Download overcoming obstacles: barriers to care in fibromyalgia treatment

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OVERCOMING OBSTACLES:
BARRIERS TO CARE IN FIBROMYALGIA TREATMENT*
—
M
Steven P. Cohen, MD†
ABSTRACT
Many patients with fibromyalgia syndrome
(FMS) receive inadequate or ineffective treatment, often because of multifactorial barriers
that stand in the way of appropriate care.
These barriers include the high prevalence of
medical and psychiatric comorbidities in
patients with FMS, the challenges inherent in
diagnosing FMS, and the perception among
many that FMS is not a “real” disease. Another
major obstacle is that there is often little or no
coverage for patients with FMS who do have
health insurance, and restricted access to
healthcare for those who do not. This article
reviews these and other patient-, physician-,
and process-related barriers and explains how
they interfere with treatment. The article also
suggests several common-sense strategies
aimed at overcoming these obstacles and
improving care for patients with FMS.
any patients with fibromyalgia syndrome (FMS) receive inadequate or
ineffective treatment. In part, this is
a direct reflection of the lack of consensus among clinicians with respect
to diagnosis, causes, and effective treatments. In large
measure, however, inappropriate care can be attributed
to numerous multifactorial barriers that need to be
overcome.
These barriers fall into 4 broad but interrelated categories: patient-related factors; physician-related factors; work and social impairment; and factors
involving “process,” such as delayed diagnosis and
inadequate healthcare coverage. The categories overlap
to some extent, just as FMS frequently overlaps with
several other pain syndromes and psychiatric conditions. Factors in each of the categories are reviewed in
detail in this article, as well as strategies to overcome
these obstacles.
PATIENT-RELATED FACTORS
(Adv Stud Med. 2009;9(4):115-121)
*Based on a presentation developed by Dr Cohen for a
national symposium series held in October and November
2009.
†Associate Professor of Anesthesiology, Director of
Medical Education for Pain Management Division, Johns
Hopkins University School of Medicine, Baltimore,
Maryland; Director of Chronic Pain Research, Walter Reed
Army Medical Center, Washington, DC.
Address correspondence to: Steven P. Cohen, MD,
Associate Professor of Anesthesiology, Director of Medical
Education for Pain Management Division, The Johns Hopkins
Pain Management Division, 550 North Broadway, Suite
301, Baltimore, MD 21205. E-mail: [email protected].
Johns Hopkins Advanced Studies in Medicine
n
Patient-related barriers to appropriate care include
the often desperate attempts of many patients to find
a “cure,” which can undermine relationships and the
ability to function at work. Patients with FMS have a
higher prevalence of coexisting psychopathology,
which may predate the physical symptoms of FMS.
Depression, anxiety disorders, and post-traumatic
stress disorder are the most common psychiatric diagnoses, but some studies have found a higher incidence
of Axis II disorders as well. Studies conducted in
patients with FMS with and without comorbid psychopathology strongly support the usefulness of cognitive-behavioral therapy.
Other patient-related barriers include cognitive
impairment, a host of sleep disturbances, and the high
degree of overlap between FMS and several other con-
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these other syndromes. Patients complaining of chronic widespread pain should therefore be evaluated not
only for FMS, but also for chronic fatigue syndrome,
multiple chemical sensitivities, irritable bowel syndrome, temporomandibular joint disorder, and other
somatoform pain disorders that commonly coexist
(Table 1).9,10
Figure. Proportion of Patients with FMS Reporting
Worsening of Pain After Sleep by Alpha Intrusion
Subtype
100
100
75
Patients, %
ditions that share similar clinical features. The cognitive impairment associated with FMS, sometimes
referred to as “fibrofog,” involves all aspects of memory, attention span, and task-switching. Pain and psychological, sleep, endocrine, and social problems can
all exacerbate cognitive deficits.
