Download the use of dialyzable bovine colostrum extract

THE USE OF DIALYZABLE BOVINE COLOSTRUM EXTRACT IN
CONJUNCTION WITH A HOLISTIC TREATMENT MODEL FOR NATURAL
KILLER CELL
STIMULATION IN CHRONIC ILLNESS
Solstice Clinical Associates, Tucson, Arizona, July, 1998
Abstract
A longitudinal evaluation of the natural killer cell (NK activity) of peripheral blood
lymphocytes was performed in 107 patients with documented and advanced
Chronic Illness and followed for an average period of 13.2 months. At the time of
primary evaluation and treatment, the absolute value of natural killer cell activity
was significantly lower than the normal range. Hence, the association of chronic
illness with the syndrome of low natural killer cell activity.
During the follow-up period, a variety of nutritional agents were given to support
natural killer cell function and then dialyzable bovine colostrum extract was added
to the protocol. In the ensuing months, the curve of NK cell reactivation into normal
ranges and above was monitored as immune system competence was restored.
The use of natural immunomodulators including the use of dialyzable bovine
colostrum extract can be concluded as a viable therapeuticum in NK cell
reactivation in the face of Chronic Illness.
Clinical Study Summary and Discussion
The participants:
Charts of 107 patients who presented with chronic illness which were known to
include low NK cell function were studied to determine their NK cell function
response after being treated with a complimentary medical regimen of therapy.
This regimen included the use of dialyzable bovine colostrum/whey extracts as
well as other elements of the Holistic Medical Paradigm.
The patients all self-selected this medical approach and most came with specific
expectations having read (1) Chronic Fatigue Syndrome: The Hidden Epidemic
or, (2) The Definitive Guide to Cancer Therapy.
An overview of the immune system:
The marvelous array of deftly interacting cells that defend our
invaders arise from a few precursor cells that first appear at about
conception. From that point on, the cells of the immune system
continuously repeated cycle of growth and development and
competent at around 6 months of age after our birth.
body against
9 weeks after
go through a
become fully
The parent cells of our immune system are referred to as stem cells. These are
the cells upon which the immune system depends to both reproduce itself and
gives rise to the many specialized lineage's that spring from it; the B cells,
macrophages, natural killer (NK) cells, helper T cells, etc.
The cells of the immune system are not isolated in a single body space or
arranged in the form of a single organ. Instead, the majority of them exist as
potentially mobile entities unattached to other cells. This characteristic is crucial
to their function. Every minute of every day, war is waged within our body. The
combatants are too small to see. Some, like the infamous HIV virus, are so small
that 230 million would fit on the period at the end of this sentence. Yet, they
employ tactics that can vanquish the much larger cells upon which our immune
system is based. Usually, we never even notice the battles within us.
We have evolved legions of defenders, specialized cells that silently destroy the
unseen enemy. Sometimes these warriors mistake harmless invaders such as
pollen for deadly foes and trigger an allergic response. Occasionally, some of our
own cells begin the mutinous uncontrolled proliferation characteristic of cancer
and manage to evade the surveillance of our body's defensive forces. For every
successful penetration of our defenses, millions of attempts are repelled. We
sleep securely at night trusting the invisible vigilantes of our immune system.
The science and practice of immunology traces back to 1721 to Lady Mary
Wortley Montagu. She introduced England to a Turkish process of inoculation
with unmodified smallpox virus in an attempt to stem the ravages of the normal
course of the disease. Her techniques were quite crude and as many as her
patients died as survived but those that survived were immune to the disease
forever more.
Over the decades and centuries scores of doctors and researchers honed the art
of immunology into a more and more refined science. Many of the wonderful
blood tests that we have today and information that we now know about
immunology was unknown to us a scant 20 years ago. Information on the
science of immunology doubles at the rate of approximately every 5 to 6 years.
