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PowerPoint Presentation to accompany Hole’s Human Anatomy and Physiology, 9/e by Shier, Butler, and Lewis Chapter 7 Skeletal System Bone Classification • Bones are classified according to shape • Long bones are long with expanded ends, Ex: forearm and thigh bone • Short bones are cube like, Ex: wrist, ankle • Flat bones are broad and plate like, Ex: ribs, scapulae, and some skull bones • Irregular bones vary in shape, Ex: vertebrae • Sesamoid or round bones are small bones embedded in tendons, Ex: kneecap (patella) Parts of Bone • Epiphysis: end of the bone which articulates (forms a joint) with another bone. • The epiphyses are composed of spongy bone and covered with hyaline cartilage called articular cartilage. Figure 7.2 Parts of Bone • Diaphysis: shaft of the bone between the epiphyses, composed of compact bone with a medullary cavity in the center. Parts of Bone • Periosteum: fibrous tissue covering of the bone. Compact Bone • Osteocytes and layers of intercellular material lie in concentric rings around an osteonic canal. • This unit is called an osteon or Haversian system. • Osteonic canals contain blood vessels and nerve fibers and are interconnected by transverse perforating (Volkmann’s) canals. Spongy Bone • Osteocytes lie within trabeculae, branching bony plates. • Nutrients diffuse into canaliculi that lead to the trabeculae. Bone Growth and Development • The skeletal system begins to form during the first weeks of prenatal development. • Some bones originate within sheets of connective tissue (intramembranous bones). • Some bones begin as models of hyaline cartilage that are replaced by bone (endochrondral bones). Intramembranous Bones • Broad, flat skull bones are intramembranous bones. • During osteogenesis layers of primitive, connective tissue supplied with blood vessels appear at the site of future bone. Intramembranous Bones • Cells differentiate into osteoblasts (bonebuilding cells) which deposit spongy bone. • Osteoblasts become osteocytes when surrounded by bony matrix in lacunae. Intramembranous Bones • Connective tissue on the surface of the bone forms the periosteum. • Osteoblasts on the inside of the periosteum deposit compact bone over spongy bone. • This process is called intramembranous ossification. Endochondral Bones • Hyaline cartilage forms a model of the bone during embryonic development. • Cartilage degenerates, periosteum forms. • Periosteal blood vessels and osteoblasts invade the bone forming a primary ossification center in the diaphysis. • Secondary ossification centers develop in the epiphyses. Endochondral Bones • Osteoblasts form spongy bone in the space occupied by cartilage. • Osteoblasts become osteocytes when bony matrix surrounds them. Endochondral Bones • Osteoblasts beneath the periosteum deposit compact bone around spongy bone. • A band of cartilage remains between the diaphysis and epiphyses as the epiphyseal disk. Bone Growth • Growth of long bones occurs along four layers of cartilage in the epiphyseal disk. • First Layer: resting cells that do not grow. • Second Layer: young mitotic cells. • Third Layer: older cells that enlarge. • Fourth Layer: dead cells and calcified intercellular substances. Bone Homeostasis • After bone formation, osteoclasts and osteoblasts continue to remodel the bone. • Resorption and deposition are regulated to keep bone mass constant. Nutrition and Bone Development • Vitamin D is necessary to absorb calcium in the small intestine. • Vitamin D deficiency leads in rickets in children and osteomalacia in adults. Nutrition and Bone Development • Vitamin A is necessary for osteoblast and osteoclast activity. • Vitamin C is necessary for collagen synthesis. Hormones and Bone • Growth Hormone (GH) stimulates epiphyseal cartilage cell division. • Deficiency of G H: pituitary dwarfism. Excess GH: pituitary gigantism in children and acromegaly in adults. Hormones and Bone • Thyroid hormone stimulates cartilage replacement in the epiphyseal disks. • Sex steroids promote formation of bone tissue close the epiphyseal disk. Physical Factors Affecting Bone • Physical stress stimulates bone growth. • Weight bearing exercise stimulates bone tissue to thicken and strengthen (hypertrophy). • Lack of exercise leads to bone wasting (atrophy). Bone Function • Bones shape, support, and protect body structures. • Bones act as levers to create body movement with muscles. • Bones house blood cell producing tissue. • Bones store inorganic salts. Support and Protection • Bones give shape to the head, face, chest, and limbs. • Bones of the skull protect structures like the eyes, ears, and brain. • Bones of the rib cage and shoulder protect the heart and lungs. • Bones of the pelvic girdle protect the abdominal and reproductive organs. Body Movement • When body parts move, bones and muscle act as levers. Body Movement • A lever has four parts: a bar, a fulcrum, an object moved, a force to supply energy. • There are three classes of levers. Figure 7.13 Body Movement Body Movement Body Movement Figure 7.14 Body Movement Fracture Repair • Blood escapes from damaged blood vessels and forms a hematoma. • Spongy bone forms in regions near blood vessels and fibrocartilage forms farther away. • A bony callus replaces the fibrocartilage. • Osteoclasts remove excess bony tissue, restoring new bone much like the