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Cleavage, Blastulation and Gastrulation Cleavage • How does the cell cycle of blastomeres compare with that of somatic cells? Cleavage • What is karyokinesis and cytokinesis and how do they compare? Cleavage Cleavage • Cytoplasmic determinant is a molecule found in the egg that helps direct early development • Affect development independently of sperm or zygote genotype • Involved in differentiation—the generation of different cell types from a single cell Gastrulation