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Cardiovascular System Notes: The Heart Interesting Cardiovascular System Facts The human heart creates enough pressure to squirt blood 30 feet. NOTES – THE HEART • Location: • cavity between the lungs, 2/3 left of midsagittal • roughly the size of a fist Figure 18.2b Location of the heart in the mediastinum. Mediastinum Heart Left lung Body of T7 vertebra Posterior © 2013 Pearson Education, Inc. Figure 18.2c Location of the heart in the mediastinum. Superior vena cava Pulmonary trunk Aorta Parietal pleura (cut) Left lung Pericardium (cut) Apex of heart Diaphragm © 2013 Pearson Education, Inc. • Heart Anatomy • PERICARDIUM • outer membrane of the heart • 2 layers 1. Parietal pericardium: external (outer) layer 2. Visceral pericardium (epicardium): part of the heart wall • Functions: • protection – physical barrier • anchors heart to other structures • provides lubrication to reduce friction – allows the heart to beat easily • THE HEART WALL • 3 layers 1. Epicardium: outer portion (visceral pericardium) EPICARDIUM 2. Myocardium: middle layer consists of twisted cardiac muscle MYOCARDIUM • THIS IS THE LAYER THAT ACTUALLY CONTRACTS 3. Endocardium: inner layer made of epithelial tissue ENDOCARDIUM Figure 18.3 The pericardial layers and layers of the heart wall. Pulmonary trunk Fibrous pericardium Pericardium Parietal layer of serous pericardium Myocardium Pericardial cavity Epicardium (visceral layer of serous pericardium) Myocardium Endocardium Heart chamber © 2013 Pearson Education, Inc. Heart wall Homeostatic Imbalance • Pericarditis – Inflammation of pericardium – Roughens membrane surfaces pericardial friction rub (creaking sound) heard with stethoscope – Cardiac tamponade • Excess fluid sometimes compresses heart limited pumping ability © 2013 Pearson Education, Inc. The Pulmonary and Systemic Circuits • Receiving chambers of heart: – Right atrium • Receives blood returning from systemic circuit – Left atrium • Receives blood returning from pulmonary circuit © 2013 Pearson Education, Inc. The Pulmonary and Systemic Circuits • Pumping chambers of heart: – Right ventricle • Pumps blood through pulmonary circuit – Left ventricle • Pumps blood through systemic circuit © 2013 Pearson Education, Inc. Figure 18.1 The systemic and pulmonary circuits. Capillary beds of lungs where gas exchange occurs Pulmonary Circuit Pulmonary arteries Aorta and branches Venae cavae Right atrium Right ventricle Oxygen-rich, CO2-poor blood Oxygen-poor, CO2-rich blood © 2013 Pearson Education, Inc. Pulmonary veins Left atrium Heart Left ventricle Systemic Circuit Capillary beds of all body tissues where gas exchange occurs Figure 18.4 The circular and spiral arrangement of cardiac muscle bundles in the myocardium of the heart. Cardiac muscle bundles © 2013 Pearson Education, Inc. • HEART CHAMBERS • 4 chambers • Atrium (left/right atria) • divided by the INTERATRIAL SEPTUM • Function of Atria: receives blood from veins (pig heart) • RIGHT ATRIA • receives blood from superior & inferior vena cava • blood that’s been used • oxygen poor – high in CO2 • LEFT ATRIA • receives blood from pulmonary veins • coming from lungs • rich in oxygen • Ventricles (left/right) (pig heart) • muscular pumps – divided by INTERVENTRICULAR SEPTUM • RIGHT VENTRICLE • receives blood from the right atria (O 2 poor) • pumps blood to the lungs through the PULMONARY ARTERIES • LEFT VENTRICLE • receives blood (O2 rich) from the left atrium • pumps blood to the body through the AORTA Figure 18.10 Anatomical differences between the right and left ventricles. Left ventricle Right ventricle Interventricular septum © 2013 Pearson Education, Inc. • Systemic Circulation • heart – lungs – heart – body – heart • HEART VALVES (4) • allow for “one way” circulation • 2 Atrioventricular Valves (AV valves) 1. Tricuspid Valve: between right atria and right ventricle 2. Bicuspid or Mitral Valve: between left atria and left ventricle • heavier & stronger of the two Figure 18.6a Heart valves. Pulmonary valve Aortic valve Area of cutaway Mitral valve Tricuspid valve Myocardium Mitral (left atrioventricular) valve Tricuspid (right atrioventricular) valve Aortic valve Pulmonary valve Cardiac skeleton © 2013 Pearson Education, Inc. Anterior Figure 18.6b Heart valves. Pulmonary valve Aortic valve Area of cutaway Mitral valve Tricuspid valve Myocardium Mitral (left atrioventricular) valve Tricuspid (right atrioventricular) valve