibit violent destructive behavior and acute psychoses similar to paranoid schizophrenia COCAINE Powerful stimulant to the CNS Increased alertness and vigor Accompanied by the suppression of hunger, fatigue, and boredom Sniffed or snorted absorbed through the mucous membranes of the nose Crack – snorted – stimulates a pleasure center in the base of the brain, in an area connected to nerves that are responsible for emotions Cocaine related deaths are a result of cardiac arrest or seizures followed by respiratory arrest Peruvian farmers may be paid $200 for enough coca leaves to make one pound of cocaine. The refined cocaine will be worth $1,000 when it leaves Colombia and will sell at retail in the US for up to $20,000 CLUB DRUGS Synthetic drugs that are used at night clubs, bars, and raves ( all night dance parties) MDMA – Ecstasy GHB Rohypnol – Roofies Ketamine, methamphetamine CNS depressants Acts that are Associated with drug – sexual assault, rape, and robbery Effects accompanying the use of GHB include dizziness, sedation, HA, nausea Rohypnol – cant remember what happened during the hours after ingesting the drug Colorless, and tasteless Ecstasy – most popular drug at rave club scenes Mind altering Hallucinogenic and amphetamine – has effects like an appetite suppressant was later discovered to bring about feelings of happiness and relaxation Seizures, muscle breakdown, stroke, kidney failure, CV system failure often accompany chronic abuse of ecstasy ANABOLIC STEROIDS Synthetic compounds that are chemically related to the male sex hormone testosterone Promotes the dev. Of secondary male characteristics and accelerates muscle growth Male athletes given anabolic steroids has generally found little/marginal strength/performance Liver ca and other liver malfunctions have been linked to steroid use Masulinizing effects on females, infertility, and diminished sex drive in males Premature halting of bone growth Anger and destructive behavior depression DRUG – CONTROL LAWS Legal community requires a thorough knowledge of drug classification and definitions as they are delineated by drug laws Chemists report must contain all info that is needed to properly charge a suspect under the provisions of the existing law CONTROLLED SUBSTANCES ACT 5 schedules of classification Most severe penalties are associated with drugs that are listed in schedules I and II Example – I and II an first offense - up to 20 years in prison and fine of up to 1 million for individual or up to 5 million for other than individuals LOOK AT DIFFERENCE BT 252 - 253 READ 252 -254 The act reflects an effort to decrease the prevalence of clandestine drug laboratories designed to manufacture controlled substances Regulates the manufacture and distribution of precursors, the chemical compounds used by clandestine drug labs to synthesize drugs or abuse DRUG ID No room for error b/c its results will have a direct bearing on the process of determining the guilt or innocence of a defendant First – screening tests to reduce these possibilities to a small and manageable number - may by color tests – will produce ch. Colors for the more commonly encountered illicit drugs Second phase – the analysis must be devoted to pinpointing and confirming the drug’s identity COLOR TESTS Colors produced when brought into contact with specific chemical reagents Screening test only Microcystalline Tests More specific test Chemical reagent is added to a small quantity of the drug on a slide Chromatography Thin-layer and gas chromatography They separate drugs from their diluents while providing for their tentative id SPECTROPHOTOMETRY Selective absorption of light by drugs in the UV and IR regions of the electromagnetic spectrum provides a valuable technique UV spectrum not conclusive for the positive ID of a drug/ b/c other materials may very well produce an indistinguishable spectrum Establishes the probable identity of a drug Infrared spectrophotometry – specifically identify a substance Fingerprint of a compound MASS SPECTROMETRY Chromatography separates a drug from other substances - but not a specific id of material under investigation GC/MS – gas chromatography/mass spectrometry READ PAGE 259 ID OF MARIJUANA Botanical features observed under the microscope by a trained expert Chemical test Short hairs having the shape of bear claws of the upper side of the leaf PACKGING FOR EIVDENCE Glue sniffing – air tight Depends on the state the drug found as to how packaged Criminalistics chapter 9 Do forensics CD – Activity 8 drug bust