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NUTRITIONAL STATUS IN
ADOLESCENTS WITH EPILEPSY
Presented
by
V.SWAPNA
Co-authors:
Drs. K.A. Parvathy, C.V.Harinarayan, B. Vengamma, Bindu Menon,
U.V. Prasad,G. Hima Bindu
AIM
To evaluate
 The anthropometric measurements
 Dietary
parameters and
 Biochemical
Metabolism
markers of Bone Mineral
NEED FOR THE STUDY

Adolescence, a period of transition, occupies
a crucial position in the life of human beings.
 Under-nutrition reduces growth rate, learning
and working capacity amongst adolescents.

Epilepsy is the most serious common
neurological disorder.
 Epilepsy treatment leads to nutritional
deficiencies, especially vitamin D3
Metabolism.
 AED INTERFER WITH 25 OHase
AT THE LIVER AND LOWERS THE
FORAMTION OF1,25(OH)2 D3.
Low 25(OH)D levels leads to low
1,25(OHD)D levels.
Hence the absorption of calcium
from the gut is retarded.
MATERIALS AND METHODS





n= 64
Anthropometry  Ht, Wt, BMI, Arm span, U.S, L.S
Skin fold thickness –
 Triceps, Biceps, S.Scapular, Suprailliac.
Dietary Intake –
 Calories, protein, fat, Ca, Phos, Phy/Ca ratio
Biochemical parameters –
 Serum Albumin, Ca, Phos, SAP, Creatinine,
25(OH)D, ntact PTH.
STATISTICAL ANALYSIS

The results presented as Mean ± SD

Correlation co-efficient (Pearson's) - Value
P<0.05 taken as significant.

Statistical package used SPSS software
(version 10.0).
DIETARY INTAKE PER DAY
NUTRIENTS
MEAN ± SD
Energy(K.cal)
2059±150
D.Calcium(mg)
297±33
D.Phosphorous(mg)
574±84
D.Protein(gm)
36±7
D.Fat(gm)
18±2
Phy/Cal
0.6±0.08
BIOCHEMICAL VALUES
PARAMETERS
MEAN ± SD
S.Albumin (3.0-5.5gm/dl)
4±0.34
S.Calcium (8-10.5mg/dl)
10±0.
S.Phoshorous(2.7-4.5 mg/dl) 4±0.8
SAP (140 IU/l)
95±59
S.Creatinine (<1.6 mg/dl)
0.79±0.19
25(OH)D (>20 ng/ml)
16.59±10.4
PTH (13-54pg/ml)
21.57±11.3
Distribution of Vit D levels in the Study
Sample
20%
35%
<10ng/ml
10-20ng/ml
>20ng/ml
45%
Duration of Drugs used by study
samples
7%
<5y
36%
5-10y
57%
>10y
Percent of sample using each Drug
70%
60%
64%
50%
50%
43%
40%
30%
20%
10%
0%
% of Pop
Phy
CBZ
PB
*SINCE TREATMENT INCLUDES MORE THAN ONE DRUG, THE
PERCENTAGE WILL EXCEED HUNDRED.
DISCUSSION
 AED’s
can lower the uptake of calcium,
worsening the bone health.
 Inadequate
intake of calcium can lead to a
decreased amount of bone calcium
reserves.
 Adolescent
epileptic girls in the rural areas
could be greater risk of nutritional stress.
LIMITATIONS OF THE STUDY
 The
socio-economic aspects have not
been dealt
Micro study
 The data was collected from only SVIMS,
Tirupati.
 Data from other hospitals and clinics were
not collected.
 The epilepsy patients approaching SVIMS
for treatment mostly belong to lower socioeconomic strata.
Strategies
 Awareness
 Dietary
Intake
 Supplements
 Life Skills Education
 Primary Care
 Social Stigma
CONCLUSION
 Hypo
Vitaminosis-D and low dietary calcium
intake adversely affect the bone mineral
homeostasis in adolescents with epilepsy.
 There
is a need to treat epilepsy through
proper diet & nutrition and reducing the
intake of medicines over a period of time
CONCLUSION
 Epileptic
adolescents to be supplemented
with dietary calcium and vitamin-D
 Health
educators have to be trained to deal
with adolescent girls with epilepsy as they
are vulnerable for social evils like early
marriage
Than Q