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QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL Click to edit Master title style A visualization tool for high level relationship and clustering analysis in networks Georgios Pavlopoulos Data integration & knowledge management group Structural and Computational Biology unit 18th September 2006 European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL visualization tools style ClickKnown to edit Master title Pajek (V. Batagelj 1998) Medusa (Sean D. Hooper 2005) Ondex (Kohler J 2006) Other programs: Osprey (Breitkreutz 2003) Cytoscape (Shannon 2003) MAPMAN (Thimm 2004) Shark (Pinney 2005) CNPlot (Batada 2004) 18th September 2006 European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL Large networks Click to editscale Master title style What if the network is a bit bigger with many connections ??????????????????????????? 18th September 2006 European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL General goal title style Click to edit Master •Flexible 3D interactive visualization tool for heterogeneous data types •Clustering Analysis •Simple and generic way for data input Example of input file •Extraction of connections Direct Connection A C Indirect Connection B A C B A 18th September 2006 C European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL Click to edit Master Outline title style Let’s see how it works 18th September 2006 European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL Snapshots-1 Click to edit Master title style 18th September 2006 European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL (Clustering) ClickSnapshots-2 to edit Master title style 18th September 2006 European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL wasMaster done last year Click What to edit title style Rewriting big part of the code 5 clustering algorithms were added Detection of indirect connetions Allowing rotations of the layers around themselves Integrated tree viewers like ATV 18th September 2006 European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL wasMaster done last year Click What to edit title style Performance improvement (faster – lower memory) Much better graphics VRML compatibility Crossovers was solved by Allowing specific rotations to each layer 18th September 2006 European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL Future Work title style Click to edit Master Biology oriented Project context AKS proceeds as a regular search engine that looks for desired query SRS is a platform for life-science database and application integration, ? providing rapid, easy and user-friendly access to the large volumes of diverse data stored in over 1000 internal and public domain databases. terms into existing scientific knowledge; it also performs a conceptual search, meaning that whether the terms found possess a relevant biological meaning, the system will retrieve all documents where that term is present in any of its conceptual definitions SRS EMBL 18th September 2006 public data European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL Future Work title style Click to edit Master 18th September 2006 European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL Click to Acknowledgements edit Master title style Reinhard Schneider (Group Leader) Venkata Satagopam (SRS administrator) Theodoros Soldatos (Text mining) Evangelos Pafilis (Web Services) Seán O'Donoghue 18th September 2006 European Molecular Biology Laboratory, Heidelberg, Germany QuickTime™ and a TIFF (U ncompressed) decompressor are needed to see this picture. EMBL Click to Acknowledgements edit Master title style 18th September 2006 European Molecular Biology Laboratory, Heidelberg, Germany