Sleep disturbances—particularly nonrestorative
sleep, insomnia, early morning awakenings, poorquality sleep, delayed sleep latency, daytime fatigue,
increased nocturnal physical activity, and easy arousability—are common in patients with FMS.1-3 In a
recent study, up to 99% of patients reported having
sleep problems; patients with FMS get an average of 5
hours of sleep per night compared with 7 to 8 hours
per night for controls.3
Polysomnographic studies in patients with FMS
suggest abnormalities in sleep continuity as well as
sleep architecture.1,2 Rapid eye movement (REM)
sleep, slow-wave sleep, and total sleep time are
decreased. Sleep efficiency is further compromised
because of an increased number of awakenings. In
addition, there is abnormal alpha-wave intrusion in
non-REM sleep.
Alpha-wave intrusion—particularly of the phasic,
tonic, and low alpha subtypes—is a common but nonspecific electroencephalographic finding in patients
with FMS that may interfere with sleep function and
contribute to worsening of pain.1,2 As demonstrated in
a polysomnographic study of patients with FMS, phasic alpha sleep activity correlates strongly with worsening pain after sleep (Figure).1 Patients with phasic alpha
activity also report longer duration of pain after sleep
than patients with tonic alpha or low alpha activity.
The history of the relationship between sleep and
FMS is a long one, with early findings suggesting that
FMS-like symptoms could be induced by stage 4 sleep
deprivation, and that the “fibrositis” symptom complex should perhaps be considered a “nonrestorative
sleep syndrome.”4 More recent findings have demonstrated inspiratory airflow dysfunction,5 a cyclic alternating pattern strongly correlated with the severity of
FMS symptoms,6 sympathetic overdrive,7 and restless
leg syndrome during sleep.8 Although treating these
sleep-related problems is likely to benefit the patient,
it clearly will not eradicate all FMS symptoms.
Diagnosing FMS is a challenge because it is only
one of several overlapping systemic and regional pain
syndromes with shared clinical features.9 It is not
unusual for patients with FMS to have 1 or more of
P <.001
58
50
25
25
0
Phasic Alpha
Tonic Alpha
Low Alpha
Reprinted with permission from Roizenblatt et al. Arthritis Rheum.
2001;44:222-230.1
Table 1. Prevalence of Selected Comorbid
Conditions in Patients with FMS
Comorbid Conditions
Prevalence, %
Chronic fatigue syndrome
21–80
Irritable bowel syndrome
32–80
Temporomandibular joint disorder
75
Headache (tension-type and migraine)
10–80
Multiple chemical sensitivities
33–55
Interstitial cystitis
13–21
Chronic pelvic pain
18
FMS = fibromyalgia syndrome.
Data from Aaron and Buchwald.10
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Further complicating the diagnostic challenge is
the frequent overlap between FMS and several psychiatric diagnoses, including major depression, obsessive
compulsive disorder, bipolar disorder, post-traumatic
stress disorder, generalized anxiety disorder, and panic
attacks.
PHYSICIAN-RELATED FACTORS
Physician-related factors that can lead to ineffective
care reflect how challenging it is to diagnose FMS and
deal with patients who are often considered “difficult.”
Even in patients who are not considered difficult, diagnosing and managing FMS is a time- and labor-intensive endeavor because of multiple physical
comorbidities and a high incidence of coexisting psychopathology. Moreover, treatment success rates are
low, often leading to disappointment, frustration, and
even anger for patients and physicians alike.
Difficult patients exhibit several distinguishing
characteristics. They bring out a clinician’s negative
feelings, fail to respond to multiple treatments, and do
not comply with clinician recommendations. They are
more likely to be “doctor shoppers,” with unrealistic
expectations and low satisfaction rates. In addition to
poor functional status and a high incidence of Axis I
and Axis II disorders, they utilize a disproportionate
share of healthcare resources and require a considerable amount of labor-intensive paperwork to support
claims for disability benefits.
Difficult patients can be labeled as dependent
clingers, entitled demanders, manipulative help-rejectors, or self-destructive deniers.11 The identifying features of each of these patient “labels,” along with
recommended treatment approaches, are summarized
in Table 2.
The diagnosis of FMS relies on a careful review of
the patient’s medical, family, and social history, along
with a thorough physical examination. The medical
and family histories should focus on the presence of
other pain syndromes, particularly regional somatic
and visceral pain syndromes, and the social history
should determine whether (and which) symptoms are
triggered or exacerbated by “stressors” such as cold
weather or exertion, and if there is any substance abuse.
