Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Accelerating AIDS Vaccine Discovery Through the Use of a Collaborative Web-based Information System QuickTime™ and a decompressor are needed to see this picture. Aaron J. Wilson1, David Mark1, David O’Connor2, Mark Igra3, Jess Garms3, Adrian McDernott1 1International 2University AIDS Vaccine Initiative, New York, NY 3Labkey Software, Seattle, WA of Wisconsin, Madison, WI Quick Time™ and a decompressor are needed to s ee this pic ture. Consortia Based Science Developments The field of HIV research has experienced a recent emergence of consortia based science as evidenced by the groups CHAVI, CAVD, and IAVI’s AIDS Vaccine Consortium. These investigational groups are engaged in collaborations that are creating datasets of ever increasing size and complexity. There is now an acute need for a laboratory system that can provide information centralization, higher throughput data analysis and expanded cross study data mining capabilities. Early usability testing of the system quickly revealed the need to address the implicit heterogeneities found in disparate data types. The result is a novel user interface displayed as a chronological map. The map allows users of variable skill and investment to intuitively visualize and interact with temporally indexed datasets within a study. In conjunction the development employs powerful statistical output schemas that display interim results in real time. Crucial study decisions can be rapidly informed thereby accelerating the translation of the most promising vaccine concepts into candidates that are ready for clinical testing. QuickTime™ and a decompressor are needed to see this picture. QuickTime™ and a decompressor are needed to see this picture. QuickTime™ and a decompressor are needed to see this picture. Figure 1. IAVI sponsored AVC network QuickTime™ and a decompressor are needed to see this picture. Figure 2. Trucount assay Knowledge Sharing In recognition of the gaps in data centralization for consortia IAVI is supporting the development of LabKey Softwares’s open source, webbased software to provide a more expansive solution to capturing and reporting data from across disparate studies. Understanding common concerns regarding centralized data repositories the system is specially designed to: allow the importation and analysis of diverse study datasets, and most importantly protect publication rights and intellectual property. Figure 3. Interactive temporal map Figure 4. Statistical output in realtime Future Directions IAVI’s ultimate goal is to accelerate study interpretation across the entire AIDS vaccine discovery field. In order to accomplish this intuitive metaanalysis tools and techniques are being designed to allow studies to be mined with unprecedented resolution. QuickTime™ and a decompressor are needed to see this picture. Acknowledgments QuickTime™ and a decompressor are needed to see this picture. IAVI would like to thank the generosity and of the many donors that make this work possible. QuickTime™ and a decompressor are needed to see this picture. References Labkey Software Foundation: www.Labkey.org Shulman et.al, Cytometry A. 2008 Sep;73(9):847-56 Figure 2. Data submission UI Figure 3. Web accessible flow data