Aortic valve Pulmonary valve © 2013 Pearson Education, Inc. Figure 18.6c Heart valves. Pulmonary valve Aortic valve Area of cutaway Mitral valve Tricuspid valve Chordae tendineae attached to tricuspid valve flap © 2013 Pearson Education, Inc. Papillary muscle Figure 18.6d Heart valves. Pulmonary valve Aortic valve Area of cutaway Mitral valve Tricuspid valve Opening of inferior vena cava Tricuspid valve Mitral valve Chordae tendineae Myocardium of right ventricle Interventricular septum Papillary muscles © 2013 Pearson Education, Inc. Myocardium of left ventricle • CHORDAE TENDINAE and papillary muscles stop valves from being folded backwards CHORDAE TENDINAE 3. Pulmonary Semilunar Valve: between the pulmonary artery and right ventricle 4. Aortic Semilunar Valve: between aorta and left ventricle Animation Please note that due to differing operating systems, some animations will not appear until the presentation is viewed in Presentation Mode (Slide Show view). You may see blank slides in the “Normal” or “Slide Sorter” views. All animations will appear after viewing in Presentation Mode and playing each animation. Most animations will require the latest version of the Flash Player, which is available at http://get.adobe.com/flashplayer. Homeostatic Imbalance • Two conditions severely weaken heart: – Incompetent valve • Blood backflows so heart repumps same blood over and over – Valvular stenosis • Stiff flaps – constrict opening heart must exert more force to pump blood • Valve replaced with mechanical, animal, or cadaver valve © 2013 Pearson Education, Inc. Pathway of Blood Through the Heart • Pulmonary circuit – Right atrium tricuspid valve right ventricle – Right ventricle pulmonary semilunar valve pulmonary trunk pulmonary arteries lungs – Lungs pulmonary veins left atrium © 2013 Pearson Education, Inc. Pathway of Blood Through the Heart • Systemic circuit – Left atrium mitral valve left ventricle – Left ventricle aortic semilunar valve aorta – Aorta systemic circulation PLAY Animation: Rotatable heart (sectioned) © 2013 Pearson Education, Inc. Coronary Circulation • Functional blood supply to heart muscle itself – Delivered when heart relaxed – Left ventricle receives most blood supply • Arterial supply varies among individuals • Contains many anastomoses (junctions) – Provide additional routes for blood delivery – Cannot compensate for coronary artery occlusion © 2013 Pearson Education, Inc. Coronary Circulation: Arteries • Arteries arise from base of aorta • Left coronary artery branches anterior interventricular artery and circumflex artery – Supplies interventricular septum, anterior ventricular walls, left atrium, and posterior wall of left ventricle • Right coronary artery branches right marginal artery and posterior interventricular artery – Supplies right atrium and most of right ventricle © 2013 Pearson Education, Inc. Figure 18.11a Coronary circulation. Aorta Pulmonary trunk Left atrium Superior vena cava Anastomosis (junction of vessels) Left coronary artery Right atrium Right coronary artery Right ventricle Right marginal artery Circumflex artery Posterior interventricular artery The major coronary arteries © 2013 Pearson Education, Inc. Left ventricle Anterior interventricular artery Homeostatic Imbalances • Angina pectoris – Thoracic pain caused by fleeting deficiency in blood delivery to myocardium – Cells weakened • Myocardial infarction (heart attack) – Prolonged coronary blockage – Areas of cell death repaired with noncontractile scar tissue © 2013 Pearson Education, Inc. Microscopic Anatomy of Cardiac Muscle • Cardiac muscle cells striated, short, branched, fat, interconnected, 1 (perhaps 2) central nuclei • Connective tissue matrix (endomysium) connects to cardiac skeleton – Contains numerous capillaries • T tubules wide, less numerous; SR simpler than in skeletal muscle • Numerous large mitochondria (25–35% of cell volume) © 2013 Pearson Education, Inc. Figure 18.12a Microscopic anatomy of cardiac muscle. Nucleus Intercalated discs © 2013 Pearson Education, Inc. Cardiac muscle cell Gap junctions Desmosomes Microscopic Anatomy of Cardiac Muscle • Intercalated discs - junctions between cells - anchor cardiac cells – Desmosomes prevent cells from separating during contraction – Gap junctions allow ions to pass from cell to cell; electrically couple adjacent cells • Allows heart to be functional syncytium – Behaves as single coordinated unit © 2013 Pearson Education, Inc.