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TÜBİTAK REFERENCE MATERIALS LABORATORY CHEMISTRY GROUP REFERENCE MATERIALS LABORATORY Gebze, Kocaeli, TURKEY TÜBİTAK UME Reference Materıals Laboratory TÜBİTAK Our Aim Giving the first priority to the needs of the Turkish laboratories, we want to produce and certify reference materials in the fields of food safety, environmental and clinical analysis which will inrease the measurement quality, reliability and as a consequence increase the quality of life. Other Activities • Organizing Proficiency Tests • Supplying Training in the field of Chemical Metrology TÜBİTAK UME Chemistry Group Reference Material Production and Certification Organisation ISO CLASS 4, 5, 6 CLEAN LAB. HIGH RES. ICP MS QQQ- ICP MS Q-ICP MS AAS (GF, HG) ION CHROMATOGRAPHY LASER ABLATION MW DIGESTION PRIMARY PH MEASUREMENT (HARNED CELL) HIGH ACCURACY COULOMETER POTENTIOSTAT/GALVANOSTAT NANOVOLTMETER ELECTROLYTIC CONDUCTIVITY METER VARIABLE TRANSFORMER NMR (600 MHz) LC-MS/MS GC-MS/MS IR-MS Q-TOF LC-MS/MS MALDI-TOF MS MICRO-TOFQ LC-MS/MS TSQ GC/MS HIGH RES. TOF MS TÜBİTAK DIGITAL PCR (DPCR) REAL TIME PCR (QPCR) NANODROP SPECTROPHOTOMETER FLOW CYTOMETRY FLORECENCE MICROSCOPE TISSUE HOMOGENIZER DNA GEL ELECTROPHORESIS CENTIFUGES, INCUBATORS Trainings TÜBİTAK 8 TÜBİTAK UME researchers were trained for a year on • CRM Production, • Certification and • Primary Reference Measurement Techniques such as ID-ICP MS between years 2009-2012 in EU - JRC – IRMM, Belgium. RM Laboratory Infrastructure TÜBİTAK Analytical Instruments • • • • • • Particle Size Analyser (Laser Diffraction) Particle Size Analyser (Vibratory Sieve) Particle Size Analyser (Air Jet Sieve) Karl Fischer (Coulometric) Water Content Analyser UPLC (with DAD and FLD dedectors) System Various Balances (60 kg/d: 1g, 10 kg/d:1mg, 520 g/d:0.1mg) RM Laboratory Infrastructure TÜBİTAK Material Processing Various Crushers and Mills: Cryogenic vibrating mill, Roll mill, Variable speed rotating mill, Jaw crusher, Disc mill, Planetary ball mill, mortar mill, universal cutting mill RM Laboratory Infrastructure TÜBİTAK Material Processing Vacuum Blender Sieving Systems Various Mixers (V-Type (150 L), 3-Dimensional (2, 20 and 350 L capacity) Vibratory Feeder and Sample Divider Lyophilizers (Production Scale [3.9 m2 shelf area] and Pilot Scale [0.6 m2shelf area]) Powder Filling Machine Liquid Filling, Capping and Labelling Machine Vacuum Sachet Machine RM Laboratory Infrastructure TÜBİTAK Material Processing, Storage, Testing Water Purification System Liquid Homogenisation System 200 L Raw material storage rooms (-20, +4°C) Product storage Rooms (-20, +4 and +18 °C) Freezers (-86 and -20 °C) Storage Cabinets (+4°C) Climatic Test Chambers Reference Material Projects (Internal Funding) TÜBİTAK Completed Projects (Products on Sale) UME CRM 1301 Chloramphenicol Primary Calibrant (On sale) UME CRM 1201Elements in Spring Water (On Sale) UME CRM 1308 Vitamin D in Serum-Lyophlized (On Sale) UME CRM 1203-1&2 Sulfur in Diesel,Two Levels (On Sale) UME RM 9901 Total Contamination in Diesel (On Sale) UME RM 9902 Protein in Wheat Flour (On Sale) Ongoing Projects Aflatoxins in Dried Fig (in Certification Stage) Trace