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Download PowerPoint Presentation - Cell Architecture: The Microtubule
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Organizing the cell: the Cytoskeleton Intermediate Filaments Microfilaments Microtubules M i c r o t u b u l e s QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. Text and image sources are included using the notes function of this file EM views QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. FtsZ: a prokaryotic ur-tubulin? QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. The Tubulin Superfamily alpha Part of heterodimer All Eukaryotes beta Part of heterodimer All Eukaryotes gamma Part of microtubule initiation complex All Eukaryotes delta Centriolar component (c-tubule) Various epsilon Localized to centriole in a cell-cycle specific manner Various eta Basal body component Paramecium zeta Basal body component Trypanosomes FtsZ Component of filaments Prokaryotes Microtubule model exchangeable GDP GTP “Minus” end “Plus” end QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. GTP GDP GDP GDP GDP GDP GDP GDP GDP GTP GTP GTP GTP GTP GTP GTP GTP GTP GTP GTP GTP GTP GTP GTP Beta-tubulin “cap” GTP Plus In Tubulin dimer atomic structure Out Minus Microtubule fly-by QuickTime™ and a Sorenson Video 3 decompressor are needed to see this picture. Narrated Video Microtubule initiation MTOCs QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. The Centrosome revealed 9-triplet microtubule centrioles pericentriolar material singlet microtubules Washout of nocodazole 10 um QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. Successive images at 2 minute intervals after changing to drug-free media (at timepoint A) Dynamic Instability in vitro QuickTime™ and a Video decompressor are needed to see this picture. Video Dynamic instability in vivo Video QuickTime™ and a MPEG-4 Video decompressor are needed to see this picture. QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. Video Fluorescence Speckle Microscopy QuickTime™ and a Video decompressor are needed to see this picture. QuickTi me™ and a TIFF (U ncompressed) decompressor are needed to see this picture. Stathmin microtubulebinding domain Disassembly Video In vitro assembly on axonemal microtubule seeds +/- Stathmin Activity QuickTime™ and a Sorenson Video 3 decompressor are needed to see this picture. Katanin QuickTime™ and a Animation decompressor are needed to see this picture. Video Microtubule wall (Mitotic Extract) (Interphase Extract) Centrosomal release QuickTime™ and a Cinepak decompressor are needed to see this picture. Treadmilling QuickTime™ and a Cinepak decompressor are needed to see this picture. Speckles Photobleaching MAPs Note the crossbridges (arrows) between microtubules QuickTime™ and a TIFF (Uncomp resse d) de co mpres sor a re ne eded to see this picture . Plus end tracking proteins (+TIPS) Video Video QuickTime™ and a Video decompressor are needed to see this picture. um GFP::EB1 Cy3 Tubulin Interrelationship between microtubules and microfilaments Video Microtubule effects Microfilament effects QuickTime™ and a Video decompressor are needed to see this picture. QuickTime™ and a Video decompressor are needed to see this picture. Video Synthesis and Folding Signal transduction stathmin cof B cof C abGTP CCT b Rac Integration with actin networks Cdc42 cof E a PAK cof D GEF? cof A Rho abGDP Tub; CLIP-170, EB-1 mDia Dynamic Polymer stathmin catastrophic kinesins katanin severin (EF1a) Pathways Rho IQGAP stabilizing MAPs; + end capture Stable Polymer Assembly/Disassembly
