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VIRUN
®
How to be a wizard
By: Philip Bromley
CEO, VIRUN, Inc.
Cal Poly Pomona, Biotechnology
How to be a Wizard…
• Creativity and Invention
• Entrepreneurship Gives us Freedom to Invent &
Capitalize on our Invention
• Entrepreneurship through invention and “The
Business”
• VIRUN – proof of concept
Unlike Gandolph-the-Great or Merlin, most of us have to work at
being a wizard…
…once you are able to harness the magic of
science and the wizardry of innovation, nothing
can stop you from success.
Creativity and innovation through science
stem from multiple factors:
A. Academic, University and our Professors/teachers
a. You can not invent something without learning the fundamentals
B. Research and Development
b. There is a reason “Re” is a prefix for the word “Research,” we learn from
trial and error and research is the key fundamental.
C. Science is learned but is also an art
c. How do you learn to invent something if it has not yet been invented?
Albert Einstein
said:
“if the facts don’t
fit the theory,
then change the
theory”
Music
Science
Literature
Art
Math
Understanding that not everything
can be solved by a mathematical
equation is important when doing
research and development. IT’s
STILL NECESSARY, but nonetheless
important to understand that
sometimes science cannot be
explained by means of 2 + 2 =4,
sometimes 2 + 2 = 5. This is when
creativity becomes our asset.
Instances where creativity
becomes necessary, we have to
rely on intuition or trial and error.
Sometimes we have to see what is
not there.
Creativity can be influenced by
many things: Unique experiences,
being different, art and music all
play a role in broadening our
creative thinking.
The art of science….
Rose
Rose Petal
Rose Petal Under
Stereo Microscope
Innovation-killer is looking at everything for what it is and
not what it could be or what is beyond the obvious….
Prediction based on science and mathfundamentals combined with the art-of-science
enable beauty to reveal itself which then can
lead to invention
When Creativity Becomes Our Asset…
…Entrepreneuriship is Born
Steps to Success
⌠⌡ entrepreneurship
⌠⌡ invent
⌠⌡ r & d
⌠⌡ learn
Me
• San Diego State University 1997 - 2001
• General Chemistry
• R&D in the Pharmaceutical Industry
– Liposomal encapsulation, viral transvection,
protien ligand augmentation
• Co-founded VIRUN in 2003
VIRUN
Established 2003
Biotechnology company in the areas of drug delivery and
food-beverage technology.
35 employees
45 patents and patents pending world-wide
VIRUN is an acronym for virus-immune
o 2003, VIRUN formed as a drug delivery biotech company.
o 2004, VIRUN patented the first oral anti-viral patent using
Tf (Transferrins) linked to proteins and naïve compounds MAPD
(Mucosal Adhesive penetrating drugs).
•
Highest oral bioavailability of human insulin compared to i.v. injection
o 2005, VIRUN develops nanotechnology utilizing novel Diester Tocopherol/yl
bound Succinic Acid Polymers (DPtechnology – direct precision).
•
•
Produce on average 5-35nm particle size micelles based on dilution.
Increased oral bioavailability, however Tocopheryl Polyethylene Glycol Succinate
(TPGS) does not absorb into blood plasma so shelved project.
o 2007, VIRUN develops nanotechnology for food, beverages and supplements.
•
•
Food-beverage Industry demanded encapsulation technology that does not
absorb into blood plasma such as Polysorbates - revived DPtechnology using
Tocopherol/yl Polymer (TPGS).
Generally Recognized as Safe (GRAS) determination with the FDA. European Food
Safety Authority (EFSA) opinion from Europe. EFSA concludes TPGS from polymer
does not significantly absorb into blood plasma thereby creating a new, safe and
clean label claim encapsulation technology for food.
MAPD Patent numbers 8,414,914 8,252,323 & 7,906,140
Transferrin (Transfers Fe)
o VIRUN’s MAPD binds iron loaded
transferrin (Holo-Tf) to drugs that
have poor oral bioavailability.
o The Tf-drug binds to Lipo Receptor
Proteins (LRP’s) outside the gut cell
membrane and then transverses
the cell into the lymphatics
delivering the drug into blood
plasma.
o Lactotransferrin is used for oral
delivery and Serum Transferrin is
used for further cell targeting
within blood plasma, such as
targeting tumor sites or crossing
the blood brain barrier (BBB).
Nature designed it….
….we followed it….
Your body converts Omega-3
EPA and DHA as well as other
non polar compounds into
micelles so they can absorb Improving BIOAVAILABILITY
…micelles in the range of 10 – 20nm can pass
through the brush boarder membranes of your gut
mucosa increasing the oral bioavailability of non
polar compounds compared to the non polar
compound itself. Therefore, encapsulating into
micelles prior to ingestion can improve the oral
bioavailability of non polar compounds.
o Micelles are composed of a single lipid
monolayer comprised of a surfactant, such as
Vitamin E Succinate Diester, and water….
o VIRUN utilizes natural micelles to encapsulate
non polar (fat soluble) compounds within the
micelle layer.
o The outer shell of the micelle is polar leaving the
inner layer non polar. This allows the micelle
carrying the non polar (fat soluble) compound ,
such as omega-3 EPA DHA oil, to dissolve clear
into water with reduced particle size
A surfactant, in short, is an
amphiphillic molecule that is both
Polar (fat insoluble) and non-polar
(fat soluble). Encapsulating a fat
soluble compound inside the micelle
allows it to dissolve into water. In
some instances, clear
10nm particle size
nanotechnology
1micron particle size
VIRUN encapsulates non polar (fat
soluble) compounds, Omega-3 EPA
DHA, CoQ10, Vitamins A, D and E
to be better absorbed in the body
and also be stable in food and
beverage applications.
Also, using naturally derived
Vitamin E as the emulsifier, we
can add natural flavors and
colors, such as encapsulating
Curcumin (orange color), Beta
Carotene (red color) and
other non polar (fat soluble)
compounds into foods and
beverages.
VIRUN
®
How to be a wizard
By: Philip Bromley
CEO, VIRUN, Inc.
Cal Poly Pomona, Biotechnology