Elements in Hazelnut (in Certification Stage) Carbon Isotope Ratio Reference Materials (in Certification Stage) pH Buffer Solutions for measurement and calibration (in Certification Stage) Multiparameter in Diesel (in Certification Stage) Elements in Waste Water (in Certification Stage) http://www.ume.tubitak.gov.tr/en/laboratuvarlarimiz/reference-materials-laboratory Clinical Measurements Reference Material Project (External Funding) TÜBİTAK Ongoing Project TUBITAK ARDEP 1003 Project: Development and Production of Certified Reference Materials and Quality Control Materials for Newborn Screening and Measurements Routinely Performed by Clinical Biochemistry Labs for Amino Acids and Organic Acids (0.8 MEUR, 36 Months). Candidate CRMs & RMs: • UME CRM 1314- Target: 52 Amino Acids in human plazma, • UME CRM 1315- Target: 53 Organic acids in urine • Quality control materials (RMs) at different levels will also be produced within the scope of the project . Environmental Measurements Reference Material Project (External Funding) TÜBİTAK Recently Started Project EMPIR Call 2014 -14-RPT-03-ENVCRM Matrix Reference Materials for Environmental Analysis A consortium of 9 partners (NMI’s, DI’s, Universities) from 8 Europian countries will be coordinated by TÜBİTAK UME to produce certified reference materials [inorganics (Elements) in water &soil and organics e.g.: PFOS) in water]. Strategies for sustainable production of environmental reference materials according to the needs of end users will also be seeked (0.5 MEUR, 36 Months). 3 Candidate CRMs: Elements in Water (Waste), Elements in Soil, Organic Pollutants (PFOS, PFOA) in Water Photos From Reference Material Production TÜBİTAK Aflatoxins in Dry Fig Project Reference Material Production Chloramphenicol Primary Calibrant Reference Material Production Photos From Reference Material Production TÜBİTAK Elements in Hazelnut Project Reference Material Production Other Services (Proficiency Tests, Trainings, Tests) TÜBİTAK ENVIRONMENTAL PROFICIENCY TESTS Elements in Drinking Water (Ag, Al, As, B, Ba, Cd, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Sb, Se, Zn) Anions in Drinking Water (floride, phosfate, chloride, nitrate, nitrite and sulfate) Cations in Water (Ca, Mg, Na, K and ammonium) Suspended Solids in Water pH in Water Electrical Conductivity in Water Metals in Waste Water( As, Cd, Cr, Cu, Fe, Hg, Ni, Pb, Zn) COD in Waste Water Elements in Waste Oil ( As, Cd, Cr, Pb) Elements in Soil ( As, B, Ca, Cd, Co, Cr, Cu, Fe, Mg, Mn, Ni, Pb, Sb, Zn) pH in Soil Electrical Conductivity in Soil FUEL PROFICIENCY TESTS Gasoline Diesel Fuel-Oil Jet-A1 FOOD PROFICIENCY TESTS TRAININGS HMF, Glucose, Fructose, Sucrose in Honey (13C/12C) Isotope Ratio in Honey Refractive Index, Peroxide Value and Iodine Number in Sunflower Oil Determination of Fatty Acids Composition of Sunflower Oil Benzoate and Sorbate in Ketchup Sulfur Dioxide (SO2) in Dry Apricot Aflatoxin in food Moisture, Ash, Fat and Protein in Food Metals in Tomato Paste (Cd, Cu, Fe, Pb, Zn ve Sn) Method Validation Measurement Uncertainty in Chemical Measurements Special Trainings on Demand http://www.ume.tubitak.gov.tr/en/hizmetlerimiz/industrial-services Thank You TÜBİTAK