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COLOSTRUM 101 An Overview of Nature’s Amazing Immune-Enhancing & Anti-Aging Superfood About Sequence Health A niche company dedicated to ethical & superior colostrum The only genuine 6 hour first milking colostrum supplier in Canada Science team: Dr. Richard Cockrum, Dr. Beth Ley & Dr. Jonn Randel (Canada) & Dr. Sherif Sabry (Egypt) Aggressive advertising, high quality educational/promotional tools and strong retail support Dr. Richard Cockrum Dr. Beth Ley What is Colostrum? Colostrum is the pre-milk fluid produced by female mammals prior to birth Naturally rich in immune and growth factors, it is life’s first food and can benefit people of all ages Long history of use in Ayurvedic & Western medicine Bovine colostrum is almost identical to human colostrum; it is not species specific and can benefit all mammals Dairy cows produce more than enough colostrum to supply human needs without depriving calves of their essential first food Why We Need Colostrum New strains of bacteria and viruses found resistant to existing antibiotics and drugs Ever-increasing levels of chemical pollutants in our food, water and air resulting in compromised immune systems Overwhelmed immune systems due to job, family and environmental stresses Impaired tissue & muscle repair due to pushing the body beyond its natural limits As we age, our bodies produce less and less of the immune and growth factors essential for optimal health and vitality What’s in Colostrum? Bovine colostrum contains many essential nutrients and bioactive components, identical to those found in milk but at higher concentrations. These include mainly: Immunoglobulins (Igs): mainly IgA, IgG & IgM Lactoperoxidase (Lp): anti bacterial enzyme Lysozyme (Lys): anti-infective, gentle oral germicide Lactoferrin (Lf): anti-infective, antioxidant, iron transporter a-Lactalbumin (a-Lac): tryptophan provider Growth factors Cytokines, nucleosides, vitamins, peptides and oligosaccharides Benefits of Colostrum Boosts natural resistance to illness/disease and helps fight off bacterial and viral infection Protects against auto-immune disorders Improves state of chronic health problems Builds lean muscle mass and burns fat Increases energy and improves memory and mood Supports cellular growth and repair to slow down the aging process IgG IgG of bovine colostrum prevent, in humans, villous atrophy and stimulates mucosal healing of patient suffering from inflammatory gut diseases They reduce diarrhea symptoms in infants and protect intestinal mucosa from pathogen bacteria adhesion. IgGs attacks bacteria and parasites entering the gut; as IgG has two antigen binding sites, it recognizes, binds and destroys antigen by coating the microbe before destruction by the macrophage. As the attack is located in the digestive tract, the immune system is not concerned providing from any immune reaction. Growth Factors Growth factors are proteins that play an important role in the regulation of cell division and tissue proliferation. By binding to receptors on the cell surface, they activate (or inhibit) cellular proliferation and(or) differentiation. They are secreted by all kind of tissue and comprise a lot of different molecules as cytokines, chemokines, interleukines,… Growth factors such as IGF-1 and IGF2, TGFA and TGF-B are present in bovine colostrum. Supplementing Human Growth Factors (HGH) is supposed to slow the aging process. A successful HGH supplementation requires the preparation of the body for the increased presence of this substance. The selected ingredients in this unique formula could address the health of four major areas: •The brain •The nervous system •The energy systems (Adrenals and cellular ATP) •The body's drainage system PRPs PRP (ProlineRich Polypeptides) is also known as colostrinin, colostrinine, transfer factor, and other names, but they are all essentially the same fraction of colostrum. Actually a group of related polypeptides, PRPs from colostrum have demonstrated remarkable immunologic and neurologic properties. PRPs immunological function relate to their ability to modulate and stabilize many biological processes in the body including cytokine and immune activity Pro-rich antimicrobial peptides are a group of linear peptides of innate immunity isolated from mammals and invertebrates, and characterized by a high content of proline residues (up to 50%). Members of this group are predominantly active against Gramnegative bacterial species which they kill by a non-lytic mechanism, at variance with the majority of the known antimicrobial peptides. Importance of First Milking Birth is the event that stops the production of colostrum and starts the production of milk The sooner after birth colostrum is collected, the higher its levels of beneficial immune and growth factors Only first milking colostrum is used in scientific research studies as colostrum quality declines rapidly after birth Importance of First Milking 15% % Protein Colostrum collected just 24 hours after birth contains less than one quarter of the immune and growth factors present at birth 20% 10% 5% 0% 0 3 6 12 24 Hours after birth Importance of Oral Delivery Most pathogens enter body orally Our oral cavity’s mucosal membranes are loaded with immuno-receptor sites Absorption in oral cavity triggers entire body’s immune system response Greatest benefits observed in scientific studies achieved via oral delivery North America Category Overview Total category size in US is about 30 million; in Canada, approx 1 million but growing. Category experienced extremely rapid growth since introduction in 1996 but has slowed in past years due to lack of awareness, education & promotion Significant coverage in 2 best-selling books, “Bio-Age” (Brad King) and “The Food Connection” (Sam Graci) can help increase demand Colostrum recently getting some new momentum in mainstream media in North America. Sequence Colostrum Products Lozenges: Convenient, tasty, featuring slow mucosal delivery for maximum absorption; our best seller. Powder: Pure, potent and versatile; can be taken orally or applied topically. Capsules: Same as powder but in more convenient dosage form Overcoming Objections Does the Colostrum raw material come from 3rd world? Sequel colostrum comes from the finest certified Grade A dairies from the midwest North America Colostrum is sourced from hundreds of small, family run farms with herds of typically less than 50 cows All cows are pastured and supplementally fed a diet of grains,legumes, vitamins and minerals No growth or milk production hormones are ever given to pregnant cows as it would cause them to abort All colostrum batches are tested and certified to be free of bacteria, heavy metals, nitrates and nitrites and pesticides Ask to see a certificate of analysis Overcoming Objections Isn’t colostrum just for babies? Colostrum has been used for thousands of years in Ayuverdic medicine for people of all ages In Western medicine, there are volumes of research studies proving the benefits of colostrum for people of all ages As we age, our bodies gradually produce less of the immune & growth factors that help fight disease, repair body tissue and promote energy and vitality. Colostrum is the only natural source of these lifesupporting immune & growth factors! Overcoming Objections Colostrum is too expensive… Colostrum is a proactive approach to healthy immunity and longevity Consider the costs of illness and disease Colostrum can make other supplements and medications more effective or even obsolete Just $0.78 a day does the job for most people What is your long term health worth?