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NUTRITIONAL STATUS IN ADOLESCENTS WITH EPILEPSY Presented by V.SWAPNA Co-authors: Drs. K.A. Parvathy, C.V.Harinarayan, B. Vengamma, Bindu Menon, U.V. Prasad,G. Hima Bindu AIM To evaluate The anthropometric measurements Dietary parameters and Biochemical Metabolism markers of Bone Mineral NEED FOR THE STUDY Adolescence, a period of transition, occupies a crucial position in the life of human beings. Under-nutrition reduces growth rate, learning and working capacity amongst adolescents. Epilepsy is the most serious common neurological disorder. Epilepsy treatment leads to nutritional deficiencies, especially vitamin D3 Metabolism. AED INTERFER WITH 25 OHase AT THE LIVER AND LOWERS THE FORAMTION OF1,25(OH)2 D3. Low 25(OH)D levels leads to low 1,25(OHD)D levels. Hence the absorption of calcium from the gut is retarded. MATERIALS AND METHODS n= 64 Anthropometry Ht, Wt, BMI, Arm span, U.S, L.S Skin fold thickness – Triceps, Biceps, S.Scapular, Suprailliac. Dietary Intake – Calories, protein, fat, Ca, Phos, Phy/Ca ratio Biochemical parameters – Serum Albumin, Ca, Phos, SAP, Creatinine, 25(OH)D, ntact PTH. STATISTICAL ANALYSIS The results presented as Mean ± SD Correlation co-efficient (Pearson's) - Value P<0.05 taken as significant. Statistical package used SPSS software (version 10.0). DIETARY INTAKE PER DAY NUTRIENTS MEAN ± SD Energy(K.cal) 2059±150 D.Calcium(mg) 297±33 D.Phosphorous(mg) 574±84 D.Protein(gm) 36±7 D.Fat(gm) 18±2 Phy/Cal 0.6±0.08 BIOCHEMICAL VALUES PARAMETERS MEAN ± SD S.Albumin (3.0-5.5gm/dl) 4±0.34 S.Calcium (8-10.5mg/dl) 10±0. S.Phoshorous(2.7-4.5 mg/dl) 4±0.8 SAP (140 IU/l) 95±59 S.Creatinine (<1.6 mg/dl) 0.79±0.19 25(OH)D (>20 ng/ml) 16.59±10.4 PTH (13-54pg/ml) 21.57±11.3 Distribution of Vit D levels in the Study Sample 20% 35% <10ng/ml 10-20ng/ml >20ng/ml 45% Duration of Drugs used by study samples 7% <5y 36% 5-10y 57% >10y Percent of sample using each Drug 70% 60% 64% 50% 50% 43% 40% 30% 20% 10% 0% % of Pop Phy CBZ PB *SINCE TREATMENT INCLUDES MORE THAN ONE DRUG, THE PERCENTAGE WILL EXCEED HUNDRED. DISCUSSION AED’s can lower the uptake of calcium, worsening the bone health. Inadequate intake of calcium can lead to a decreased amount of bone calcium reserves. Adolescent epileptic girls in the rural areas could be greater risk of nutritional stress. LIMITATIONS OF THE STUDY The socio-economic aspects have not been dealt Micro study The data was collected from only SVIMS, Tirupati. Data from other hospitals and clinics were not collected. The epilepsy patients approaching SVIMS for treatment mostly belong to lower socioeconomic strata. Strategies Awareness Dietary Intake Supplements Life Skills Education Primary Care Social Stigma CONCLUSION Hypo Vitaminosis-D and low dietary calcium intake adversely affect the bone mineral homeostasis in adolescents with epilepsy. There is a need to treat epilepsy through proper diet & nutrition and reducing the intake of medicines over a period of time CONCLUSION Epileptic adolescents to be supplemented with dietary calcium and vitamin-D Health educators have to be trained to deal with adolescent girls with epilepsy as they are vulnerable for social evils like early marriage Than Q