original. Blood Cell Formation • Blood cell formation (hematologists) occurs in yolk sac in early development. • Later it occurs in the liver and spleen. • In the adult red and white blood cells are formed in the red bone marrow. Blood Cell Formation • Red marrow fills the cavity in the diaphesis of the long bones in infants. In adults it is replaced with yellow marrow (fat). • Adult red marrow is found in spongy bone of the skull, ribs, sternum, vertebrae, pelvis. Inorganic Salt Storage • Salts account for 70% of the bone matrix. • These salts are mostly calcium phosphate crystals called hydroxyapatite. Inorganic Salt Storage • Parathyroid hormone stimulates osteoclasts to break down bone when Ca levels are low. • Calcitonin stimulates osteoblasts to build bone when Ca levels are high. • Bone contains Mg, Na, K, and carbonate ions. Axial Skeleton • The skeleton has two divisions: the axial and the appendicular skeleton. • The axial skeleton consists bones that support organs of the head, neck, and trunk. • Skull :cranium and facial bones. • Hyoid bone. • Vertebral column. • Thoracic cage: ribs and sternum. Appendicular Skeleton • The appendicular skeleton consists of the bones of the limbs and bones that anchor the limbs to the axial skeleton. • Pectoral girdle: scapula, clavicle. • Upper limbs: humerus, radium, ulna, carpals, metacarpals, phalanges. • Pelvic girdle: coxal bones. • Lower limbs: femur, tibia, fibula, patella, tarsals, metatarsals, phalanges. Figure 7.17 Figure 7.17 Cranium • • • • • • Frontal bone: forehead Parietal bones: top of the skull Occipital bone: back of the skull Temporal bones: side of skull, near ears Sphenoid bone:base of the cranium Ethmoid bone: roof of the nasal cavity Figure 7.19 Figure 7.19 Figure 7.21 Figure 7.21 Figure 7.22 Figure 7.22 Facial Skeleton • • • • • • • • Maxillary bones: upper jaw, hard palate Palatine bones: hard palate, nasal cavity Zygomatic bones: cheek bones Lacrimal bones: orbit of the eye Nasal bones: bridge of the nose Vomer bone: nasal septum Nasal conchae:walls of the nasal cavity Mandible: lower jaw Figure 7.29 Figure 7.29 Figure 7.29 Infantile Skull • The skull at birth is not fully developed. • Fibrous membranes, fontanels, connect the cranial bones. • The fontanels allow movement of the bones to enable the skull to pass through the birth canal. • The fontanels close as cranial bones grow. Figure 7.33 Figure 7.33 Vertebral Column • Cervical vertebrae: seven vertebrae of the neck, includes atlas and axis • Thoracic vertebrae: twelve vertebrae that articulate with the ribs • Lumbar vertebrae: five vertebrae that make up the small of the back Vertebral Column • Sacrum: five vertebrae that fuse in early adulthood, part of the pelvis • Coccyx: four small fused vertebrae Figure 7.34 Thoracic Cage • Ribs: twelve pair of ribs attached to each thoracic vertebrae. • Seven pairs: true ribs and attach to the sternum by costal cartilage. • Two pairs: false ribs that attach to cartilage. Thoracic Cage • Two pairs: floating ribs that do not attach to the sternum or its cartilage. • Sternum: the manubrium, the body, and the xyphoid process. Pectoral Girdle • Clavicles: collar bones that attach the sternum to the shoulder anteriorly. • Scapulae: shoulder blades with two processes. • Acromion process: tip of the shoulder. • Coracoid process: attaches to the clavicle and provides attachments for muscles. • Glenoid fossa articulates with the humerus. Figure 7.42 Upper limb • Humerus: upper arm bone, articulates with the glenoid fossa of the scapula Upper limb • Radius: thumb side of the forearm, articulates with the capitulum of the humerus and the radial notch of the ulna • Ulna: longer bone of the forearm, olecranon and coronoid processes articulate with the humerus Hand • Carpal bones: eight small bones of the wrist. • Metacarpal bones: five bones, the framework of the palm. • Phalanges: finger bones, three in each finger (proximal, middle, distal phalanx), two in the thumb. Figure 7.47 Pelvic Girdle • Coxal bones: two hips bones composed of three fused bones. • Ilium: superior part of the coxal bone. • Ischium: lowest portion of the coxal bone. • Pubis: anterior part of the coxal bone. The two pubic bones joint at the symphysis pubis. Figure 7.49 Figure 7.49 Male and Female Pelvis • Female iliac bones are more flared. • The female pubic arch angle is greater. • There is a greater distance between the ischial spines and tuberosities in the female. • The sacral curvature is shorter and flatter. • The differences create a wider pelvic cavity. Figure 7.51 Lower Limb • Femur: thigh bone, longest bone • Patella: kneecap, located in a tendon, femur, tibia, and patella form the knee joint • Tibia: shinbone, lateral malleolus forms the ankle • Fibula: slender bone lateral to the tibia, not part of the knee joint Figure 7.52 Foot • Tarsal bones: seven small bones in the ankle. The calcaneus (heel bone) is the largest, located below the talus. • Metatarsal bones: elongated bones that form the arch of the foot. • Phalanges: each toe has three except the great tow which has two. Figure 7.55 Life-Span Changes • Calcium levels fall through life and the skeleton loses strength. • Osteoclasts outnumber osteoblasts. Life-Span Changes • By age 35, everyone loses bone mass. Women lose bone mass faster between menopause and age seventy. • Trabecular bone is lost before compact bone.