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III./10.1. Classification of muscle diseases In this chapter on muscle diseases, focus is on the clinically most important disorders. A detailed description of muscle diseases and rare muscle disorders are found in recommended websites and references. Muscle disorders are grouped according to the following classification, where only major subgroups are mentioned. I. Muscular dystrophies 1. Dystrophinopathies Duchenne muscural dystrophy Becker muscural dystrophy 2. Limb girdle muscural dystrophies Sarcoglycanopathies Calpainopathy Caveolinopathy Dysferlinopathy 3. Facioscapulohumeral muscural dystrophy (FSHD) 4. Myotonic dystrophy Type I (Curschmann-Steinert) Type II (PROMM) II. Inflammatory myopathies 1. Polymyositis (PM) 2. Dermatomyositis (DM) 3. Inclusion body myositis (IBM) 4. Infectious myositis III. Metabolic myopathies 1. Disorders of mitochondrial oxydative phosphorylation (OXPHOS) Mitochondrial DNA disorders Mitochondrial myopathies due to nuclear DNA mutations 2. Disorders of glycogen metabolism McArdle’s disease Pompe disease 3. Disorders of lipid metabolism Carnitine deficiency Carnitine palmityl transferase deficiency (CPTII) IV. Disorders of neuromuscular transmission 1. Myasthenia gravis 2. Eaton-Lambert syndrome V. Ion-channel disorders 1. Myotonia congenita Thomsen type Becker type VI .Endocrine, iatrogenic and toxic myopathies The following website is of help in the differential diagnosis of muscle disorders: http://neuromuscular.wustl.edu/maltbrain.html