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Download The interaction of galectin-3 with a lactose-functionalized PAMAM dendrimer is... Jesse Cook: Chemistry & Biochemistry
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Jesse Cook: Chemistry & Biochemistry Mentor: Mary Cloninger -- Chemistry & Biochemistry Lactose-functionalized PAMAM Dendrimer Effects on Cancer cell Aggregation The interaction of galectin-3 with a lactose-functionalized PAMAM dendrimer is monitored through aggregation assays with the human cancer cell lines HT-1080 and A-549. It is hypothesized and shown that the generation-2 dendrimer (relatively small) will inhibit aggregation (Figure 3.6 a). Also hypothesized is that the larger dendrimers will induce aggregation by aiding in cross-linking of cells (Figure 3.6 b), but results are inconclusive. 157
