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Hajar Ashraf Gad – 12G Virtual Pathology Lab Step 1: Choose Case Step 2: Examine Smear under Microscope Hajar Ashraf Gad – 12G Step 3: Find a Similar Diagram in Hematopathology Manual Step 4: Make Diagnosis Hajar Ashraf Gad – 12G Journal Questions 1. In what ways do normal red and white blood cells differ? - Function: Red blood cells carry oxygen to the whole body, and white blood cells defend the body against viruses and infections. - Amount: There are far more RBCs than WBCs in a human body. - Structure: WBCs are larger than RBCs and are translucent because they lack hemoglobin and contain nuclei unlike RBCs (they do not have nuclei). 2. Which type of white blood cell would you expect to be most common in a normal blood smear? - I would expect to find neutrophil cells. 3. A differential count of white blood cells from a patient gave the absolute number of lymphocytes as 8000 per mm3 and the total number of white blood cells as 12,000 per mm3. Calculate the percentage of lymphocytes in this sample of white blood cells. Is this a normal or abnormal percentage? Explain your answer. - Percentage of lymphocytes = 8000/12000 100=66.67%. - The normal value of lymphocytes in the blood is 20%40%, so this would be an abnormal percentage. Hajar Ashraf Gad – 12G 4. Describe the difference between a communicable disease and an inherited disease. Use examples you have studied in this exploration to support your description. - A communicable disease is a disease that is transmitted from person to person. Ex: malaria - An inherited disease is a disease that is passed through genetics. Ex: sickle cell anemia 5. Why are white blood cells in stained blood smears usually counted at low power under a microscope? Explain your answer. - WBCs are bigger than all other blood cells, so on low power, WBCs are visible while the other cells are much less visible. 6. Why is the presence of a larger than normal number of neutrophils indicative of an infection? Explain your answer. - Neutrophil cells are responsible for destroying infectious agents in the body. The body produces neutrophils to combat infections; therefore, a large presence of neutrophils indicates that there is an infection being fought against. Hajar Ashraf Gad – 12G 7. Why would you not expect to see tissue macrophages in blood smears? Explain your answer. - Macrophages are not visible in blood smears because tissue macrophages are not in the blood (they move in tissues), and blood smears are a snapshot of what is going on in the bloodstream.