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____________________________________________ ANTIOXIDANT - IMMUNE DEFENCE ______ Bio-C-Vitamin What is Bio-C-Vitamin? Bio-C-Vitamin is film-coated tablets with 750 mg of vitamin C in the form of non-acidic calcium ascorbate in a pharmaceutical quality. Bio-C-Vitamin can be taken with or without a meal. Pregnancy Bio-C-Vitamin may be used by pregnant and lactating women. Side effects Bio-C-Vitamin is not associated with any known side effects. What is vitamin C? Vitamin C’s chemical name is ascorbic acid which means: The acid that counteracts scurvy. Vitamin C is a water-soluble vitamin and an antioxidant that is part of several intra-cellular redox systems involved in neutralising reactive oxygen compounds (also known as free radicals). Vitamin C is a so-called co-factor in different enzymatic processes. Vitamin C distributes itself through the body’s water phase, which includes everything that is not fat and bone tissue. The vitamin C concetration in the brain is 10 times higher than what it found in blood. The highest concentration is found in white blood cells and blood platelets. The adrenal glands and pituitary gland plus the testicles and ovaries have particularly high concentrations of vitamin C. Mammals produce their own vitamin C Almost all mammals are able to synthesize vitamin C in their adrenal glands by means of an enzymatic conversion of glucose. In these animals vitamin C works like a hormone. In humans, on the other hand, the gene of the vitamin C-producing enzyme contains a number of mutations resulting in an inability to produce the vitamin and therefore we depend on it from our diet. Increased need Humans have an increased need for vitamin C in situations with oxidative stress like e.g. large lesions, burns, and serious infections. Also, smokers have increased need for vitamin C. Bio-C-Vitamin 1 tablet contains Vitamin C (as calcium ascorbate) RDA% 750 mg 938% Ingredients Calcium ascorbate, microcrystalline cellulose, hypromellose, silicon dioxide, magnesium stearate, talc, titanium dioxide. Dosage 1 tablet daily, unless otherwise advised. Storage Dark, dry and at room temperature. Keep out of reach of young children. Do not exceed the recommended daily dosage. Preferably after a meal as a whole take. A healthy lifestyle and a varied balanced diet is important for maintaining good health. Dietary supplements should not replace a varied diet. Suitable for vegetarians. Properties of Vitamin C: • Is an important antioxidant that is involved in intra cellular redox systems. The exact mechanism of action is not known. • Is almost fully absorbed from the intestine in dosages of about 100 mg daily. At higher dosages or in the case of diarrhea, the absorption is reduced. • Is able to regenerate vitamin E which have been damaged by encounter with free radicals • Maintains the enzyme propyl hydroxylase in its active form which helps to hydroxylate recently produced connective tissue (collagen). The deficiency symptom known as scurvy is a result of insufficient collagen hydroxylation. • Is important for our energy-yielding metabolism, our immune and nervous system and also psychological functions. It increases non-haem iron from our food • Is able to reduce tiredness and fatique Good sources of vitamin C Good and natural vitamin C sources include foods such as: • Rosehips • Acerola • Bell pepper • Vegetables • Cabbage • Citrus fruits Vitamin C and drugs Consuming vitamin C may influence the effect of certain drugs (including natural remedies) and food. Concurrent ingestion of deferoxamine (iron-binding remedy) increases this effect. Large doses of vitamin C may affect the way anticoagulants work. A possible interaction between medicine and vitamin C has only been observed with some drugs. When to avoid Vitamin C supplements Vitamin C increases the absorption of iron and should therefore not be taken by people with iron overload problems. In addition, Bio-C-Vitamin should not be used by people who tend to develop kidney stones, have impaired renal function or glucose 6-phosphate dehydrogenase deficiency. Rare cases of diarrhea and indigestion have been reported from large intake of vitamin C. Overdosing Vitamin C overdosing rarely occurs, as a vitamin C surplus is normally excreted in the urine. Ingesting more than 2 grams of vitamin C daily may in some people cause a completely harmless state of diarrhea known as osmotic diarrhea. In some cases, bloating and nausea are seen. Large vitamin C quantities are also able to increase urine levels of oxalate in some people with a tendency to hyperoxaluria, which is a rare condition that may increase the risk of producing stones in the urinary tract. Any surplus of vitamin C is excreted in the urine as oxalate in unchanged form. Overdosing is treated symptomatically with remedies like medical coal and/or antiacids. Discontinuation of excessive vitamin C consumption If one suddenly stops consuming vitamin C after having ingested large quantities of the vitamin for a prolonged period of time it may cause vitamin deficiency symptoms – also called a so-called rebound phenonemon.