So we must remember that the wonderful ways that we have today to support
and direct the immune system to help protect us and fight off illnesses is a mere
foreshadow of things to come in the (near) future
Our immune system is a miracle of evolution. There is interesting research to
suggest that elements of our immune system were, at one time, actually
independent organisms. They were incorporated into our body millions and
millions of years ago as a type of symbiotic mutually beneficial relationship. Our
immune system is not controlled by any central organ such as the relationship of
our brain to our nervous system. Rather it has developed and functions as a kind
of biological democracy where the individual members achieve their ends
through an information network of biochemical substances called cytokines.
Many different variables in our environment and lifestyle can effect the efficiency
of its function. Our immune system accounts for approximately 1% of our body's
100 trillion cells. These defender cells originally arise in our bone marrow and
mature in other parts of our body, the thymus, spleen and lymph glands. The
different lineage's which develop all share one common objective; to identify and
destroy all substances, living or inert, that are recognized as foreign to our body.
This includes cancer cells that challenge our immune system everyday for each
and every one of us.
NK Cells:
NK cells were discovered in the 1970's and constitute up to 15% of the total
lymphocyte population in normal healthy subjects. They are capable of killing a
broad range of tumor and virus infected cells. Depressed NK cell activity and
depressed NK cell populations are associated with the development and rapid
progression of cancer, hepatitis, AIDS, Chronic Fatigue Syndrome, various
immunodeficiency syndromes, and certain autoimmune diseases. In my practice
I almost exclusively work with people with severe and chronic diseases, diseases
that are known to present abnormally low levels of NK cell function.
NK cells now appear to present the first line of defense against metastatic spread
of tumors. In numerous studies, low NK cell populations were correlated with
greater and more rapid spread of tumors with shorter host longevity and with
greater morbidity.
The immune response:
There are four critical phases to the immunological response and lifestyle issues
and some dietary supplements can influence them.
During phase one, the offending invader is identified and recognized as
being foreign to our body and then quickly consumed by hungry roving
macrophages. You can think of macrophages as little PAC men that are
found in all of the tissues in our body and circulating around in our blood
stream looking for their next free lunch. They seize upon this foreign
agent, engulf it, eat it and release a series of cytokines that then trigger
the 2nd phase of the immunological reaction.
In phase two, these biochemical substances then activate the helper T
cells that have the job of coordinating the counterattack on a body-wide
scale. The T cells then begin to multiply and release other cytokines that
further stimulate more T cells, B cells, and natural killer cells. As the
number of B cells increase, the helper T cells signal them to begin
producing antibodies, thus, bringing us to the 3rd stage of the
immunological response.
In the third stage, the antibodies are circulating around in our blood stream
and are attaching to the foreign virus or bacteria causing them to be more
quickly engulfed by macrophages or killed by natural killer cells.
The fourth stage of the immunological response begins when the
circulating antibodies no longer have a target and the suppresser T cells
call a truce to the immunological reaction bringing about a new balance, or
homeostasis, in our system. Special cells of the immune system
remember what had transpired so that if again attacked by the same
organism our body could respond much faster. These cells also release
special little molecules called transfer factor to help keep the pump
primed, so to speak.
Thus, what may have been a 10-day bout from our first exposure to that
particular virus, in the future may be a cold that lasts no more than 24-72
hours.
Immune-modulation:
Immune-modulation is a new and key step in supporting immune function. This
can include a number of different substances, depending upon the situation,
including: transfer factor (obtained in specially prepared colostrum/whey
extracts), Astragalus, Arabinogalactan, Viscum extracts, vitamin C, iodine,
lactoferrin, certain amino acids, neurotransmitter hormones and the prohormone
DHEA.
Transfer Factor:
In the study group generic NK cell response was monitored using transfer factor,
obtained in specially prepared colostrum/whey extracts, along with the herb
Astragalus that is known to accelerate and support immunological reactions. The
transfer factor component was produced from cows that have been
immunologically stimulated using a patented process. This process does not hurt
the cow. In fact, it stimulates the cow’s immune system for its own protection.
