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Download the reciprocal interaction model of sleep cycle control
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THE RECIPROCAL INTERACTION MODEL OF SLEEP CYCLE CONTROL Allan Hobson Department of Psychiatry Harvard Medical School RECIPROCAL INTERACTION Pontine NREM-REM Oscillator Aminergic-Cholinergic Neuronal Interaction Role of Hypothalamus EXTRACELLULAR MICROELECTRODE RECORDING TECHNIQUE Ralph Gerard (1953) David Hubel (1959) Edward Evarts (1960) Edward Evarts Cortical Motor Neuron Discharge Roger Broughton Nightmares and Sleep Walking Adrian Morrison PONTINE NEURONS Giant Cells-Glutaminergic REM Off Cells-Aminergic REM On Cells-Cholinergic GIANT CELLS Project to Oculomotor Neurones Project to Spinal Cord Sensorimotor Integration REM OFF CELLS Noradrenergic-Locus Coeruleus Serotonergic-Raphē Nuclei Helen Baghdoyan and Ralph Lydic Dorsal Raphe Nucleus Neuron Discharge Cell Discharge Cycle Averaging RECIPROCAL INTERACTION MODEL Allan Hobson and Robert McCarley Reciprocal Discharge Patterns REM OFF REM ON WAKE NON REM REM Synaptic Model REM On REM Off MATHEMATICAL MODEL dx/dt=ax-bxy dy/dt= -cy+dxy FUNCTIONAL SIGNIFICANCE Converts Genetic Blueprint into Dynamic Program for Brain