Physical examination findings are often normal
except for diffuse pain and tenderness. It is important
to note, however, that tenderness is not necessarily confined to the joints or the tender points identified in the
American College of Rheumatology diagnostic criteria.12 In addition, weakness and sensory disturbances
have been found to affect a majority of FMS sufferers.13
Another physician-related factor is the lingering
question about the precise categorization of FMS (ie, is
it a syndrome or is it a disease?). By definition, a syndrome lacks unequivocal diagnostic criteria, has no
readily identifiable etiologic agent or well-defined
pathophysiologic mechanisms, lacks characteristic
physical signs, is associated with other poorly explained
syndromes, is considered a “diagnosis of exclusion,”
Table 2. Identifying Features and Treatment Strategies by Patient “Label”
Patient “Label”
Identifying Features
Treatment Strategies
Dependent clingers
Escalating need for re-assurance and become
increasingly helpless
Set appropriate limits with realistic
expectations
Entitled demanders
Initially present as “needy,” but then exhibit
aggressive and intimidating behavior
Control “anger,” acknowledge situation, and
discuss expectations
Manipulative help-rejectors
Ungrateful and pessimistic about treatment
Paradoxically advocate skeptical attitude to
therapy and schedule regular appointments
Self-destructive deniers
Engage in behaviors that thwart attempts to
improve their condition (eg, drinking)
Avoid vengeful feelings and focus on
underlying depression
Reprinted with permission from Wasan et al. Reg Anesth Pain Med. 2005;30:184-192.11
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and generally carries a poor prognosis. By these standards, FMS is clearly a syndrome and not a disease.
WORK AND SOCIAL FACTORS
Work-related factors are important drivers of the
economic burden of FMS. As shown in numerous
studies, FMS is associated with increased utilization of
healthcare resources and high job- and productivityrelated costs. Among patients with rheumatologic
problems, one study found that FMS, osteoarthritis,
and rheumatoid arthritis (RA) were associated with the
highest likelihood of long-term disability.14 A comparative analysis of the economic burden of FMS and RA
found that costs associated with disability and missed
work days were similar for both, but that patients with
FMS accounted for more emergency department and
physician visits.15
Several studies examining the impact of FMS in
the workplace found that annual indirect costs due to
lost productivity ranged from $535 to $3411 among
employees with FMS compared with $221 to $1699
among employees without FMS.16-19 Lost productivity
was variously defined in these studies as work
loss, workplace payments, lost wages, disability, or
absenteeism.
Two of these studies also examined the impact of
FMS alone, depression alone, and coexisting FMS and
depression on direct and indirect costs in the workplace.16,17 Both studies found that annual costs in
patients with coexisting FMS and depression were
higher than the sum of the individual costs of each condition. In one study, for example, the individual costs
of FMS alone and depression alone totaled $10 262,
but the costs of coexisting FMS and depression were
$10 611.16 The corresponding costs in the other study
were $8264 and $9413.17
Fibromyalgia syndrome is associated with comparatively high levels of healthcare utilization and expenditures. One study demonstrated that 1-year total
healthcare costs were 3 times higher in patients with
FMS than in age- and gender-matched patients who
did not have FMS.20 Another study found that patients
with FMS accounted for substantially more visits and
prescriptions per year (25 visits and 11 prescriptions)
than matched controls (12 visits and 4.5 prescriptions).21 Patients with FMS in this study also underwent more testing for a period of at least 10 years prior
to diagnosis. In yet another study, 61% of patients
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with FMS reported spending $100 to $500 per month
on prescription medications.22
Although patients often report that FMS has had
an adverse effect on their relationships and social functioning, social factors per se have been poorly studied.
Several studies show a possible link between FMS and
obesity, smoking, and divorce,23-25 whereas studies of
patients with chronic pain or illness due to any cause
indicate a divorce rate of approximately 75%.26
Chronic pain may also play a role in suicide.
