Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Computational electromagnetics wikipedia , lookup
Computational fluid dynamics wikipedia , lookup
Operations research wikipedia , lookup
Mathematical economics wikipedia , lookup
Mathematical physics wikipedia , lookup
Evolving digital ecological networks wikipedia , lookup
Plateau principle wikipedia , lookup
Agent-based model wikipedia , lookup
NIMBioS Investigative Workshop • May 13-15, 2010 • Goal: to explore mathematical problems and modeling and analysis tools in describing the life cycle, stage conversion, and clonal expansion of Toxoplasma gondii • 45 participants • Organizers: Su, Lenhart, Langlais, Dubey, Joo, Zhao Selected Highlights • • • • • Very productive (88%) Met expectations (91%) Presentations useful (100%) Group discussions useful (88%) Improved understanding of ongoing research in other disciplines regarding T. gondii (100%) NIMBioS Evaluation Report, Pamela Bishop Participant Demographics • Brazil, China, Colombia, France, Mexico, Nigeria, and US (16 states) • Demographics – business/industry employees (3%), – college/university faculty or staff (45%), – graduate students (23%), – government employees (7%), – non-profit employees (2%) – postdoctoral researchers (13%) Summary and Recommendation • Robust transmission mechanisms due to its complex epidemic network • Stabilities and epidemic characteristics of different life cycles; evolutionary advantages of complex life cycles versus simple life cycles. • Host-pathogen interactions of in vitro and in vivo T. gondii infection; different strain types; delicate balance between T. gondii invasion dynamics and host immune response. • Multiscale models; integrating within-host dynamics with transmission dynamics • Working group on dynamic modeling of toxoplasmosis NIMBioS Working Group Integrated Modeling and Analysis of within-host Infection and between-host Transmission for Toxoplasma gondii Multiscale Modeling of the Life Cycle of Toxoplasma gondii 3/4 meetings in 2011—2013 Organizers: Feng, Mordue, Su, Zhao Objectives 1. develop a mathematical framework to understand within-host infection dynamics 2. explore new mathematical models to investigate the characteristics of the complex transmission pathways of T. gondii 3. integrate within-host and between-host models to understand the influences of various properties of the parasites on their genetic diversities and bio-geographic patterns 4. other important problems identified by the working group Suggested Topics • Population dynamics (using different approaches, ode, agent based modeling, stochastic modeling) • Multi-patch interactions • Evolutionary dynamics • Linking between and within host dynamics • Stage conversion and cell cycle • Immune response • Multiscale modeling and analysis • Control (vaccine, human factors, drug, natural interaction) Agenda • Flexible agenda • Suggested schedule • Other relevant presentations