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Name /bks_53161_deglins_md_disk/coenzymeq10 02/19/2014 01:31PM Plate # 0-Composite pg 1 # 1 Interactions Natural Product-Drug: HMG CoA reductase inhibitors (statins) canpco- 1 coenzyme Q-10 (ko-en-zime-cue-ten) enzyme Q-10 levels. Mayqrisk of clotting with anticoagulants. May have additive hypotensive effects with antihypertensives. May protect against anthracycline-associated cardiotoxicity. Natural-Natural Products: Red yeast canpcoenzyme Q-10 levels. May have additive hypotensive effects with herbs that can lower BP including fish oil and L-arginine. Other Name(s): coQ10, ubiquinol, ubiquinone Classification Therapeutic: antioxidants Route/Commonly Used Doses Common Uses Heart failure. Coenzyme Q– 10 deficiency. Mitochondrial disorders. Muscular dystrophy. Immune stimulant in HIV infection. Parkinson’s disease. Action A co-factor in oxidative respiration for the Krebs cycle and the electron transport chain important for mitochondrial ATP generation. It also has antioxidant activity and membrane stabilizing ability. Therapeutic Effects: Antioxidant effects. Pharmacokinetics Absorption: Poor absorption in the GI tract, absorbed primarily in the small intestine. Distribution: Unknown. Metabolism and Excretion: Metabolized in all tissues, elimination via biliary PO (Adults): Coenzyme Q-10 deficiency— 150 mg daily; Mitochondrial disorders— 150– 160 mg daily or 2 mg/kg/day; Heart failure— 60– 100 mg daily; HIV/ AIDS— 200 mg daily; Parkinson’s disease— 300– 2400 mg daily; Muscular dystrophy— 100 mg daily. NURSING IMPLICATIONS Assessment ● Monitor BP periodically during therapy. ● Lab Test Considerations: Monitor coagulation studies periodically during therapy. ● Monitor blood glucose during therapy; may cause hypoglycemia. ● Monitor lipid levels and serum lactate periodically during therapy. and fecal excretion. Potential Nursing Diagnoses Half-life: 34 hrs. Activity intolerance TIME/ACTION PROFILE PO ONSET PEAK DURATION Unknown 5–10 hrs Unknown Contraindications/Precautions Contraindicated in: OB: Pregnancy and lactation; Allergy/hypersensitivity. Use Cautiously in: Hypotension; Surgery (discontinue 2 weeks prior to procedure). Adverse Reactions/Side Effects CNS: dizziness. CV: hypotension. Derm: rash. GI: nausea, vomiting, diarrhea, heartburn, decreased appetite. ⫽ Canadian drug name. ⫽ Genetic Implication. Implementation ● PO: Administer with a meal containing fat for optimal absorption. Patient/Family Teaching ● Instruct patient to take with a meal containing fat, as directed. ● May cause dizziness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known. Evaluation ● Antioxidant effects in a variety of conditions. Why was this drug prescribed for your patient? CAPITALS indicate life-threatening, underlines indicate most frequent. Strikethrough ⫽ Discontinued. PDF Page #1