FACTORS INVOLVING “PROCESS”
Factors involving “process,” which can be summarized as navigating through the healthcare system from
diagnosis to treatment and follow-up, are major barriers to appropriate care. First, many physicians do not
recognize FMS as a “real illness,” a circumstance that
usually results in inadequate or ineffective treatment,
or even no treatment at all. Second, many interventional pain clinics will not see patients with FMS
because of lack of insight and/or financial reasons.
And third, many insurance companies will not pay for
the extended physical therapy, cognitive-behavioral
therapy, or other expensive treatments that FMS often
requires.
Failure to recognize FMS as a real illness may also
play a role in its delayed diagnosis, which averages 4 to
5 years after symptom onset,27 and in prompting multiple patient visits to multiple providers. In a study by
Dobkin et al, 178 women with primary FMS saw an
average of 7.2 physicians and 11.3 complementary/
alternative medicine providers during a 6-month period.28 More auspiciously, another study found that the
initial diagnosis of FMS—made by family physicians
who referred patients to a rheumatology clinic—was
confirmed in 71% of referrals.29
Reduced access to healthcare is another major barrier to effective treatment. Of the 47 million
Americans who do not have medical insurance, more
than 17 million are women over the age of 18 years,
the population most likely to be affected by FMS.30
Uninsured patients, regardless of gender, are more likely to suffer serious health problems. However, having
health insurance is no guarantee of receiving adequate
treatment because many policies exclude, or provide
only partial coverage for, certain conditions, including
FMS. In fact, among women who do have health
insurance, over 50% have either failed to fill a pre-
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scription or postponed or went without medical care
because of cost concerns.31
A disproportionate number of uninsured people in
the United States have low educational levels and
socioeconomic status. Studies in the United States,
Spain, Sweden, Israel, and Finland confirm that
patients with FMS, regardless of their insurance status,
are more likely to have low education levels and
socioeconomic status.32-36 These studies also confirm
that there is an inverse correlation between educational and socioeconomic levels and the severity of disability related to FMS.
OVERCOMING OBSTACLES
Several strategies have been suggested to overcome
barriers to care in patients with FMS. These include
patient and physician education, better communication between patients and healthcare professionals,
medication counseling, and improved access to healthcare. Several common-sense treatment strategies that
can be implemented in primary care practice are summarized below:
•
Establish realistic expectations and an
approach to treatment that is acceptable to
the patient.
•
Address sleep abnormalities if present.
•
Use a multidisciplinary approach to treat
coexisting physical conditions.
•
Identify underlying psychological/psychiatric
issues and treat/refer accordingly.
•
Incorporate a structured exercise program, if
indicated, into the treatment regimen as early
as possible.
•
Recognize and develop treatment strategies
for “difficult” patients (Table 2).
•
Educate and involve patients and family
members, particularly spouses, about FMS.
•
Utilize social work services and networks to
maximize available resources for uninsured
and underinsured patients.
CONCLUSIONS
Barriers to appropriate care for patients with FMS
are multifactorial. These barriers can be broadly categorized as patient-related, physician-related, workrelated, and/or process-related.
Early interventions and a multidisciplinary
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approach to treatment may minimize, but not eradicate, these obstacles and ultimately result in improved
patient care.
CASE STUDY
PRESENTATION AND H ISTO RY
A 51-year-old woman with a 5-year history of diffuse body pain and a diagnosis of FMS presents with
worsening pain that she attributes to “overexertion and
watching the kids,” weakness, and occasional numbness. She describes her pain as “sharp, burning, tingly,
gnawing, achy, stinging, and crushing,” and she notes
that it is exacerbated by cold weather, activity, and
stress.
She has a medical history significant for low back
pain, abdominal pain secondary to irritable bowel syndrome, and headaches. Her surgical history is remarkable for cholecystectomy and appendectomy. A
detailed review of systems notes a long history of
insomnia and symptoms consistent with depression.
A former gymnast and tennis player, she is currently unemployed and recently separated, with custody of
2 teenagers. She is a recent smoker and has a family
history of depression, but no history of substance
abuse. She is not currently involved in a relationship
and reports having no libido.