When a cow gives birth to a calf, the first flow of milk is called the colostrum. The
colostrum is collected and the transfer factor molecules are extracted. At
appropriate opportunities, collection can also occur from the milk following
colostrum. This is generally referred to as whey. Since none of the milk proteins
remain, these products are safe even for people with a dairy allergy. The purified
transfer factor can then be given to people to passively stimulate their NK cells
function to alert-activity status, thus protecting them to a significant degree from
illness as well as helping them recover from illness.
Lifestyle:
Lifestyle issues that will affect the functioning of our immune system include
exposure to toxins (heavy metals, petrochemicals, radiation, etc.) and dietary and
nutritional deficiencies that can rob the immune system of the biochemical
foundation that it relies upon in order to function normally. Another major lifestyle
issue relative to immune function is stress.
Dietary supplements used by the Study Group:
The use of other nutritional support factors in conjunction with the dialyzable
colostrum/whey extract and astragalus was important for patient recovery.
However, I want to point out three significant factors in relation to that fact:
1.
Most of the patients were advanced in their conditions and had tried
other approaches for their health recovery before I saw them in my
clinic.
2.
The dialyzable colostrum/whey extract was critical to their recovery.
Without that component, providing the transfer factors discussed
herein, many of the patients simply would not have recovered.
3.
I have utilized a wide array of well-known and privately prepared
colostrum products with disappointing results. These products
were not helpful to my patients as they failed to significantly
increase NK cell function or consistently provide any other
significant immunological benefits that could be measured.
I also observed that people who were not severely compromised responded well
to daily supplementation of the colostrum/whey extract and astragalus without
additional nutritional supplementation. Even though adequate nutritional support
is important it was noted that the extract of dialyzable colostrum/whey and
astragalus is very powerful and valuable in combination without additional
supplementation.
The importance of prevention:
With any health problem it is much more prudent and efficient to prevent disease
by maintaining a high level of immune function. Research has shown that low
NK cell activity is present nearly all illness. A daily dietary regimen that includes
dialyzable bovine colostrum/whey extract has been shown to significantly help
maintain high NK cell activity and thereby dramatically increase the ability of the
immune system to maintain a healthy condition.
Conclusions:
This Study Group demonstrates that stimulation of NK activity paralleled restored
resistance to illness and recovery from illness. NK cell activity is correlated with
disease status in those patients with hematologic malignancy such as leukemia
and lymphomas as well. In some studies, on patients with leukemia, a sudden
and maintained decrease in NK cell activity was reported nearly always to
proceed relapse even if the patient had been in complete remission for some
time. This also correlated with a general drop in the percentage of lymphocytes
as measured in a standard blood test. NK cell function is a well-regulated activity
subject to both inhibitory and excitatory control.
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Study Group Profile
Background:
NK cell activity (Lytic Units) in
a healthy population
NK cell activity (Lytic Units) in
the U.S. population
150-225
20-50
Study Group size and gender:
107 participants
59 females
48 males
Average age
Youngest
Oldest
53 years
17 years
83 years
Presenting disease as a percentage of the Total Study Group:
Cancer
50%
Chronic Fatigue Syndrome
30%
Others
20%
Including Lupus, Allergies, Fibromyalgia, Blood Disorders, Chronic
Infections, Recurrent Infections, Autoimmune Diseases, and
Cervical Dysplasia/Metaplasia.
All Study Group participants recorded significantly higher NK cell activity.
Average initial NK cell activity
18 Lytic Units.
Average final NK cell activity
246 Lytic Units.
Average monthly increase in NK cell
activity by participants
Average percentage of improvement
28.25 Lytic Units.
1,267%.
Treatment period:
Total participant treatment time
1,422 months.
Average participant treatment time
13.2 months.
Number of capsules used by participants
2-8 per day.