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How do we fight disease? Immune System Pathogens • Microorganisms that make us sick are called pathogens • Diseases caused by pathogens are called infectious diseases Types of pathogens • Bacteria – example: strep, tetanus • Viruses: – colds, flu • Fungi: – athlete’s foot & ringworm • Protists: – amoebic dysentery How are pathogens spread? A. Contact with an infected person • • – – – 1. Direct contact: kissing, shaking hands 2. Indirect contact: sneezes B. Contaminated food, water & soil C. Contaminated objects D. Infected animals Body Defenses • Barriers (First Line of Defense) – 1. Skin – 2. Breathing passages • Mucus • Cilia – 3. Mouth & stomach • Saliva • Stomach acid If something gets through the barriers: • Invaders cause damage to cells which trigger an inflammatory response (Second Line of Defense) – Fluid & white blood cells leak into tissues to fight the pathogens – Phagocyte- engulfs pathogens and digests them – Fever- higher temperature kills pathogens Immune System (3rd Line of Defense) • If pathogen is bad enough for a fever, then the 3rd line of defense is triggered, the immune response • Immune system has cells to target specific pathogens Immune System Cells • T-Cells- identify the pathogens • B-Cells- produce antibodies in response to the antigens on the pathogen to fight each different type of pathogen • Go to p. 571 sketch the diagram in your book explaining how the T cells and the B cells fight off infection. (yes, I want you to copy the exact diagram and labels) Preventing Infection • Immunity: the bodies ability to destroy pathogens before the cause the disease • Two types: – Active – Passive Active Immunity • your own body produces antibodies in response to the presence of a pathogen – When you get sick and the T & B cells fight off the pathogen, the remember it, if it comes back they are ready (chicken pox) – OR – Vaccination- when you are vaccinated some of the disease is injected into you to trigger an immune response Passive immunity • When antibodies to fight disease come from some place other than your own body – Example: babies get antibodies through breast milk & from mothers blood before birth