At presentation, she was taking sertraline 50 mg once
daily, clonazepam 1 mg 3 times a day, extended-release
oxycodone 80 mg 3 times a day, immediate-release oxycodone 10 mg every 4 hours as needed, topiramate 200
mg/day, a multivitamin, and a bisphosphonate.
PHYSICAL EXAMINATION AND D IAGNOSTIC
EVALUATION
Physical examination reveals a slightly overweight,
agitated woman in obvious distress. She is diffusely
tender to very light palpation with less than 2 kg/cm2
of pressure applied bilaterally, above and below the
waist, and has several positive Waddell’s signs for low
back pain, which indicate nonorganic pathology and a
poor treatment prognosis.37 She also exhibits overreaction and patchy, nondermatomal areas of numbness,
but no focal neurological signs.
The diagnostic workup includes magnetic resonance imaging of the spine, which reveals mild-tomoderate spondylotic changes in the lumbar and
cervical regions, and the brain, which is normal. The
white blood count is normal as well.
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The differential diagnosis includes FMS, central
pain disorder, somatoform disorder, opioid-induced
hyperalgesia, and malingering/secondary gain. The latter is unlikely because she is not on or seeking disability, and she is receiving financial support from her
husband.
The absence of any preceding neurological event,
focal neurological signs or symptoms, and spasticity
eliminates central pain disorder. Her pain pattern was
not consistent with a somatoform disorder. Although
the distribution of her pain is consistent with a clinical diagnosis of FMS, she did have some evidence of
opioid-induced hyperalgesia. Specifically, pain to
extremely light touch is a hallmark of neuropathic pain
or some other type of nociceptor sensitization, not
FMS. The extremely high doses of opioids she was taking therefore likely signify a combination of clinical
tolerance and opioid-induced hyperalgesia.
N ONPHARMACOLOGIC TREATMENT
The patient was referred to a sleep clinic, where she
was given sleep counseling. After giving informed consent, she signed a 3-way contract (patient, pain clinic,
and primary care physician) which made the pain clinic the sole prescriber of all controlled substances. By
signing, she explicitly agreed to an opioid taper over 2
months and a benzodiazepine transition to cyclobenzaprine, a muscle relaxant with demonstrated benefit
in FMS. She was also referred to a pain psychologist,
who initiated cognitive-behavioral therapy and taught
her how to utilize relaxation techniques and develop
coping skills.
At the same time, she agreed to restart a daily exercise regimen, which included flexibility and strength
training along with an emphasis on aerobic training,
and to keep an exercise diary. Because many patients
do not respond adequately to exercise treatment
because of poor compliance secondary to pain, she
began her aerobic training with simple walking.
PHARMACOLOGIC TREATMENT
Pregabalin was started, with the dose initially titrated to 225 mg twice a day, and then increased to 300
mg twice a day. The attempted switch to cyclobenzaprine 5 mg twice a day was changed to 8 mg twice a
day, and eventually increased to 10 mg 3 times per day.
The patient was able to discontinue most of her benzodiazepine, but continued to take clonazepam 0.5 mg
at bedtime. On a similar note, she was also unable to
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taper off opioids completely, but did manage an
approximately 90% decrease in her total dosage to fentanyl patch 12.5 µg per hour plus a single
hydrocodone/acetaminophen tablet per day as needed.
Over the next 3 months, she reported a 25%
reduction in symptoms, with resolution of allodynia
and redevelopment of the classic FMS pain pattern.
However, insomnia recurred with the tapering of opioids and benzodiazepines. At this point, after “buy in”
from her psychologist and primary care physician, she
was switched from sertraline to duloxetine 60 mg orally at bedtime because the latter has shown benefit in
alleviating pain and improving sleep in FMS.
As her depression resolved, she began working
part-time for a medical billing company. Protriptyline,
a tricyclic antidepressant that can reduce drowsiness,
was added when she noted that daytime fatigue and
lethargy were interfering with her productivity at
work. Dextromethorphan, an oral N-methyl-D-aspartate receptor antagonist, was also added after a positive
intravenous ketamine infusion test.38
C URRENT STATUS
She reports a 60% reduction in pain and appears to
be doing well. She received a promotion to assistant
manager, lost 10 pounds, and has started dating again.
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