Download Aplikasi dendrimer sebagai sistem penghantar obat

Aplikasi dendrimer sebagai sistem penghantar obat-obatan
Aplikasi dendrimer sebagai sistem penghantar obat-obatan
Dendrimer application as drug delivery system
JURNAL KEDOKTERAN YARSI 12 (2) : 096-106 (2004)
by
Yuhernita
Department of Chemistry, YARSI UNIVERSITY School of Medicdine Jakarta
ABSTRACT Many studies in design, synthesis and polymer properties have been conducted to
discover a new polymer that can be used as a drug delivery agent. Due to the improvement of
drug targeting and therapeutic efficacy, various polymer carriers have been evaluated.
However, the inability of drug or steric constrains of polymeric systems to reach the target site
decreased drug activity. Dendritic polymers are considered alternative for the preparation of
monodisperse drug carriers due to their well-defined structure, multivalency, and flexibility of
functionalization. These unique properties have made their application in pharmaceutics and
chemistry particularly attractive. This review elaborates the preparation of dendrimer and their
potency for many applications, especially in drug delivery system.
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