Download coenzyme Q-10 (ko-en-zime-cue-ten)

Name /bks_53161_deglins_md_disk/coenzymeq10
02/19/2014 01:31PM
Plate # 0-Composite
pg 1 # 1
Interactions
Natural Product-Drug: HMG CoA reductase inhibitors (statins) canpco-
1
coenzyme Q-10 (ko-en-zime-cue-ten)
enzyme Q-10 levels. Mayqrisk of clotting with anticoagulants. May have additive
hypotensive effects with antihypertensives. May protect against anthracycline-associated cardiotoxicity.
Natural-Natural Products: Red yeast canpcoenzyme Q-10 levels. May have
additive hypotensive effects with herbs that can lower BP including fish oil and L-arginine.
Other Name(s):
coQ10, ubiquinol, ubiquinone
Classification
Therapeutic: antioxidants
Route/Commonly Used Doses
Common Uses
Heart failure. Coenzyme Q– 10 deficiency. Mitochondrial disorders. Muscular dystrophy. Immune stimulant in HIV infection. Parkinson’s disease.
Action
A co-factor in oxidative respiration for the Krebs cycle and the electron transport
chain important for mitochondrial ATP generation. It also has antioxidant activity and
membrane stabilizing ability. Therapeutic Effects: Antioxidant effects.
Pharmacokinetics
Absorption: Poor absorption in the GI tract, absorbed primarily in the small intestine.
Distribution: Unknown.
Metabolism and Excretion: Metabolized in all tissues, elimination via biliary
PO (Adults): Coenzyme Q-10 deficiency— 150 mg daily; Mitochondrial disorders— 150– 160 mg daily or 2 mg/kg/day; Heart failure— 60– 100 mg daily; HIV/
AIDS— 200 mg daily; Parkinson’s disease— 300– 2400 mg daily; Muscular dystrophy— 100 mg daily.
NURSING IMPLICATIONS
Assessment
● Monitor BP periodically during therapy.
● Lab Test Considerations: Monitor coagulation studies periodically during
therapy.
● Monitor blood glucose during therapy; may cause hypoglycemia.
● Monitor lipid levels and serum lactate periodically during therapy.
and fecal excretion.
Potential Nursing Diagnoses
Half-life: 34 hrs.
Activity intolerance
TIME/ACTION PROFILE
PO
ONSET
PEAK
DURATION
Unknown
5–10 hrs
Unknown
Contraindications/Precautions
Contraindicated in: OB: Pregnancy and lactation; Allergy/hypersensitivity.
Use Cautiously in: Hypotension; Surgery (discontinue 2 weeks prior to procedure).
Adverse Reactions/Side Effects
CNS: dizziness. CV: hypotension. Derm: rash. GI: nausea, vomiting, diarrhea,
heartburn, decreased appetite.
⫽ Canadian drug name.
⫽ Genetic Implication.
Implementation
● PO: Administer with a meal containing fat for optimal absorption.
Patient/Family Teaching
● Instruct patient to take with a meal containing fat, as directed.
● May cause dizziness. Caution patient to avoid driving or other activities requiring
alertness until response to medication is known.
Evaluation
● Antioxidant effects in a variety of conditions.
Why was this drug prescribed for your patient?
CAPITALS indicate life-threatening, underlines indicate most frequent.
Strikethrough ⫽ Discontinued.
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