Download Main objective is to expand current limited management options for

Main objective is to expand current limited management options for the diagnosis and treatment of GBM. In particular,
the aim of this applicationis to provide a nanotool with the ability to circumvent the recurrent problems of brain delivery
and thus improve the therapeutic of the Temozolomide. Moreover, MNPs will be also inside the PNPs thus allowing an
imaging approach against GBM.
The synthesis of MNPs based on metal and bimetallic Fe based NPs is in charge to the unit from LNT (Vietnam), the
main objective will be to obtain high magnetic properties and keep them after the nano-formulation inside the PNPs. The
expertise of the University of Bologna in doing nanoformulations will take advantage by the LNT and their synthesis
of innovative magnetic NPs for bioimaging.
The development of a new, selective and efficient organic coating for the above mentioned magnetic NPs will be in
charge to bologna’s unit.Multiple outer-shell decoration with two specific peptides (Chlorotoxin and Labradimil) will
also be a main synthetic objective of Bologna, since achieving multiple functionalities on nano-platforms is still a
challenge. Finally, the development of a stable and reproducible protocol for the large-scale synthesis of the final
PNPs (scaled up to one gram of polymer) will be addressed as an important objective for future clinical applications.
The aim of the imaging activity in collaboration with the italian industry, Ephoran-Multi-Imaging Solutions, Italy, is
to characterize the nanoparticles formulations in order to evaluate their relaxation properties by MRI in vitro and ex-vivo
and observe tumor size reduction after drug delivery. The second aim is to evaluate nanoparticles distribution and
permanence in organs and in tumor after intravenous administration both in healthy and in tumor bearing mice.